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• 49ers' Isaac Guerendo: Has MCL, ankle sprains

  01/07/2025 • By RotoWire

  Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, Matt Barrows of The Athletic reports. The 49ers' 2024 campaign is over, but the team's season finale included yet another RB injury. On only his second carry of Sunday's game, Guerendo had his left leg twisted under him as he was tackled, and he needed a cart to go to the locker room. While Guerendo did avoid a more serious ACL injury, he's still one of four San Francisco running backs who will enter the offseason focusing on rehab, along with Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring). Guerendo, a 2024 fourth-round pick, proved to be effective when given the chance as a rookie, turning 84 carries into 420 yards (5.0 YPC) and four touchdowns and hauling in 15 of 16 targets for 152 yards in 16 appearances.

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• 49ers' Isaac Guerendo: MCL sprain likely, tests upcoming

  01/06/2025 • By RotoWire

  Coach Kyle Shanahan said after Sunday's 47-24 loss to the Cardinals that Guerendo (knee/ankle) likely suffered an MCL sprain and will undergo further testing Monday, Lindsey Pallares of the 49ers' official site reports. Guerendo suffered knee and ankle injuries, with the knee injury likely to be an MCL sprain. The results of Monday's tests should help provide clarity on the recovery timeline for Guerendo. The 49ers' season came to a close with Sunday's defeat in the regular-season finale.

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• 49ers' Isaac Guerendo: Won't return Sunday

  01/05/2025 • By RotoWire

  Guerendo won't return to Sunday's game at Arizona due to knee and ankle injuries. Guerendo had his left leg twisted under him on his second carry of the game, and his teammates quickly motioned to the sideline for assistance. He eventually was carted off the field and ruled out not long after. With Guerendo unavailable, the 49ers will entrust the run game in Patrick Taylor and FB Kyle Juszczyk for the rest of their season finale.

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• 49ers' Isaac Guerendo: RBs to Start

  01/02/2025 • By Jamey Eisenberg

  Guerendo returned in Week 17 against Detroit following a one-game absence with a hamstring injury, and he scored 13.9 PPR points. He's been a factor in the passing game in his past two outings with eight catches for 83 yards on eight targets, and hopefully, Joshua Dobbs keeps him involved through the air with Brock Purdy (elbow) hurt. The Cardinals have allowed three running backs in their past four games to score at least 16.2 PPR points, and I like Guerendo as a No. 2 Fantasy running back in all leagues in this matchup.

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• 49ers' Isaac Guerendo: Another limited session

  12/27/2024 • By RotoWire

  Guerendo (foot/hamstring) practiced in a limited capacity Friday, Nick Wagoner of ESPN.com reports. Guerendo now has managed back-to-back capped sessions to kick off Week 17 prep as he looks to put foot and hamstring injuries further in the rearview mirror. He sat out the 49ers' Week 16 loss at Miami due to the health concerns, and Saturday's practice report may provide a sense of his odds to return to action Monday against the Lions. If he's cleared for that contest, Guerendo likely will slot back in as the 49ers' lead runner over Patrick Taylor.

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