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Jeremiyah Love RB | ARI
Cardinals' Jeremiyah Love: Stymied by Lions in loss
Love rushed 12 times for 22 yards and failed to bring in his only target in the Cardinals' 45-21 loss to the Lions on Sunday.
Love's meager rushing yardage total actually led the Cardinals on the afternoon, and game script had essentially turned away from the run by halftime with Arizona already down 24-7 at that point. The rookie first-round pick was on the sideline by the final drive of the afternoon, and Love finished with a new career low in rushing yards. The downturn on the ground was particularly drastic when compared to Love's previous two games, when he'd gained 153 yards on 35 carries against the 49ers and Giants. Love and the Cardinals will have an uphill battle to bounce back in Week 6 as well, as Arizona pays a visit to the Rams next Sunday.
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Matthew Hibner TE | BAL
Ravens' Matthew Hibner: Dealing with hand injury
Hibner (hand) is questionable to return to Sunday night's contest against the Falcons.
Hibner suffered a hand injury in the first quarter, and his availability for the rest of the contest is now uncertain. In his absence, Mark Andrews will continue to handle the lion's share of the workload at tight end.
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Drake Maye QB | NE
Patriots' Drake Maye: Erupts for five TDs in rout
Maye completed 26 of 34 passes for 374 yards and four touchdowns while adding 25 yards and another TD on seven carries in Sunday's 45-17 win over the Raiders.
The second-year QB has completely erased his early-season struggles, leading the Patriots to a 21-7 halftime lead and not taking his foot off the gas the rest of the way. Maye completed at least three passes to six different targets, hitting DeMario Douglas for two of his TDs and tossing one each to Hunter Henry and Kyle Williams, and he added a three-yard score of his own in the third quarter. Maye's rushing touchdown was his first of the year, and seven of his eight passing TDs have come in the last two weeks after he began the campaign with a 1:6 TD:INT over his first three contests. Maye will look to stay locked in for a Week 6 clash with the Jets.
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Sam Darnold QB | SEA
Seahawks' Sam Darnold: One TD, two turnovers in loss
Darnold completed 18 of 29 passes for 195 yards, one touchdown and two interceptions in Sunday's 32-29 loss to the 49ers. He added one rushing attempt for five yards.
Darnold threw another two interceptions, bringing him up to five in three full games this season after he had a league-worst 20 turnovers in the 2025 regular season. His lone touchdown pass was a 16-yarder to Jaxon Smith-Njigba in the third quarter, on which the star wide receiver did most of the work after the catch. Darnold is in no danger of losing the starting job ahead of Thursday's Week 6 home game against the Broncos considering he has earned a long leash coming off a Super Bowl title, but it's worth noting that backup Drew Lock completed 72.9 percent of his passes while playing turnover-free football to lead Seattle to a pair of wins while Darnold was sidelined by a glute injury earlier in the year.
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Darius Cooper WR | PHI
Eagles' Darius Cooper: Another touchdown in Week 5
Cooper caught two of three targets for 71 yards and a touchdown during Sunday's 19-17 loss to the Jaguars.
Cooper was able to reach paydirt again Sunday, securing a 62-yard touchdown on a deep pass from quarterback Jalen Hurts in the second quarter. The wide receiver has taken advantage of a larger workload in the last two weeks with DeVonta Smith (hamstring) sidelined, reeling in five of 10 targets for 104 yards and three touchdowns in Smith's absence. On the year, Cooper has caught seven of 13 targets for 137 yards and four scores over five contests.
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Sam LaPorta TE | DET
Lions' Sam LaPorta: Leads air attack in lopsided victory
LaPorta brought in all five of his targets for 88 yards and a touchdown in the Lions' 45-21 win over the Cardinals on Sunday.
The athletic tight end was a constant presence in the air attack during the high-scoring victory, and he finished with a season-high yardage total that also set the pace for the Lions on the afternoon. LaPorta also contributed his third touchdown of the campaign -- and his second in as many games -- with a 38-yard grab in the second quarter. LaPorta has his two highest yardage tallies of the season in the last two games, which affords him plenty of momentum heading into the Week 6 bye that precedes a Week 7 divisional showdown at home against the Packers on Sunday, Oct. 25.
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Jaylen Waddle WR | DEN
Broncos' Jaylen Waddle: Makes just two catches Sunday
Waddle corralled two of five targets for 19 yards and also had a nine-yard carry during Sunday's 23-17 road win against the Chargers.
Waddle has hit once (8-138-0 on 10 targets in Week 2 against the Jaguars) and otherwise hasn't done much (10-66-1 on 21 targets) in his other four appearances in his first campaign with the Broncos. It didn't help any of Denver's skill-position players that QB Bo Nix's 27 passes went for only 123 yards, and a quick turnaround to face the Seahawks defense Thursday isn't a recipe for Waddle or any of his teammates to turn around their fortunes to begin the 2026 season.
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Fernando Mendoza QB | LV
Raiders' Fernando Mendoza: Sees first NFL action in Week 5 loss
Mendoza completed six of eight passes for 48 yards without a touchdown or turnover in Sunday's 45-17 loss to the Patriots. He added three yards on his only carry.
With the game out of hand, Raiders coach Klint Kubiak elected to give Mendoza his first pro snaps on the team's final drive of the game, and the first overall pick in the 2026 draft acquitted himself well in a low-pressure situation, with his longest completion going for 16 yards to Tre Tucker. Mendoza even led Las Vegas into the red zone, but he came up just short on a fourth-and-4 from New England's 14-yard line as he scrambled for the sticks. It was only a matter of time until Mendoza replaced Kirk Cousins under center on a permanent basis, but a switch may not be imminent with the veteran QB having led the team to a 3-2 record. Mendoza has at least given his coach some early confidence that he'll be ready when the time comes.
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George Kittle TE | SF
49ers' George Kittle: Five short catches in Week 5 win
Kittle (illness) caught five of six targets for 24 yards in Sunday's 32-29 win over the Seahawks.
Kittle had an uncharacteristic third-down drop on San Francisco's opening drive but caught his other five targets to finish second on the 49ers in receiving yards despite playing through an illness. Mike Evans easily led the team with seven catches for 113 yards and a touchdown on 10 targets in Sunday's win. Kittle will have an extra day to recover before the Commanders come to town for Monday Night Football in Week 6.
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Emanuel Wilson RB | SEA
Seahawks' Emanuel Wilson: Posts TD, fumble on 22 touches
Wilson rushed 20 times for 61 yards and a touchdown in Sunday's 32-29 loss to the 49ers. He also caught both of his targets for 11 yards and lost a fumble.
Wilson followed up his two-touchdown performance in Week 4 against the Chargers with a two-yard rushing score in the first quarter against the 49ers, but he proceeded to lose a fumble in the second quarter. Fellow running back George Holani also lost a fumble and Sam Darnold threw two interceptions in a sloppy performance from Seattle's offense. Zach Charbonnet (knee) isn't expected to be activated from the reserve/PUP list ahead of Thursday's game against the Broncos, while Jadarian Price (chest) remains on IR, so Wilson is poised to remain Seattle's lead back in Week 6.