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Tyler Goodson RB | DAL
Colts' Tyler Goodson: Misses Wednesday's practice
Goodson (groin) didn't participate in Wednesday's practice, James Boyd of The Athletic reports.
Goodson sustained a groin injury in the Colts' Week 4 win loss to the Rams and hasn't returned to practice since. The Iowa product has played just 24 snaps (16 on special teams, eight on offense) across two appearances this season, rushing twice for six yards. He likely needs to upgrade to at least limited practice Thursday or Friday to have a chance at suiting up for the Week 6 matchup against the Cardinals.
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Jaylen Warren RB | PIT
Steelers' Jaylen Warren: Practicing again
Warren (knee) is practicing Wednesday, Alan Saunders of SteelersNow.com reports.
Warren has a sleeve over his injured knee but appears to be going through drills at full speed. He returned to practice Monday after a Week 5 bye and Week 4 absence. Kenneth Gainwell stepped up with 25 touches for 134 yards and two TDs in the Week 4 win over Minnesota, potentially earning a larger role moving forward (relative to his limited usage in Weeks 2-3).
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Nakobe Dean LB | LV
Eagles' Nakobe Dean: Could return Thursday
Dean (knee) is listed as questionable ahead of Thursday night's matchup against the Giants.
The Georgia product logged another full practice Wednesday but must still be activated to the Eagles' active roster in order to play Thursday night. If Dean is activated in time for the Week 6 divisional matchup, he's likely to serve as Philadelphia's top reserve inside linebacker, playing behind Zack Baun and rookie Jihaad Campbell.
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Jihaad Campbell LB | PHI
Eagles' Jihaad Campbell: Past biceps issue
Campbell (biceps) has no injury designation ahead of Thursday night's matchup against the Giants.
The rookie linebacker from Alabama upgraded from limited practice Tuesday to a full session Wednesday, suggesting he's moved past his biceps injury in time to face the Giants on Thursday night. Campbell has impressed through his first five NFL games, recording 33 total tackles and two passes defended, including one interception. Now healthy, he's expected to start alongside Zack Baun as part of Philadelphia's top inside linebacker tandem.
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Kimani Vidal RB | LAC
Chargers' Kimani Vidal: Signed to roster
The Chargers signed Vidal to their active roster Wednesday.
He'll take the place of Omarion Hampton, who was placed on injured reserve after suffering an ankle injury late in the third quarter of Sunday's loss to the Commanders. Vidal and Hassan Haskins formed a near 50/50 split on the next drive, with Vidal then taking over on the final series once Justin Herbert and other starters had been pulled. Vidal was a practice-squad promotion for Weeks 4 and 5 -- after Najee Harris suffered a season-ending injury -- but will now reside on the active roster and have a role in the Week 6 game plan against a struggling Miami defense.
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Jalen Carter DT | PHI
Eagles' Jalen Carter: Questionable for Week 6
Carter (heel) is listed as questionable ahead of Thursday night's matchup against the Giants.
The 24-year-old popped up on the Eagles' injury report Wednesday as a limited practice participant due to a heel issue, leaving his status for Thursday night's divisional matchup up in the air. Carter played through a heel injury in the Week 5 loss to the Broncos, recording four total tackles across 66 defensive snaps. However, if the issue worsened and he's unable to suit up in Week 6, Za'Darius Smith would likely see increased work with the Eagles' first-team defensive line.
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Omarion Hampton RB | LAC
Chargers' Omarion Hampton: Placed on IR
The Chargers placed Hampton (ankle) on injured reserve Wednesday, Daniel Popper of The Athletic reports.
With Hampton out for at least four games, the Chargers are signing Kimani Vidal to their active roster and Nyheim Hines to the practice squad. Vidal and Hassan Haskins split backfield snaps after Hampton's early exit from a loss to the Commanders this past Sunday.
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Grant Calcaterra TE | PHI
Eagles' Grant Calcaterra: Out for Thursday night
Calcaterra (oblique) has been ruled out ahead of Thursday night's matchup against the Giants.
The 2022 sixth-round pick from SMU sustained an oblique injury in the Eagles' Week 5 loss to the Broncos, limiting him to just seven offensive snaps. He didn't practice all week and is now in line to miss his first contest of the 2025 season. While Calcaterra is sidelined Thursday night, Kylen Granson is expected to operate as Philly's No. 2 tight end.
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Landon Dickerson G | PHI
Eagles' Landon Dickerson: Won't play in Week 6
Dickerson (ankle) has been ruled out ahead of Thursday night's matchup against the Giants.
Dickerson was unable to practice all week due to the ankle injury sustained in Philadelphia's Week 5 loss to the Broncos, so it's no surprise he's been ruled out for Thursday's contest. Brett Toth is expected to start at left guard in Dickerson's stead in Week 6.
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Saquon Barkley RB | PHI
Eagles' Saquon Barkley: Ready for Thursday Night Football
Barkley (knee) was a full participant in Wednesday's practice and has been cleared to suit up Thursday against the Giants.
Barkley is ready to suit up for Thursday's divisional match after having been estimated as a non-participant Monday and as limited during Tuesday's walk-through. The star running back has reportedly dealt with general soreness in his knee, and he played a season-low 72 percent of offensive snaps Week 5 while carrying the ball just six times for 30 rushing yards. Given that context, it's possible his workload could be managed Thursday night coming off a short week of practice.