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James Cook III RB | BUF
Bills' James Cook: Shreds Lions defense in win
Cook rushed 21 times for 135 yards and a touchdown and brought in one of three targets for four yards in the Bills' 41-31 win over the Lions on Thursday.
Cook repeatedly gashed a Lions defense that came in with a reputation for being stingy against the run, more than atoning for a lackluster Week 1 showing against the Texans just four days earlier. The star running back rounded out his fantasy night with the final score of the high-scoring clash for the Bills, recording a one-yard touchdown run with just under three minutes remaining in the fourth quarter. Cook's multiple explosive runs throughout the night served as a reminder of why he earned such lofty draft status this summer, and he'll remain a critical component of a juggernaut Bills offense in a Week 3 home matchup against the Chargers on Sunday, Sept. 27.
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Jahmyr Gibbs RB | DET
Lions' Jahmyr Gibbs: Eclipses 100 total yards in loss
Gibbs rushed 16 times for 52 yards and brought in six of eight targets for 61 yards and a touchdown in the Lions' 41-31 loss to the Bills on Thursday.
Gibbs managed a 16-yard run among his 16 carries, yet he generally found running room at a premium over the course of the high-scoring loss. Game script also limited the star running back's opportunities on the ground somewhat, but Gibbs did make up for it to an extent with his work as a receiver. The fourth-year pro tied for second in receptions and also was the runner-up in receiving yards for the Lions on the night, and he added his first receiving touchdown of the season when he brought in an 11-yard laser from Jared Goff with just over five minutes remaining in the first half. Gibbs should have a chance at reverting to a larger workload on the ground in a Week 3 home matchup against the Jets on Sunday, Sept. 27.
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Josh Allen QB | BUF
Bills' Josh Allen: Another elite performance in win
Allen completed 20 of 31 passes for 248 yards with three touchdowns and no interceptions while rushing 14 times for 69 yards and another pair of scores in the Bills' 41-31 win over the Lions on Thursday. He also committed a fumble recovered by Buffalo.
Allen extended his record of most games with two-plus passing touchdowns and two-plus rushing touchdowns, accomplishing the feat for the 10th time in his career while leading the Bills to a wild victory in their first regular-season game at the new Highmark Stadium. His pair of rushing touchdowns came from one and two yards out in the first and third quarters, respectively, and he hit Joshua Palmer (43 yards), Dawson Knox (one yard) and Dalton Kincaid (16 yards) for his trio of scoring strikes. Allen's solid passing numbers were made all the more impressive by the fact he lost DJ Moore to a shoulder injury late in the first half, and the star signal-caller encouragingly displayed strong chemistry with Keon Coleman (6-63-0) in response. Allen has quickly generated a 5:0 TD:INT and added four rushing touchdowns in his first two games, a noteworthy start to a quest for a second career MVP. Allen and his teammates now get some extra rest ahead of a Week 3 home showdown against the Chargers on Sunday, Sept. 27.
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Aaron Banks G | GB
Packers' Aaron Banks: Limited in practice
Banks (knee) was a limited participant in practice Thursday.
The starting left guard was limited Wednesday as well after missing Green Bay's Week 1 loss to Minnesota. Banks was also unable to fully practice ahead of that contest. Donovan Jennings is Green Bay's first backup guard in case Banks can't go this Sunday against the Jets.
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Zach Bako-Bewele G | GB
Packers' Zach Bako-Bewele: Limited again
Bako-Bewele (knee) was a limited participant in practice Thursday.
The starting right tackle was also limited Wednesday. He played through the knee injury in Week 1 but appears to still be dealing with the issue. Bako-Bewele was also limited in practice last week.
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John Simpson G | BAL
Ravens' John Simpson: Sits out of practice
Simpson (groin) did not participate in practice Thursday.
The starting left guard also missed Wednesday's session. Simpson was able to handle all 68 offensive snaps in the Ravens' Week 1 win over the Colts, but he likely picked up the groin injury during the game. If he can't play this Sunday against the Saints, Andrew Vorhees is the next man up.
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Ronnie Stanley OT | BAL
Ravens' Ronnie Stanley: Misses practice again
Stanley (toe) did not participate in practice Thursday.
The starting left tackle also sat out of Wednesday's session. Stanley played for the entirety of the Ravens' Week 1 win over the Colts but emerged from the game with a toe injury. If he can't return to the field for this Sunday's matchup with the Saints, Carson Vinson will likely have to step in.
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Brian O'Neill OT | MIN
Vikings' Brian O'Neill: Sits out of practice
O'Neill (knee) did not practice Thursday.
The starting right tackle was a limited participant a day earlier. O'Neill played on all 65 offensive snaps in Week 1 against Green Bay but emerged from the contest with a knee injury. Now he's trending in the wrong direction as Week 2 approaches.
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Josh Simmons OT | KC
Chiefs' Josh Simmons: Misses another practice
Simmons (back) did not participate at the Chiefs' practice Thursday.
Simmons has missed both of the team's first two practices of the week as he continues to nurse a back issue. The offensive lineman appears to be set to miss a second straight game to open the 2026 campaign, and if that's the case, Kahlil Benson will draw another start at left tackle versus Indianapolis on Sunday night.
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Cole Van Lanen G | JAC
Jaguars' Cole Van Lanen: Remains limited Thursday
Van Lanen (knee) was limited at practice Thursday.
Van Lanen was limited for a second straight day to open the week as he continues to nurse a knee injury. The offensive lineman was limited throughout the entire week before playing in the team's Week 1 win over the Browns, and he appears to be on a similar track prior to Sunday's matchup with Denver.