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Brandon Aiyuk WR | SF
49ers' Brandon Aiyuk: Unlikely to practice this week
Head coach Kyle Shanahan said Monday that the 49ers don't intend to open Aiyuk's (knee) practice window this week, Nick Wagoner of ESPN.com reports.
Aiyuk remains in the rehab stages of the torn ACL and MCL that he suffered in his right knee Week 7 of last season. Shanahan told David Lombardi of SFStandard.com last Wednesday that he's "pretty confident" Aiyuk will play at some point this season, but it's unlikely to happen this coming Sunday and probably for at least a few more weeks after that point.
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Ricky Pearsall WR | SF
49ers' Ricky Pearsall: May practice Wednesday
Coach Kyle Shanahan said Monday that Pearsall (knee) has a chance to practice Wednesday, Matt Barrows of The Athletic reports.
Pearsall hasn't practiced since initially suffering a PCL injury in his right knee Week 4, but he has worked out on the side on multiple occasions in recent weeks. Shanahan told Nick Wagoner of ESPN.com that "hopefully the next two days go good, and if they do, he'll be back out there. ... He had a good weekend." Wednesday's injury report not only will reveal if Pearsall was able to mix back into drills, but if No. 1 QB Brock Purdy (toe) has put himself in a position for his own first game action since Week 4.
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Joe Burrow QB | CIN
Bengals' Joe Burrow: May be eyeing Thanksgiving return
Burrow (toe) won't play Sunday against the Steelers after the Bengals designated him for return from injured reserve Monday, but the quarterback acknowledged that he's hopeful to begin available for Cincinnati's Thanksgiving Day game against the Ravens on Nov. 27, Ben Baby of ESPN.com reports. "We'll see how these next couple weeks go," Burrow said, when asked about a potential return date. "There's a lot that goes into it. There's a lot of variables that you have to consider."
One of those variables will be the Bengals' record as he works his way back from surgery to address a Grade 3 sprain of the big toe on his left foot, a procedure he underwent Sept. 19. In any case, it looks like veteran signal-caller Joe Flacco -- who is managing a shoulder issue of his own -- will draw at least two more starts for the 3-6 Bengals. In his return to practice Monday in a limited capacity, Burrow didn't participate in any 11-on-11 team drills, but he threw some passes to receivers while not facing any defenders.
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Brock Purdy QB | SF
49ers' Brock Purdy: Increasing odds to return to action
Coach Kyle Shanahan said Monday that Purdy (toe) will continue to increase his activity level this week, Nick Wagoner of ESPN.com reports.
As it pertains to Purdy's first appearance since Week 4 due to a turf toe injury, Shanahan told David Lombardi of SFStandard.com that the 49ers "want three aggressive practices [from him], and we want to hear from him and make sure he feels good after them, too." This follows Shanahan's comments from Sunday, in which he relayed that Purdy "hopefully" will "have a chance this week," per Ian Rapoport of NFL Network. Wednesday's injury report ultimately will reveal Purdy's initial activity level for Week 11 prep, but if he's listed as full, it'll be a good indication that he's trending toward a return to action Sunday at Arizona. Mac Jones so far has earned eight spot starts in place of Purdy this season.
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Trey Amos CB | WAS
Commanders' Trey Amos: In line for extended absence
Commanders head coach Dan Quinn said Monday that Amos (lower leg) will miss time after having suffered a fractured fibula during Sunday's loss to the Lions, Ben Standig of Big 100 Washington D.C. reports.
Amos is recovering from an injury severe enough that it could force him to miss the remainder of the 2025 campaign. Expect Washington to officially place Amos on IR in the coming days, and for all of Antonio Hamilton, Mike Sainristil and Noah Igbinoghene to see expanded defensive reps beginning Sunday versus the Dolphins in Madrid.
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Zay Jones WR | HOU
Cardinals' Zay Jones: To be placed on IR
Coach Jonathan Gannon said Monday that Jones will be placed on injured reserve due to an Achilles injury, Bo Brack of GoPHNX.com reports.
Gannon didn't specifically say that Jones tore his Achilles, but he'll miss at least the next four games as a result of the injury that he sustained during Sunday's loss at Seattle. Through eight appearances this season, Jones has hauled in 12 of 18 targets for 183 yards and no touchdowns. Greg Dortch figures to take on a larger role in Jones' absence.
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Daron Payne NT | WAS
Commanders' Daron Payne: Appealing one-game ban
Payne will appeal his one-game suspension, John Keim of ESPN.com reports.
Payne was hit with a one-game suspension after he threw a punch at Amon-Ra St. Brown during Washington's blowout loss to the Lions on Sunday. Payne was ejected from the contest and will not be permitted to travel with the team to Madrid, Spain for Sunday's game against the Dolphins unless he wins his appeal.
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Marlon Humphrey CB | BAL
Ravens' Marlon Humphrey: Could miss a week or two
Ravens coach John Harbaugh said Monday that Humphrey (finger) could miss one or two weeks if his injury requires surgery, but that the team is still evaluating options, Jeff Zrebiec of The Athletic reports.
Baltimore will take a deliberate approach with the injury that prevented Humphrey from finishing Sunday's win over the Vikings further before making a decision on whether or not the starting slot corner will undergo surgery. It's encouraging that even if a procedure is required, Humphrey doesn't appear in line to miss much time, but it would nonetheless be a notable blow if he's unable to suit up for the Ravens' divisional tilt against the Browns in Week 11.
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Trey Hendrickson LB | BAL
Bengals' Trey Hendrickson: Doubtful for Week 11
Coach Zac Taylor said Monday that Hendrickson (hip) is doubtful to play Sunday against the Steelers, Paul Dehner Jr. of The Athletic reports.
Hendrickson wasn't present at practice Monday with the Bengals coming out of their bye week. Hendrickson missed the Bengals' Week 9 game against the Bears prior to the open date and looks poised to miss a second straight contest due to the injury. Through seven games this season, Hendrickson has recorded 16 tackles (11 solo), including 4.0 sacks, one pass breakup and one forced fumble. Following back-to-back 17.5-sack seasons in 2023 and 2024, it's been a down year for the soon-to-be 31-year-old edge rusher.
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Brian Asamoah LB | CIN
Bengals' Brian Asamoah: Signed from practice squad
The Bengals signed Asamoah from the practice squad to the active roster Monday.
Asamoah was elevated off the practice squad for one game with Cincinnati earlier this season, when he played 19 snaps on special teams in Week 9 versus Chicago. He figures to contribute in a similar capacity for the team down the stretch, beginning Sunday on the road against Pittsburgh.