Machado is not in the lineup for Wednesday's game in Pittsburgh.

Machado will receive his first day off of the season after slashing .206/.400/.353 with one home run and an 11:11 BB:K over his first 45 plate appearances. The Padres will roll with Miguel Andujar at third base in Wednesday's rubber match.

Pasquantino went 0-for-3 with a walk in Tuesday's loss to the Guardians.

Pasquantino went hitless, reaching base only once via a walk in the eighth inning, though nothing came of it in a low-scoring loss for the Royals. After hitting three homers in six games for Team Italy in the World Baseball Classic, Pasquantino has gotten off to a slow start to the regular season, slashing .195/.306/.220 through 11 games. While the sample is far too small to raise significant long-term concern, Kansas City could opt to give Pasquantino an off day soon to allow him to reset after starting every game to open the year.

O'Brien allowed an unearned run while striking out two in the 10th inning Tuesday to record his third save of the season in a 7-6 win over the Nationals.

The right-hander couldn't stop the phantom runner from coming around to score on a groundout and a wild pitch, but O'Brien fanned CJ Abrams and Nasim Nunez to lock down the victory. He's now picked up the Cardinals' last three saves and is emerging as the top option in the bullpen, with JoJo Romero and Ryne Stanek in setup roles. Through six appearances this season, O'Brien has a 0.00 ERA, 0.63 WHIP and 7:0 K:BB in 6.1 innings, adding a win and two holds to his ledger.

Liberatore didn't factor into the decision in Tuesday's 7-6 extra-inning win over the Nationals, giving up four runs on nine hits and two walks over five innings. He struck out six.

The southpaw was tagged for homers by James Wood in the third inning and Curtis Mead in the fifth and exited the game with the Cardinals in a 4-2 hole, but the offense bailed him out late. Liberatore tossed 59 of 92 pitches for strikes and has lasted at least five innings in all three of his starts to begin the year, posting a 3.38 ERA, 1.50 WHIP and 10:5 K:BB over 16 frames. He'll look for his first win of 2026 in his next trip to the mound, which lines up to come at home early next week against the Guardians.

Matsui (groin) has turned in two scoreless rehab appearances at Triple-A El Paso, Jeff Sanders of The San Diego Union-Tribune reports.

Matsui got a late start to the season due to a groin strain that caused him to miss the entire Cactus League slate, but he's looked sharp on his rehab assignment thus far. It's unclear what the Padres' target date is for Matsui's activation from the 15-day injured list, but it could come any day now.

Englert (0-1) took the loss Tuesday, giving up four runs (three earned) on seven hits and a walk over 3.2 innings as the Rays were downed 9-2 by the Cubs. He struck out two.

Tampa Bay rolled out a bullpen game after Drew Rasmussen (personal) was a late scratch, with Englert getting the start and lasting 65 pitches (48 strikes). The right-hander won't be available for long-relief duties for a few days as a result, so it wouldn't be a surprise if he were optioned to Triple-A Durham for a fresh arm. Through four appearances this season, Englert has a 9.45 ERA, 1.95 WHIP and 4:1 K:BB over 6.2 innings.

Walters (lat) was charged with two runs on one hit and one walk over an inning of work in his first rehab appearance with Triple-A Columbus on Tuesday.

Walters averaged 94 mph with his four-seamer, which is down 2.4 mph from his average with the Guardians last season prior to lat surgery. The velocity could come back as he further distances himself from the operation, but if it doesn't, the Guardians might opt to keep Walters at Columbus for a while rather than stick him back in the big-league bullpen.

The Phillies will hold Realmuto (foot) out of the starting nine for Wednesday's game in San Francisco, Todd Zolecki of MLB.com reports.

After being struck in the right foot by a foul tip while catching in the bottom of the first inning in Tuesday's 6-0 loss to the Giants, Realmuto was lifted from the game when his turn in the lineup came up in the top of the second. Fortunately for Realmuto, X-rays came back negative, but he'll receive at least one game off while he contends with bruising and soreness to the foot. Rafael Marchan will draw the start behind the dish Wednesday, but with a team off day on tap Thursday, Realmuto could be ready to resume catching in Friday's series opener versus the Diamondbacks.

The Diamondbacks re-signed Ross to a minor-league contract Tuesday.

Ross elected free agency earlier this week after being removed from the Diamondbacks' 40-man roster, but he's now back in the organization on a new deal. The veteran swingman allowed eight runs on seven hits and four walks over 3.2 frames during his brief time with the big club.

Griffin signed a nine-year, $140 million contract extension with the Pirates on Wednesday.

Per Noah Hiles of the Pittsburgh Post-Gazette, the 19-year-old Griffin's deal is the richest in franchise history and includes a $12 million signing bonus and an additional $10 million in salary escalators. The first teenage position player to debut in the majors since Juan Soto achieved the feat in 2018 with the Nationals, Griffin has gone 3-for-17 (.176 average) with two walks and four strikeouts through his first five games with Pittsburgh. With the long-term deal now finalized, Griffin will be under club control through the 2034 season.