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Calvin Ridley WR | TEN
Titans' Calvin Ridley: Two snags in loss
Ridley caught two of three targets for 33 yards during Sunday's 26-3 loss to the Texans.
Ridley was limited to two or fewer catches for the fifth straight game to open the regular season, and he has yet to exceed 35 receiving yards in a contest this year. The wide receiver has reeled in five of eight targets for 81 yards over five contests this season, and he'll continue to have a rather low floor from a fantasy perspective in Week 6 against the Colts.
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Rashid Shaheed WR | SEA
Seahawks' Rashid Shaheed: Two catches in defeat
Shaheed caught two of four targets for 23 yards while also adding 86 kickoff-return yards during Sunday's 32-29 loss to the 49ers.
Shaheed was held to two or fewer catches for the fourth time in five games, and he has yet to score a touchdown through the air through the air this year. The wide receiver played a season-low 28 offensive snaps in Week 5, and his upside is rather low as a fantasy asset at the moment. On the year, Shaheed has caught nine of 19 targets for 96 yards while adding three carries for 37 yards and a touchdown and 359 yards as a kick returner.
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Jauan Jennings WR | MIN
Vikings' Jauan Jennings: Doesn't catch only target Sunday
Jennings did not reel in his only target during Sunday's 23-13 win at New Orleans.
Jennings again got the second most snaps at wide receiver for the Vikings (47) in Week 5 with Jordan Addison (hamstring) out, but it only translated to one target on the afternoon. Jennings has failed to draw more than two targets in any game so far this season, and his role could be further diminished after Minnesota's bye in Week 6 if Addison is able to return to action.
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Tom Kennedy WR | DET
Lions' Tom Kennedy: Season-ending surgery confirmed
Head coach Dan Campbell confirmed Monday that Kennedy will undergo season-ending surgery to repair an MCL injury in his right knee, Nolan Bianchi of The Detroit News reports.
Kennedy sustained the knee injury while returning a punt during the second quarter of Sunday's 45-21 win over the Cardinals. The veteran wide receiver is an unrestricted free agent this offseason, but he'll nonetheless shift his focus toward being fully healthy for the 2027 season. Jacob Saylors will take over return duties on kickoffs and may also work as a returner on punts given the Lions' hesitation to use Amon-Ra St. Brown as the full-time returner on punts, per Bianchi.
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Irvin Charles WR | SEA
Seahawks' Irvin Charles: Full participant on Monday's estimate
Charles (knee) was estimated as a full practice participant on Monday's injury report, John Boyle of the Seahawks' official site reports.
Charles' 21-day practice window opened this past Wednesday, but he was not activated from injured reserve before the Seahawks' 32-29 loss to the 49ers on Sunday. He could be removed from IR ahead of Thursday's game against the Broncos, but Charles would have to log a full session during a normal practice to have a realistic chance of playing against Denver.
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Tre Harris WR | LAC
Chargers' Tre' Harris: Considered week-to-week
Head coach Jim Harbaugh said Monday that Harris is "week-to-week" due to a hamstring injury that he sustained during Sunday's 23-17 loss to the Broncos, Alex Insdorf of BoltBeat.com reports.
Harris entered Sunday as the Chargers' WR1 due to the absence of Quentin Johnston (chest) while Ladd McConkey (foot) was available only as an emergency option, per Insdorf. Harris caught two of four passes for 16 yards before sustaining a hamstring injury, which was severe enough for him to not return. Given Harbaugh's update, coupled with the Chargers' bye scheduled for Week 7, it seems likely that Harris will be held out for Week 6 against the Chiefs, with an eye toward being available for Week 8 against the Rams on Sunday, Nov. 1. Given the Chargers' injuries to the wide receiver position, the team will need to lean more heavily on Marquez Valdes-Scantling, Theo Wease, Derius Davis and tight ends Charlie Kolar and Oronde Gadsden in the passing game.
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David Sills WR | TB
Buccaneers' David Sills: Practice window opened
Sills (hamstring) had his 21-day practice window opened by the Buccaneers on Monday, Scott Smith & Brianna Dix of the team's official website reports.
Sills has been on injured reserve since late August while nursing a hamstring injury, but he will now have the chance to return to practice. The wide receiver played in all 17 of the Falcons' regular-season contests in 2025, and once healthy, he'll provide Tampa Bay with another veteran option on offense.
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DJ Moore WR | BUF
Bills' DJ Moore: Inactive in Week 5
Moore (shoulder) is listed as inactive Monday at the Rams.
After suffering a shoulder injury in Week 4, Moore wasn't expected to be tending to a long-term issue, and head coach Joe Brady told Katherine Fitzgerald of The Buffalo News on Thursday that the wide receiver was "going to be able to do everything he can to be able to rock this week." Moore then managed just one limited session (Saturday) during Week 5 prep, which wasn't enough for him to gain clearance to play Monday. With both Moore and Joshua Palmer (shoulder) unavailable, Khalil Shakir, Keon Coleman, Greg Dortch, Skyler Bell and Trent Sherfield will handle WR reps for the Bills.
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Ben Skowronek WR | PIT
Steelers' Ben Skowronek: Already ruled out for Week 6
Head coach Mike McCarthy said Monday that Skowronek (calf) will not play against the Buccaneers this Sunday, Alan Saunders of SteelersNow.com reports.
Skowronek was diagnosed with a leg injury during the Steelers' 34-22 win over the Colts, which he picked up after a punt return in the first half. He was unable to return to the contest, and his calf issue will cost him at least one game, with his next chance to play being Week 7 against the Saints in Paris on Sunday, Oct. 25. Roman Wilson (finger) has also been ruled out for Week 6, so rookie second-rounder Germie Bernard, Kaden Wetjen and Brandon Smith are all in line for additional snaps on offense against Tampa Bay.
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Christian Kirk WR | SF
49ers' Christian Kirk: Unlikely to practice during Week 6 prep
Head coach Kyle Shanahan said Monday that Kirk (calf) is "unlikely" to return to practice this week, Nick Wagoner of ESPN.com reports.
The 49ers' wide receiver room is even more thin following the team's 32-29 win over the Seahawks on Sunday, when Deebo Samuel left the game due to a hamstring injury. Kirk opened the regular season on IR because of a calf injury that he sustained in late July, and while he has progressed in his recovery, he's not quite ready to return to practice. With both Samuel and Kirk sidelined, the 49ers will turn to one of Brandin Cooks, Jordan Watkins and Jacob Cowing to operate as the WR2 behind Mike Evans.