The Indianapolis Colts (0-1) hit the road looking for their first win of the season when they head to Lambeau Field to take on the Green Bay Packers (0-1). The Colts came up short against the Houston Texans in Week 1, losing to their AFC South rivals 29-27. The Packers are also looking for their first win of the season after losing to the Philadelphia Eagles 34-29 in the NFL Brazil Game. Jordan Love (knee) is doubtful for Green Bay.
Kickoff at Lambeau Field in Green Bay, Wis., is scheduled for 1 p.m. ET. Indianapolis is favored by 2.5 points in the latest Packers vs. Colts odds from SportsLine consensus, and the over/under is 40.5 points. Before locking in any Colts vs. Packers picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2024 NFL season on an incredible 184-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 38-22 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
The model has set its sights on Packers vs. Colts and just locked in its picks and NFL Week 2 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for spread, money line and over/under:
- Packers vs. Colts spread: Colts -2.5
- Packers vs. Colts over/under: 40.5 points
- Packers vs. Colts money line: Colts -141, Packers +120
- Packers vs. Colts picks: See picks at SportsLine
Why the Colts can cover
Colts quarterback Anthony Richardson has a skillset that will make things incredibly difficult for opposing defensive coordinators. The second-year pro from Florida is a true dual-threat quarterback, who has one of the strongest arms in the league. In Week 1, Richardson completed 9 of 19 passes for 212 yards, two touchdowns and one interception. He also led the Colts in rushing with 56 yards and a touchdown on six carries.
The Colts also have a game-changer at running back in Jonathan Taylor. The former Wisconsin star led the NFL in rushing in 2021, and is a true three-down running back. With Indianapolis' offensive line still among the better groups in the league, Taylor could be in for a big day against Green Bay's defense, which allowed Saquon Barkley to rush for 109 yards and two touchdowns in Week 1. See which team to pick here.
Why the Packers can cover
The Packers will likely be without Love, which is obviously a massive blow to the team's offensive attack. Malik Willis will likely start in his place, and while he is still considered raw, he does have three career NFL starts. Willis was a third-round pick out of Liberty in 2022.
The Packers have plenty of offensive talent that should make things easier for Willis on Sunday. Second-year pro Jayden Reed was outstanding in Green Bay's season opener. The former Michigan State wide receiver caught four passes for 138 yards and touchdown, and also scored a 33-yard rushing touchdown. See which team to pick here.
How to make Packers vs. Colts picks
The model has simulated Packers vs. Colts 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the model's pick at SportsLine.
So who wins Colts vs. Packers in Week 2, and which side of the spread cashes well over 50% of the time? Visit SportsLine now to see which side of the Colts vs. Packers spread to back, all from the model that has returned well over $7,000 on top-rated NFL picks, and find out.
