The Week 5 college football schedule brings with it an SEC matchup that should be one of the biggest games of the year in any conference. The No. 4 Alabama Crimson Tide, in their first season in almost two decades without Nick Saban at the helm, welcome the No. 2 Georgia Bulldogs to Tuscaloosa for a meeting of heavyweights. Georgia is favored by 2 points on the road in the latest Week 5 college football odds via the SportsLine consensus and will hope to reclaim its spot at the top of the AP Top 25 after being surpassed by Texas in recent weeks.

Other notable matchups on the Week 5 college football schedule include No. 20 Oklahoma State at No. 23 Kansas State (-4.5), No. 15 Louisville at No. 16 Notre Dame (-6) and No. 19 Illinois at No. 9 Penn State (-18). So where can you find value in the Week 5 college football lines as you fill out your CFB parlays? Before locking in any Week 5 college football picks, be sure to see the top Week 5 college football expert picks, predictions and best bets from Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. Over the past two college football seasons, Casale is 122-92-5 (57%) overall on his college football picks and 26-8 (76.4%) in bowl games -- all publicly documented. Anybody who has followed him is way up.

Now, he has turned his attention to the Week 5 college football odds and is sharing his top three best bets over at SportsLine. If you parlay them together, you could be looking at a return of around 6-1. Get his top college football picks at SportsLine.

Top Week 5 college football expert predictions

One of Casale's top Week 5 college football picks: He is backing Rutgers (-2.5) against Washington on Friday night. The Huskies went to the 2024 College Football Playoff National Championship Game, but no program has suffered heavier losses than Washington. Kalen DeBoer left this offseason to fill the vacancy at Alabama when Nick Saban retired and new head coach Jedd Fisch had to completely retool the roster when he arrived.

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Meanwhile, Rutgers welcomed back nearly three-quarters of its production from a 7-6 team in 2023. Greg Schiano's squad is off to a 3-0 start that was highlighted by a win at Virginia Tech last week and now the Scarlet Knights will be eager to welcome Washington to the Big Ten. Kyle Monangai has rushed for 457 yards and five touchdowns in three games and he'll have a chance to prove himself as one of the conference's premier players.

"I had this game circled over the summer and I'm thrilled to get Rutgers laying less than a field goal at home. This is a great spot for the Scarlet Knights," Casale told SportsLine. "Piscataway will be rocking Friday night for one of Rutgers' biggest games in years. Look for Greg Schiano to get the guys chopping wood and cover the short number at home." See what other picks Casale likes at SportsLine

How to make Week 5 college football picks 

Casale has also found two other college football picks he loves, including backing a potent offense in a game where "both teams should struggle to get stops." You can only see his picks at SportsLine.

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What are the best bets for Week 5 of college football, and which offense you trust to come out ahead in a high-scoring battle? Visit SportsLine now to see Thomas Casale's college football best bets, all from a proven college football handicapper who has gone 26-8 on bowl games the past two seasons, and find out.