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Nick Bosa DE | SF
49ers' Nick Bosa: Won't play Sunday
Bosa (knee) has been ruled out ahead of Sunday's game against the Falcons.
Coach Kyle Shanahan stated that Bosa was "a little too optimistic" with his statement that he would be back before the bye, David Lombardi of SFStandard.com reported Friday. The defensive end's chances to play were also diminished because Sunday's game in Atlanta is played on artificial turf. Bosa will continue to recover in anticipation of the 49ers' Week 9 matchup with the Raiders.
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Tremaine Edmunds MLB | NYG
Giants' Tremaine Edmunds: Done for 2026
Edmunds will miss the rest of the 2026 season due to a torn chest muscle, Jordan Raanan of ESPN.com reports.
Edmunds suffered the injury late in the fourth quarter of the Giants' 34-27 loss to the Saints in Week 6. With the veteran linebacker done for the year, Micah McFadden will take over as the starter alongside Arvell Reese. Edmunds will finish his first season with the Giants with 50 tackles (32 solo), including 2.0 sacks, and two pass defenses across six regular-season games.
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Andrew Wingard SAF | ARI
Cardinals' Andrew Wingard: Ruled out for Week 7
Wingard (knee) has been ruled out for Sunday's game against the Broncos, Darren Urban of the Cardinals' official site reports.
Wingard will miss a third consecutive game due to a bone bruise in his knee, and his next chance to play is Week 8 against the Cowboys on Sunday, Nov. 1. Budda Baker (groin/illness) is questionable, so Wydett Williams, Dadrion Taylor-Demerson and Kitan Crawford are all candidates to start at safety against Denver on Sunday.
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Nick Emmanwori SAF | SEA
Seahawks' Nick Emmanwori: Questionable with new injury
Emmanwori (hip) is listed as questionable for Sunday's game against the Chiefs, John Boyle of the Seahawks' official site reports.
Emmanwori appeared on Friday's injury report as a limited participant. The slot cornerback managed to partially practice through his knee issue, but it remains unclear if he will be able to play through it in Sunday's contest against the Chiefs. If Emmanwori cannot suit up, the Seahawks may pivot to more base defense to combat former Seahawk and reigning Super Bowl MVP Kenneth Walker's ground presence.
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Max Melton CB | ARI
Cardinals' Max Melton: Questionable vs. Denver
Melton (knee) is questionable for Sunday's game against the Broncos, Darren Urban of the Cardinals' official site reports.
Melton missed the last two practices of the week while tending to a knee injury, but head coach Mike LaFleur said Friday that the third-year defensive back is "trending in a positive direction" ahead of Sunday's game, per Bo Brack of GoPHNX.com. Kalen King would see more defensive snaps if Melton does not play against Denver.
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Budda Baker S | ARI
Cardinals' Budda Baker: Chance to play against Denver
Baker (groin/illness) is questionable for Sunday's game against the Broncos, Darren Urban of the Cardinals' official site reports.
Baker was held out of each of the first two practices due to an illness and groin injury, but he earned the questionable tag after logging a limited session Friday. Wydett Williams and Dadrion Taylor-Demerson would be the top candidates to start at safety if Baker cannot play.
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Carson Beck QB | ARI
Cardinals' Carson Beck: Questionable for Week 7
Beck (back) is questionable for Sunday's game against the Broncos, Darren Urban of the Cardinals' official site reports.
Beck was unable to practice Thursday and Friday while working through back spasms, per Tyler Drake of ArizonaSports.com. He's been the emergency QB3 in each of the Cardinals' first six games of the season, and since Arizona doesn't have another quarterback on the practice squad, the team could just roll with starter Jacoby Brissett and backup Gardner Minshew for Sunday's contest.
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Brandin Cooks WR | SF
49ers' Brandin Cooks: May take over No. 1 WR role Sunday
Cooks could be set to work as San Francisco's top wideout Week 7 against Atlanta, as both Mike Evans (Achilles) and Deebo Samuel (hamstring) have been ruled out for the contest, per Brooke Evans of the team's official site.
Cooks logged a season-high 52 percent offensive snap share in Monday's win over Washington while Samuel was sidelined, and now Evans is set to miss at least one game as well. Cooks managed just one catch on two targets for 13 yards across his 32 offensive snaps, however, as QB Brock Purdy directed a majority of his 29 passes to tight end George Kittle (eight targets) and running back Christian McCaffrey (10 targets). Kittle and McCaffrey could be looked to often again in Week 7, with Cooks, Jordan Watkins, Jacob Cowing and Christian Kirk (calf) potentially competing for WR targets.
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Drake Thomas LB | SEA
Seahawks' Drake Thomas: Set to miss consecutive weeks
Thomas (ankle) has been ruled out ahead of Sunday's game against the Chiefs, John Boyle of the Seahawks' official site reports.
Thomas was unable to practice throughout Week 7 prep and has subsequently been ruled out ahead of Sunday's game. The inside linebacker will once again be replaced by Tyrice Knight. Ernest Jones and Knight will have a tough week taking on former teammate and reigning Super Bowl MVP Kenneth Walker.
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Talanoa Hufanga SAF | DEN
Broncos' Talanoa Hufanga: Will be sidelined for Week 7
Hufanga (ankle) has been ruled out for Sunday's game against the Cardinals.
Hufanga was held out of practice all week due to an ankle injury, which he picked up during the Broncos' Week 5 win over the Chargers. He'll be sidelined for a second consecutive game, and his next opportunity to play is Week 8 against the Chiefs on Sunday, Nov. 1. Devon Key and Jahdae Barron will both continue to see more work in the secondary in Hufanga's absence.