While the top two seeds of the 2025 NFL playoff bracket are on bye, the top two seeds of the 2025 Wild Card Weekend NFL schedule will kick off Sunday. Buffalo and Philadelphia are guaranteed at least two postseason home games if they advance, and both will host their openers on Sunday. Bills vs. Broncos at 1 p.m. ET has Buffalo favored by 8.5 points, per the Super Wild Card Weekend NFL odds, with an over-under of 47. Then, Eagles vs. Packers at 4:30 p.m. ET has the Eagles as 4.5-point favorites, according to the Wild Card NFL spreads.
While this will be the first Broncos vs. Bills matchup of the season, Packers vs. Eagles took place in Week 1 in Brazil. Philadelphia won and covered in a game in which Packers quarterback Jordan Love got hurt, and he also was knocked out of his Week 18 contest with an elbow injury. How does what happened 18 weeks ago in Brazil, and Love's ailment, affect your Wild Card Weekend NFL bets? All of the Super Wild Card Weekend NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Wild Card Weekend NFL picks now.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2025 NFL playoffs on a 31-14 betting hot streak on top-rated NFL picks this year -- a stunning 69% success rate. Longer term, it is on a 211-142 roll on top-rated NFL picks that dates back to the 2017 season and a 65-35 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps could have seen strong returns.
Now, it has turned its attention to the latest Super Wild Card Weekend NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick.
Top Super Wild Card Weekend NFL predictions
We can tell you one of the model's strongest Super Wild Card Weekend NFL picks is that the Rams (+1.5, 47) cover at home versus Minnesota on Monday Night Football. Los Angeles has the rest advantage after it sat its top players like Matthew Stafford, Kyren Williams and Puka Nacua in Week 18, while Minnesota exhausted itself in a 31-9 loss to a physical Detroit team. This game is also a rematch of their Week 8 matchup -- in which Minnesota was also coming off a defeat to the Lions -- and the Rams exploited a worn-down Vikings team by prevailing 30-20, also covering as 3-point underdogs.
Sam Darnold has had a phenomenal season, but he's also never played in a postseason game, and in a playoff-like atmosphere in Week 18, Darnold had zero touchdowns, with his lowest completion percentage of the year. Meanwhile, Stafford is a Super Bowl champion who has multiple touchdown passes in each of his last five playoff games. He enters Monday night with wins in each of his last five starts of this season, and no team has a hotter defense than the Rams over the last few weeks.
Excluding Week 18 when they sat their starters, the Rams have allowed under 10 points in each of their last three games. For the season, L.A. ranks fifth in redzone defense and hasn't allowed a rushing touchdown to an opposing running back since Week 12. The model projects Los Angeles to contain Minnesota's run game, force Darnold into an interception and sack him three times. Limiting the Vikings' offense allows the Rams (+2) to cover over 50% of the time, with the Under hitting in over 50% of simulations. See which other teams to pick here.
How to make Super Wild Card Weekend NFL picks
The model has also made the call on who wins and covers in every other game on the Wild Card Weekend NFL schedule and just revealed two teams that outright win well over 70% of the time, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So what NFL picks can you make with confidence, and which two teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
Super Wild Card Weekend NFL betting odds, lines, live spreads, scores
Get Wild Card Weekend NFL picks at SportsLine
| Game | Spread | Total | Picks |
| Chargers at Texans (Saturday) | LAC -3 | 42.5 | SEE PICKS HERE |
| Steelers at Ravens (Saturday) | BAL -9.5 | 43.5 | SEE PICKS HERE |
| Broncos at Bills | BUF -8.5 | 47 | SEE PICKS HERE |
| Packers at Eagles | PHI -4.5 | 45.5 | SEE PICKS HERE |
| Commanders at Buccaneers | TB -3 | 50.5 | SEE PICKS HERE |
| Vikings at Rams (Monday) | MIN -1.5 | 47 | SEE PICKS HERE |
Where to bet NFL games
Here are some of the sportsbooks to bet on NFL games this week, along with the various NFL sportsbook promos they currently offer.
