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Brady House 3B | WAS
Nationals' Brady House: Batting third against lefty
House will start at third base and bat third in Thursday's opener versus the Cubs.
The righty-swinging House will likely hit toward the bottom of the batting order against right-handed pitching, but he'll occupy a prime spot in the lineup versus lefty Matthew Boyd. House stung the ball in spring training, slashing .429/.444/.786 with three home runs, though his usual plate-discipline issues (1:11 BB:K) remained.
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Tyler Kinley RP | DET
Braves' Tyler Kinley: Set for setup role
Kinley will begin the season as part of Atlanta's bullpen, Chad Bishop of The Atlanta Journal-Constitution reports.
No surprise here after Kinley posted a 0.72 ERA, 0.68 WHIP and 22:6 K:BB over 25 innings for Atlanta last season following his trade from the Rockies, and then re-signed with the NL East squad on a one-year, $4.5 million deal this offseason. Raisel Iglesias and Robert Suarez will be the top right-handed high-leverage arms for Atlanta, but Kinley could still post strong a strong holds total as one of the primary options for the seventh inning -- his career high in holds is 15, set in 2024 for Colorado.
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Luis Garcia 1B | NYY
Nationals' Luis Garcia: Sitting against left-hander
Garcia is not in the lineup for Thursday's opener against the Cubs.
With left-hander Matthew Boyd toeing the rubber for the Cubs, the lefty-swinging Garcia will yield to Andres Chaparro at first base and Nasim Nunez at second base. Garcia is a career .237/.260/.331 hitter versus southpaws.
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Michael Conforto RF | CHC
Cubs' Michael Conforto: Not starting Thursday
Conforto is out of the lineup for Thursday's game against the Nationals.
The veteran outfielder was expected to open the season as Chicago's primary right fielder versus right-handed pitching with Seiya Suzuki (knee) on the injured list, but Matt Shaw will instead receive the Opening Day nod. Conforto could still get semi-regular opportunities, but between Shaw and Dylan Carlson, there's strong competition for playing time.
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Gavin Sheets 1B | SD
Padres' Gavin Sheets: In lineup against southpaw
Sheets will start at first base and bat sixth in Thursday's opener versus the Tigers.
Padres manager Craig Stammen said prior to spring training that the left-handed-hitting Sheets would play a lot against left-handed pitching. San Diego added righties Nick Castellanos and Ty France to the roster after that declaration, but Stammen is sticking to his guns with Sheets on Opening Day even as the Tigers send ace southpaw Tarik Skubal to the hill. Sheets -- who had a .669 OPS against lefties in 2025 and a .557 OPS versus them in his career -- will likely need to get off to a good start against left-handers to avoid falling into a platoon role.
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Nick Castellanos RF | SD
Padres' Nick Castellanos: Not starting versus lefty
Castellanos is absent from the lineup in Thursday's opener versus the Tigers.
Left-hander Tarik Skubal is on the bump for the Tigers, but the right-handed-hitting Castellanos will yield to lefty Gavin Sheets at first base and righty Miguel Andujar at designated hitter. It's an indication that the former Phillies castoff's playing time will be sporadic in San Diego.
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Matt Shaw RF | CHC
Cubs' Matt Shaw: Starting Opening Day in RF
Shaw is starting in right field and batting ninth in Thursday's season opener against the Nationals.
Michael Conforto was expected to step in as the Cubs' primary right fielder versus right-handed pitching with Seiya Suzuki (knee) on the injured list, but Shaw will instead get the call Opening Day against Washington righty Cade Cavalli. Shaw almost exclusively played third base as rookie last season, but he prepared to fill a super-utility role during the offseason and will immediately get a look at one of his new positions Thursday. The 24-year-old struggled to a .689 OPS in 126 regular-season games last year in his first taste of the majors but is coming off a strong spring training, during which he batted .320/.417/.500 in 60 plate appearances.
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Masyn Winn SS | STL
Cardinals' Masyn Winn: Hitting cleanup Opening Day
Winn is starting at shortstop and batting cleanup in Thursday's opener versus the Rays.
Winn is an atypical cleanup hitter -- this will be just his fourth career start in the slot -- but the rebuilding Cardinals don't have many middle-of-the-order options. It's a boost for Winn's RBI outlook, as he should have chances to drive in runs with JJ Wetherholt, Ivan Herrera and Alec Burleson batting ahead of him.
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Nathan Church CF | STL
Cardinals' Nathan Church: Starting in left field in opener
Church is starting in left field and hitting seventh in Thursday's opener against the Rays.
Church is lined up to receive the bulk of the reps in left field versus right-handed pitching for the Cardinals while Lars Nootbaar (heels) is shelved. Nootbaar was placed on the 60-day injured list Wednesday, so Church should receive an extended look. Thomas Saggese and Jose Fermin are also in the left-field mix for St. Louis.
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JJ Wetherholt 2B | STL
Cardinals' JJ Wetherholt: Batting leadoff in MLB debut
Wetherholt will start at second base and bat leadoff in Thursday's opener versus the Rays.
The Cardinals will not ease Wetherholt into his major-league debut, putting him atop their batting order. The team's other potential option in the leadoff spot, Masyn Winn, will hit cleanup. Wetherholt earned a spot on St. Louis' Opening Day roster by collecting a .386 on-base percentage with two home runs and two stolen bases during Grapefruit League action.