The Cleveland Cavaliers will face off against the Los Angeles Lakers at 7 p.m. ET on Wednesday at Rocket Mortgage FieldHouse. Cleveland is 4-0 overall and 1-0 at home, while Los Angeles is 3-1 overall and 0-1 on the road. The Lakers have dominated this series in recent years, winning seven of the past 10 meetings against Cleveland. 

This time around, the Cavaliers are favored by 4.5 points in the latest Cavaliers vs. Lakers odds, and the over/under is 225.5 points. Before entering any Lakers vs. Cavaliers picks, you'll want to see the NBA predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 2 of the 2024-25 NBA season on a sizzling 98-63 roll on all top-rated NBA picks dating back to last season, returning more than $2,900. Anyone following at sportsbooks and on betting apps has seen huge returns.  

The model has set its sights on Los Angeles-Cleveland. You can head to SportsLine to see its picks. Here are several NBA betting lines for the game:

  • Cavaliers vs. Lakers spread: Cavaliers -4.5
  • Cavaliers vs. Lakers over/under: 225.5 points
  • Cavaliers vs. Lakers money line: Cavaliers -188, Lakers +157
  • Cavaliers vs. Lakers picks: See picks here

Why the Cavaliers can cover

The Cavaliers managed a 110-104 victory over the Knicks in their last outing. The win came about thanks to a strong surge starting at the 4:29 mark of the third quarter when Cleveland was facing a 72-59 deficit.

Among those leading the charge for Cleveland was Darius Garland, who went 12 for 19 en route to 34 points plus two steals and two blocks. What's more, he also knocked down five 3-pointers, the most he's had since back in March. The Cavaliers are averaging 123.5 points per game this season, the third-most in the NBA. See which team to pick here. 

Why the Lakers can cover

Meanwhile, the point spread may have favored the Lakers last Monday, but the final result did not. They fell to the Suns 109-105. Los Angeles was up 26-8 in the first quarter but couldn't hold on to the lead.

Despite their defeat, the Lakers saw several players rise to the challenge and make noteworthy plays. Anthony Davis, who dropped a double-double with 29 points and 15 rebounds, was perhaps the best of all. Davis' evening made it six games in a row in which he has scored at least 30 points. LeBron James registered 11 points, eight assists and five rebounds in the loss to the Suns. See which team to pick here. 

How to make Lakers vs. Cavaliers picks

The model has simulated Cavaliers vs. Lakers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that hits in over 60% of simulations. You can only see the pick at SportsLine.

So who wins Lakers vs. Cavaliers, and which side of the spread hits over 60% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that was on a 98-63 roll on top-rated NBA picks last season, and find out.