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Caleb Williams QB | CHI
Bears' Caleb Williams: Produces four TDs in huge Week 1 win
Williams completed 21 of 29 passes for 269 yards and two touchdowns while carrying the ball 10 times for 65 yards and two more TDs in Sunday's 59-37 win over the Panthers.
In the highest-scoring Week 1 game in NFL history, Williams led the Bears on nine separate scoring drives, tossing touchdowns to Cole Kmet in the second quarter and Jahdae Walker in the fourth while adding rushing scores of his own in the first and second quarters. The third-year QB produced a career-high 30 touchdowns in 2025, 27 through the air and three on the ground, but he may be poised to shatter that mark in 2026. Williams will face a likely tougher test at home in Week 2 against the Vikings.
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Lamar Jackson QB | BAL
Ravens' Lamar Jackson: Stellar numbers in Week 1 win
Jackson completed 17 of 25 passes for 324 yards with one touchdown and no interceptions while adding seven rushes for 40 yards and another score in Sunday's 41-23 win over the Colts. He also lost a fumble.
Although Derrick Henry put together a dominant performance of 144 rushing yards and three touchdowns, Jackson still found his way to a standout afternoon that included an average of 13.0 yards per attempt. Jackson also was the first to strike for Baltimore, capping off the Ravens' first possession with a five-yard scoring run. He went on to add a 54-yard scoring strike to Zay Flowers (hamstring) in the first half, and the one blemish on the star quarterback's afternoon was his fumble on a sack deep in his own territory during the latter portion of the second quarter. Jackson ultimately connected with nine different targets overall, and his impressive passing yardage figure was generated with Flowers missing the entire second half because of his injury. Jackson's prospects will remain bright in a Week 2 home matchup next Sunday against a Saints team that allowed 31 points to the Lions in Week 1.
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Dalton Kincaid TE | BUF
Bills' Dalton Kincaid: Career-high 130 yards in Week 1
Kincaid caught five of six targets for 130 yards in Sunday's 36-31 win over the Texans.
Kincaid did most of his damage late, recording catches of 40 and 35 yards in the fourth quarter. He cleared offseason addition DJ Moore by 30 receiving yards for the team lead while tying Khalil Shakir for second in targets behind Moore's eight. Kincaid played through a knee injury last season but looked healthy in this season opener while setting a new single-game career high in receiving yards. He'll try to keep rolling in Thursday's Week 2 home game against the Lions.
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DJ Moore WR | BUF
Bills' DJ Moore: Posts 100 yards, TD in Bills debut
Moore caught five of eight targets for 100 yards and a touchdown in Sunday's 36-31 win over the Texans.
Moore made a strong first impression with the Bills, highlighted by a 43-yard touchdown catch in the second quarter. The 29-year-old wide receiver had a career-low 682 receiving yards in 17 regular-season games with the Bears last year, but he has exceeded 1,000 yards in four of eight regular seasons split between the Panthers and Bears. Josh Allen spread the ball around as usual against Houston, but Moore paced the team with eight targets. Moore will look to build on this productive debut in Thursday's home opener against the Lions.
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Kyler Murray QB | MIN
Vikings' Kyler Murray: Won't return to Sunday's game
Murray (concussion) has been ruled out of Sunday's contest against the Packers, Alec Lewis of The Athletic reports.
Murray was sandwiched by a pair of Green Bay defenders while going to the ground in the first quarter, drawing an unnecessary roughness penalty in the process. He immediately was under evaluation for a head injury before the Vikings deemed him unable to return. Carson Wentz took over under center for Murray, while J.J. McCarthy's status as the emergency third quarterback means he could make an appearance if Wentz also leaves with an injury.
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Dylan Sampson RB | CLE
Browns' Dylan Sampson: On crutches after hurting knee
Sampson was on crutches and wearing a brace on the left knee he injured during Sunday's loss to Jacksonville, Mary Kay Cabot of The Cleveland Plain Dealer reports.
Sampson was hurt in the first quarter. He was initially deemed questionable but was eventually downgraded to out after being evaluated in the medical tent and the locker room. Quinshon Judkins (12 carries) and Raheim Sanders (one carry) were the only Browns running backs to log any totes during the Week 1 defeat. Sampson is slated to undergo further testing Monday, per Daniel Oyefusi of ESPN.com.
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Derrick Henry RB | BAL
Ravens' Derrick Henry: Dominant in Week 1 win
Henry rushed 24 times for 144 yards and three touchdowns and brought in his only target for 19 yards in the Ravens' 41-23 win over the Colts on Sunday.
Much like he'd done at the expense of the Bills in Week 1 of last season, Henry turned in one of his signature performances right out of the gate, and he struck for his first two touchdowns in the first half from four and 32 yards away. The superstar running back added a three-yard scoring run early in the fourth quarter, and he consistently ripped off chunk gains throughout the afternoon at the expense of an overwhelmed Colts front. Henry's workload won't change under new head coach Jesse Minter if Sunday is any indication, and the perennial Pro Bowl back carries a stellar outlook for a Week 2 home matchup against a Saints defense that the Lions' Jahmyr Gibbs gashed for 156 rushing yards and two touchdowns Sunday.
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Henry To'oTo'o LB | HOU
Texans' Henry To'oTo'o: Suffers shoulder injury in loss
To'oTo'o (shoulder) was seen in a sling after Sunday's 36-31 loss to the Bills, Aaron Wilson of KPRC 2 Houston reports.
To'oTo'o suffered a shoulder injury in the fourth quarter of Sunday's loss. The linebacker was seen after the contest in a sling but it is unclear how severe the issue truly is.
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Jonathan Taylor RB | IND
Colts' Jonathan Taylor: Strong numbers in lopsided loss
Taylor rushed 19 times for 98 yards and two touchdowns and brought in three of four targets for 23 yards in the Colts' 41-23 loss to the Ravens on Sunday. He also lost a fumble.
Taylor and the Colts' offense as a whole got the new season off to a highly encouraging start, capping off a crisp opening drive with the star running back's one-yard touchdown run. Taylor would go on to add a three-yard scoring rush late in the first half after the Ravens had gone on to rattle off 28 straight points, with Taylor's fumble after a 14-yard reception leading to one of Baltimore's touchdowns. Outside of the turnover, Taylor's overall numbers in a game during which his rushing opportunities were capped late were still useful for fantasy managers, and he'll be slated for another prominent role in a Week 2 road showdown against the Chiefs next Sunday night.
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James Cook III RB | BUF
Bills' James Cook: Held in check by Houston
Cook rushed 13 times for 57 yards and caught three of four targets for 12 yards in Sunday's 36-31 win over the Texans.
Cook didn't find much room against Houston's stout front and took a back seat to Josh Allen, who had two rushing touchdowns and two touchdown passes. Allen's presence didn't stop Cook from rushing for a league-high 1,621 rushing yards during the 2025 regular season, so there should be better days ahead for Buffalo's shifty running back. Cook will have a short turnaround before Buffalo's home opener against the Lions on Thursday.