McCaffrey is slated to serve as the Commanders' top wide receiver for Sunday's NFC East tilt against the Cowboys due to the absences of Terry McLaurin (quadriceps), Noah Brown (groin/knee) and Deebo Samuel (heel), Mike Garafolo of NFL Network reports.

McLaurin will miss a fourth straight game while working through a quadriceps injury, Brown was placed on injured reserve Wednesday and Samuel was officially ruled out Saturday due to a lingering heel issue. That leaves the Commanders with three healthy wide receivers on the active roster in McCaffrey, rookie fourth-rounder Jaylin Lane and veteran Chris Moore, while Robbie Chosen, Ja'Corey Brooks, Jacoby Jones and Treylon Burks are options to be elevated from the practice squad for Sunday's contest. McCaffrey hasn't seen more than three targets in each of the first six games of the regular season. However, he has caught three touchdown passes over his last four games, and the 2024 third-rounder should see more targets from Jayden Daniels against a Dallas secondary that will be without starting cornerback Trevon Diggs (concussion) and could be without starting safety Juanyeh Thomas (migraine).

Samuel (heel) has been ruled out for Sunday's game against the Cowboys.

Samuel was able to draw the questionable tag for Week 7 after logging a limited practice Friday, but the seventh-year wideout will not travel with the team to Dallas due to a lingering heel injury. The Commanders will be without Samuel, Terry McLaurin (quadriceps) and Noah Brown (groin) for Sunday's NFC East tilt, which leaves Luke McCaffrey, rookie fourth-rounder Jaylin Lane and Chris Moore as the top wideouts in the passing game for Jayden Daniels. Tight end Zach Ertz would also be in line for more work on offense in the absence of Samuel, but the former is listed as questionable for Week 7 due to foot and shoulder injuries. Samuel's next opportunity to play is Week 8 against the Chiefs on Monday, Oct. 27.

The Panthers activated Coker (quadriceps) from injured reserve Saturday, but he remains questionable for Sunday's game at the Jets, Darin Gantt of the team's official site reports.

Coker has been a full practice participant over the past two weeks, and his return from IR indicates that he's tracking toward playing Week 7. The second-year wideout finished his rookie campaign with 32 catches (on 46 targets) for 478 yards and two touchdowns across 11 regular-season games. Coker should be utilized in two- and three-wideout sets alongside rookie first-rounder Tetairoa McMillan, which would result in a decrease in offensive snaps for Xavier Legette and Hunter Renfrow.

Mingo (knee) has been ruled out for Sunday's game against the Commanders and will remain on injured reserve.

Mingo earned the questionable tag for Week 7 after logging a full practice Friday, but the third-year wideout hasn't progressed enough in his recovery to return from a PCL sprain in his right knee that he sustained during the preseason in mid-August. Mingo's 21-day window to be activated from injured reserve opened Oct. 1, and he would be forced to remain on IR for the rest of the season if the Cowboys don't activate him prior to the window closing. Mingo's next opportunity to make his 2025 regular-season debut is Week 8 against the Broncos on Sunday, Oct. 26.

Godwin (fibula) has been ruled out for Monday's game against the Lions, Adam Schefter of ESPN reports.

Godwin will be sidelined for a second consecutive game due to a fibula injury that he picked up during the Buccaneers' Week 5 win over the Seahawks. The injury isn't related to the fibula that he broke during the 2024 campaign, but the Bucs will continue to play things cautiously with the veteran wideout. With Tampa Bay on a bye in Week 9, the Buccaneers could hold Godwin out for Week 8 against the Saints to give the veteran wideout more time to heal, per Greg Auman of Fox Sports. With Godwin and Bucky Irving (foot/shoulder) both ruled out, Baker Mayfield and the Buccaneers may have to rely more heavily on Rachaad White, Sterling Shepard, Tez Johnson and Cade Otton in the offense depending on the statuses of Mike Evans (hamstring) and Emeka Egbuka (hamstring), both of whom are considered game-time calls for Monday night's game in Detroit.

Evans (hamstring) was a participant in Saturday's practice and is considered a game-time decision for Monday's game against Detroit, Adam Schefter of ESPN reports.

The veteran wide receiver was on the field for Saturday's practice after taking a rest day Friday. Evans has not yet been given the green light to make his return from a three-game absence, and he joins rookie Emeka Egbuka (hamstring) as game-time calls for Monday night against the Lions. Chris Godwin (fibula) has already been ruled out, and with the Bucs playing in the penultimate game of Week 7, fantasy managers won't have as many options at wide receiver to fall back on if one or both of Evans and Egbuka was to ultimately be ruled out. Sterling Shepard, seventh-round rookie Tez Johnson, Ryan Miller, Kameron Johnson and tight end Cade Otton would be in line to see more targets from Baker Mayfield if Evans or Egubka (or both) were to be sidelined.

Egbuka (hamstring) was a limited participant in Saturday's practice and is considered a game-time decision for Monday's game against the Lions, Adam Schefter of ESPN reports.

The rookie wideout suffered a hamstring injury against the 49ers in Week 6, which caused him to miss the first two practices of the week. However, Egubka managed to practice in a limited capacity Saturday, which gives him a chance at playing Monday night in Detroit. With two games taking place Monday, fantasy managers won't have as many options to work with if Egbuka ends up not playing. Chris Godwin (fibula) has been ruled out and Egbuka and Mike Evans (hamstring) are both game-time calls, which leaves Sterling Shepard, Tez Johnson, Ryan Miller and Kameron Johnson as the Tampa Bay wideouts without an injury designation heading into Week 7. Tight end Cade Otton would also be in line for an uptick in targets from Baker Mayfield if one or both of Egbuka and Evans were ruled out.

Kirk (hamstring) will not participate in Saturday's practice, Aaron Wilson of KPRC 2 Houston reports.

Kirk popped up on Friday's practice report as a limited participant due to a hamstring injury. His downgrade to a DNP doesn't bode well for his chances of playing against the Seahawks on Monday, and his injury designation should be announced by the Texans following the conclusion of Saturday's practice. The Texans would turn to Xavier Hutchinson and rookies Jayden Higgins and Jaylin Noel to take on larger roles in the offense behind top wideout Nico Collins if Kirk is not cleared to play against Seattle.

Slayton (hamstring) has been ruled out for Sunday's game against the Broncos, Dan Salomone of the Giants' official site reports.

Slayton has not practiced since injuring his hamstring during the Giants' Week 5 loss to the Saints. The seventh-year wideout will be sidelined for a second straight game due to his injury, and he'll work to progress enough in his recovery to return in Week 8 against the Eagles on Sunday, Oct. 26. Lil'Jordan Humphrey should be elevated from the practice squad to the active roster for a second-straight week to join the Giants' wide receiver corps that consists of Wan'Dale Robinson, Jalin Hyatt, Beaux Collins and Gunner Olszewski.

Egbuka (hamstring) returned to practice Saturday, Rick Stroud of the Tampa Bay Times reports.

Egbuka missed the Buccaneers' first two practices of the week due to a hamstring injury he picked up in Week 6 against the 49ers. Although the rookie wideout is considered a longshot to play against the Lions on Monday, his ability to return to practice Saturday is a sign that he is progressing in his recovery. The Buccaneers will announce their injury designations following Saturday's practice, which will shed light on Egbuka's chances of suiting up against Detroit.