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Alim McNeill DT | DET
Lions' Alim McNeill: Won't return for Week 6
McNeill (knee) has been ruled out for Sunday's game against the Chiefs, Justin Rogers of DetroitFootball.net reports.
McNeill was a full participant in all three practices for the Lions' Week 6 prep, showing good progress in his recovery from a torn ACL in his right knee that he suffered in December. He hasn't been cleared to return quite yet, but the Lions are targeting Week 7 against the Buccaneers on Monday, Oct. 20 as McNeill's 2025 debut, per Dave Birkett of the Detroit Free Press.
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Bhayshul Tuten RB | JAC
Jaguars' Bhayshul Tuten: Clear for Week 6
Tuten (shoulder) doesn't have a designation for Sunday's contest versus the Seahawks.
Tuten was listed as limited on Wednesday's practice estimate due to a lingering shoulder injury and then had a cap on his reps both Thursday and Friday. However, it won't stop him from continuing to serve as the Jaguars' No. 2 RB behind starter Travis Etienne. Such a role has amounted to 26 touches for 128 yards from scrimmage and two total TDs for Tuten over the last four games.
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Dyami Brown WR | WAS
Jaguars' Dyami Brown: Cleared to face Seahawks
Brown (shoulder) doesn't have an injury designation for Sunday's game against the Seahawks, Demetrius Harvey of the Florida Times-Union reports.
Brown was limited in all three of Jacksonville's practices, but his availability for Sunday's game isn't in doubt. He has cooled off after exceeding 50 receiving yards in each of his first two games with the Jaguars, and Brown's target share is likely to fluctuate moving forward given the presence of Brian Thomas, Travis Hunter and Parker Washington in Jacksonville's deep wide receiver room.
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Brock Bowers TE | LV
Raiders' Brock Bowers: Won't play versus Titans
Bowers (knee) has been ruled out for Sunday's game against the Titans.
Coach Pete Carroll acknowledged earlier Friday that Bowers "isn't quite ready yet," per Levi Edwards of the Raiders' official site, and now that the tight end has been officially ruled out, he'll target a possible return to action Sunday, Oct. 19 versus the Chiefs. In Bowers' absence, Michael Mayer, who has been cleared to return from a concussion, is in line to lead the team's TE corps versus Tennessee, a context that makes him worthy of Week 6 fantasy lineup consideration.
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Miles Sanders RB | DAL
Cowboys' Miles Sanders: Set for season-ending knee surgery
Executive Vice President Stephen Jones said Friday that Sanders will undergo season-ending knee surgery, Todd Archer of ESPN.com reports.
Sanders initially was forced out Week 4 against the Packers due to an ankle injury and then didn't suit up this past Sunday at the Jets due to listed knee and ankle issues. It appears the knee is the greater concern for Sanders following Jones' announcement, and the running back will finish the 2025 campaign with 20 carries for 117 yards and one touchdown and eight catches (on eight targets) for 30 yards in parts of four games. Jaydon Blue will step into the No. 2 role behind starting RB Javonte Williams moving forward.
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Michael Mayer TE | LV
Raiders' Michael Mayer: Opportunity knocks with Bowers out
Mayer (concussion) doesn't have an injury designation for Sunday's game against the Titans, while Brock Bowers (knee) has been ruled out, Ryan McFadden of ESPN.com reports.
Mayer missed the Raiders' previous two games due to a concussion but cleared league protocol earlier in the week and subsequently logged three full practices during Week 6 prep. He's expected to play a significant role in Vegas' passing offense in Bowers' absence.
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Zay Jones WR | HOU
Cardinals' Zay Jones: Questionable for Sunday
Jones (knee) is listed as questionable for Sunday's game at Indianapolis, Bo Brack of GoPHNX.com reports.
Jones' practice reps were capped during the entirety of Week 6 prep due to a knee injury, and his status for Sunday will be clarified about 90 minutes before a 1:00 p.m. ET kickoff. If Jones is able to suit up, who will be under center for the Cardinals is up in the air considering Kyler Murray (foot) managed just one limited practice this week and is listed as questionable. Jacoby Brissett will get the nod at quarterback if Murray is inactive.
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KaVontae Turpin WR | DAL
Cowboys' KaVontae Turpin: Remains sidelined Week 6
Turpin (foot) has been ruled out for Sunday's game against the Panthers.
Turpin will miss a second consecutive game due to a foot injury he suffered Week 4 against the Packers. He has yet to practice since sustaining the injury. Jaydon Blue and Jalen Tolbert are expected to return kickoffs and punts, respectively, in Turpin's absence.
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Zay Flowers WR | BAL
Ravens' Zay Flowers: Questionable after limited practice
Flowers (shoulder) is listed as questionable for Sunday's game against the Rams, Brian Wacker of the Baltimore Sun reports.
Flowers was limited in all three of Baltimore's practices prior to being tagged with a questionable designation for Week 6. Even if Flowers plays, he would be catching passes from backup quarterback Cooper Rush, as Lamar Jackson (hamstring) has been ruled out for a second consecutive game.
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Cooper Rush QB | ATL
Ravens' Cooper Rush: Another spot start on tap
Rush will start Sunday against the Rams after the Ravens ruled out Lamar Jackson (hamstring) for that contest, Brian Wacker of The Baltimore Sun reports.
Earlier Friday, coach John Harbaugh declined to give a game designation for Jackson ahead of Week 6 action but added that if he doesn't play, Rush would get the nod under center, per Jamison Hensley of ESPN.com. Now that the preceding has come to pass, Rush will start his second straight game this weekend, though he'll be looking to be more productive after completing 14-for-20 passes for 179 yards, no touchdowns and three interceptions during this past Sunday's 44-10 loss to the Texans.