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Jonathan Taylor RB | IND
Colts' Jonathan Taylor: Strong numbers in lopsided loss
Taylor rushed 19 times for 98 yards and two touchdowns and brought in three of four targets for 23 yards in the Colts' 41-23 loss to the Ravens on Sunday. He also lost a fumble.
Taylor and the Colts' offense as a whole got the new season off to a highly encouraging start, capping off a crisp opening drive with the star running back's one-yard touchdown run. Taylor would go on to add a three-yard scoring rush late in the first half after the Ravens had gone on to rattle off 28 straight points, with Taylor's fumble after a 14-yard reception leading to one of Baltimore's touchdowns. Outside of the turnover, Taylor's overall numbers in a game during which his rushing opportunities were capped late were still useful for fantasy managers, and he'll be slated for another prominent role in a Week 2 road showdown against the Chiefs next Sunday night.
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James Cook III RB | BUF
Bills' James Cook: Held in check by Houston
Cook rushed 13 times for 57 yards and caught three of four targets for 12 yards in Sunday's 36-31 win over the Texans.
Cook didn't find much room against Houston's stout front and took a back seat to Josh Allen, who had two rushing touchdowns and two touchdown passes. Allen's presence didn't stop Cook from rushing for a league-high 1,621 rushing yards during the 2025 regular season, so there should be better days ahead for Buffalo's shifty running back. Cook will have a short turnaround before Buffalo's home opener against the Lions on Thursday.
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Kyler Murray QB | MIN
Vikings' Kyler Murray: Being evaluated for concussion
Murray is undergoing a concussion evaluation after taking a hard hit in Sunday's Week 1 matchup versus the Packers.
Murray was dealt a blow to the head by Javon Bullard on a play that drew an unnecessary roughness penalty. The Vikings quarterback immediately went to the locker room to be evaluated for a concussion. Carson Wentz replaced Murray behind center for Minnesota and will direct the Vikings' offense moving forward if Murray is unable to return.
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Chase Brown RB | CIN
Bengals' Chase Brown: Gets into end zone in win
Brown rushed 16 times for 56 yards and a touchdown and brought in five of six targets for 22 yards in the Bengals' 33-27 win over the Buccaneers on Sunday.
As his final line indicates, Brown unsurprisingly found running room at a premium against the Buccaneers' typically stingy front. Nevertheless, head coach Zac Taylor stuck with the ground attack throughout the afternoon, and Brown, as expected, comfortably outpaced backfield mate Samaje Perine by 11 carries. The versatile back recorded his one touchdown from five yards out with just under six minutes remaining in the second quarter, and he finished tied for the team lead in receptions while also serving as co-runner-up in targets. Brown's busy afternoon should be the norm for him this season, and he'll look to grind out some tough yards again in a Week 2 road showdown against the Texans next Sunday.
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Ja'Marr Chase WR | CIN
Bengals' Ja'Marr Chase: Quiet start to season
Chase brought in two of four targets for 12 yards in the Bengals' 33-27 win over the Buccaneers on Sunday.
Despite the Bengals shaking off their usual Week 1 offensive doldrums, it was still a relatively modest day for the air attack. Joe Burrow threw for a respectable 254 yards, but Chase wasn't prioritized anywhere near the norm and actually finished behind all of Mike Gesicki, Tee Higgins and Chase Brown in targets. Chase will continue to be the focal point of opposing defenses every week, but he should be in line for more opportunity in a Week 2 road matchup against a Texans defense that was surprisingly gashed by the Bills on Sunday.
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Nico Collins WR | HOU
Texans' Nico Collins: Paces Houston with 75 receiving yards
Collins caught seven of 10 targets for 75 yards and a touchdown while adding a seven-yard run in Sunday's 36-31 loss to the Bills.
C.J. Stroud connected with Collins for a 12-yard touchdown in the second quarter, marking the first touchdown of the season for both Houston's quarterback and the team's star wide receiver. Collins led the Texans in targets, catches and receiving yards Sunday after finishing as Houston's receiving yards leader in each of the previous three regular seasons. He is locked in as Stroud's top target heading into a Week 2 home game against the Bengals.
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Marcus Epps SAF | PHI
Eagles' Marcus Epps: Questionable to return with shoulder issue
Epps (shoulder) is questionable to return to Sunday's game against the Commanders.
Epps exited the first quarter of Sunday's divisional contest. If the starter cannot return to the contest, Michael Carter will likely take over at strong safety for the remainder of the game.
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David Montgomery RB | HOU
Texans' David Montgomery: Three total TDs in Texans debut
Montgomery rushed 20 times for 60 yards and two touchdowns while catching all three of his targets for 19 yards and a touchdown in Sunday's 36-31 loss to the Bills.
Montgomery scored Houston's first two touchdowns of the season with a one-yard run in the first quarter followed by an 18-yard run in the second. The offseason trade acquisition from Detroit added a third touchdown on a seven-yard catch as the Texans pulled ahead 28-27 early in the fourth quarter, but Houston's vaunted defense failed to hold that lead. Montgomery's 23 touches in his Texans debut were more than he had in any of his 17 regular-season appearances in 2025 for Detroit, where he had to share the backfield with Jahmyr Gibbs. Woody Marks had 10 touches for 40 yards in a change-of-pace role behind Montgomery, but the latter is clearly Houston's top running back heading into a Week 2 home game against the Bengals.
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Garrett Wilson WR | NYJ
Jets' Garrett Wilson: Leading receiver in Week 1 win
Wilson caught six of seven targets for 79 yards in Sunday's 23-10 win over the Titans.
Wilson paced the team in targets, catches and receiving yards while no teammate exceeded three targets as the Jets employed a run-heavy approach while playing from ahead. Poor QB play and a knee injury limited Wilson to a career-low 395 receiving yards in seven appearances last season, but he had at least 1,042 receiving yards in each of his first three campaigns. Wilson is set to continue working as the top target for offseason acquisition Geno Smith in Week 2 against the Packers.