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Jeremy McNichols RB | WAS
Commanders' Jeremy McNichols: Listed as limited
McNichols was a limited practice participant Wednesday due to a hamstring injury.
McNichols wasn't listed on the injury report last week, when he took 20 percent of snaps but finished without a touch in a 27-18 loss to the Packers on Thursday. Fellow running back Austin Ekeler suffered an Achilles tear in the fourth quarter, opening up room for McNichols to get more work moving forward, though likely as part of a three-man backfield with Jacory Croskey-Merritt and Chris Rodriguez. A hamstring injury could complicate things, but McNichols still has a few more chances to practice in full before Sunday's matchup with the Raiders.
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Ifeatu Melifonwu SAF | TB
Dolphins' Ifeatu Melifonwu: Officially out for Week 3
Melifonwu (calf) is ruled out for Thursday's road game against the Bills, Marcel Louis-Jacques of ESPN.com reports.
Melifonwu suffered a calf injury Week 2 against the Patriots and hasn't resumed practicing in any capacity since, making it unsurprising to see him now ruled out for Thursday Night Football. In his stead, Ashtyn Davis looks set to start alongside Minkah Fitzpatrick versus Buffalo. Melifonwu's next opportunity to retake the field will come Monday, Sept. 29 versus the Jets.
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Josh Jacobs RB | GB
Packers' Josh Jacobs: Tending to ankle issue
Jacobs was limited in practice Wednesday due to an ankle injury, Matt Schneidman of The Athletic reports.
The Packers' ground game has struggled to get going through two contests, but Jacobs still has churned out 150 yards and two touchdowns on 42 carries while hauling in his only target for four yards. Coming off nearly a week of rest since last Thursday's win against the Commanders, though, Jacobs wasn't able to handle a full allotment of reps Wednesday as Green Bay prepares for Sunday's contest at Cleveland.
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Khalil Mack OLB | LAC
Chargers' Khalil Mack: Out at least four games
The Chargers placed Mack (elbow) on injured reserve Wednesday.
Mack has at least avoided a season-ending injury, with Ian Rapoport of NFL Network reporting that the veteran edge rusher suffered a dislocated elbow in Monday night's 20-9 win over the Raiders but is expected to miss only a few weeks. He'll be forced to sit out at least four games due to being placed on IR, making Week 7 against the Colts on Sunday, Oct. 19 the earliest possible date for Mack's return. Until Mack is back in action, Bud Dupree is expected to step into a starting role opposite Tuli Tuipulotu.
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Chris Godwin WR | TB
Buccaneers' Chris Godwin: Listed as limited participant
Godwin (ankle) was a limited participant in Wednesday's practice.
He practiced for the first time last Thursday before returning to non-activity Friday. Godwin's second instance of official practice participation is a positive sign, but reports earlier this month suggested he's unlikely to play before October and is being kept on the active roster only to practice and ramp up with teammates (rather than being restricted to a side field while on an injury list). The Buccaneers, however, haven't said anything of the sort publicly, instead waiting for the final injury report to rule Godwin out in Weeks 1 and 2.
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Storm Duck CB | MIA
Dolphins' Storm Duck: Ruled out to face Bills
Duck (ankle) is ruled out for Thursday's road game against Buffalo, Marcel Louis-Jacques of ESPN.com reports.
Duck hasn't yet resumed practicing since leaving the field early due to an ankle injury Week 1. His next opportunity to retake the field will come Week 4 against the Jets on Monday, Sept. 29. With Duck still unavailable, veteran Rasul Douglas will again handle expanded defensive snaps at outside cornerback Thursday versus the Bills.
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Emeka Egbuka WR | TB
Buccaneers' Emeka Egbuka: Doesn't practice Wednesday
Egbuka didn't practice Wednesday due to hip and groin injuries.
The rookie first-round pick has kicked off his pro career with a bang, combining for three touchdown catches in his first two games. Overall, he has eight receptions (on 13 targets) for 96 yards and the aforementioned scores. There's no telling if the new health concerns are threatening his availability for Sunday's contest against the Jets, but his activity level Thursday and Friday likely will provide insight in that regard.
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D'Andre Swift RB | CHI
Bears' D'Andre Swift: Dealing with quad concern
Swift practiced in a limited capacity Wednesday due to a quadriceps injury.
Swift has kicked off the 2025 season in his typical role as the Bears' No. 1 running back, turning 29 carries into 116 yards (4.0 YPC) and one touchdown and six catches (on eight targets) into 18 yards through two contests. Meanwhile, rookie seventh-round pick Kyle Monangai has combined for nine touches in that same span. With an injury now in tow, though, Swift's status will be one to watch as the week goes on to ensure he'll be out there Sunday against the Cowboys.
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Josh Reynolds WR | NYJ
Jets' Josh Reynolds: Still not practicing
Reynolds (hamstring) did not practice Wednesday, Rich Cimini of ESPN.com reports.
Reynolds hasn't practiced since last Thursday, putting him potentially at risk of missing a second consecutive game and being forced to sit out Sunday's contest against the Buccaneers, in which Tyrod Taylor is slated to start in place of an injured Justin Fields (concussion). When healthy Week 1, Reynolds secured two of three targets for 18 yards while playing 97 percent of New York's offensive snaps.