Purdy (left shoulder/toe) isn't in line to play Sunday against the Cardinals, Adam Schefter of ESPN reports.

Purdy sat out the 49ers' Week 2 win at New Orleans due to the combination of a turf toe variant and an AC joint sprain in his left shoulder. While the quarterback was able to log three limited practices this week, coach Kyle Shanahan said Friday that Purdy was "highly unlikely" to play in Week 3, according to Schefter. The 49ers won't post their inactives until about 90 minutes before Sunday's 4:25 p.m. ET kickoff, but Purdy's name is expected to be included when they do. Mac Jones will earn another spot start in Purdy's place while Adrian Martinez handles backup duties.

Burrow, who underwent surgery Friday to address a Grade 3 turf toe injury, is facing a three-month absence, Ian Rapoport of NFL Network reports.

While coach Zac Taylor declined to provide a timeline for Burrow's recovery, a previous report by Ben Baby of ESPN aligns with Rapoport's estimate that the QB will miss a minimum of three months. With that timetable in mind, Burrow could potentially return later this season, but in the meantime Jake Browning will serve as the Bengals' No. 1 signal-caller.

The 49ers are optimistic that Purdy (toe/shoulder) -- who is listed as questionable but not expected to play Sunday against the Cardinals -- could be ready to start the team's Week 4 game versus the Jaguars, Ian Rapoport of NFL Network reports.

Though Purdy is trending toward missing a second straight game this Sunday while he recovers from turf toe as well as an AC joint sprain in his left shoulder, he made notable progress this week, practicing in a limited fashion from Wednesday through Friday. With the 49ers elevating Adrian Martinez from the practice squad Saturday, Purdy could be inactive Sunday, affording Mac Jones another start while Martinez serves as the top backup. Up to this point, Purdy has healed more quickly from his injuries than the 49ers initially anticipated, so if he's able to increase his practice activity during the upcoming week, he could be cleared to take back the starting role from Jones.

The 49ers elevated Martinez from the practice squad to the active roster Saturday.

Martinez served as the backup quarterback to Mac Jones in Week 2. His status is a bit more in question for Week 3 , as Brock Purdy (toe) is officially listed as questionable despite not being expected to start.

The Jets elevated Cook from the practice squad to the active roster Saturday, Eric Allen of the team's official site reports.

Cook has been with the Jets since signing with the team as an undrafted free agent. He's been on the practice squad to begin the season, but will get a chance to back up Tyrod Taylor in Week 3 against the Buccaneers, as Justin Fields (concussion) is sidelined.

McCarthy (ankle) has been ruled out for Sunday's game against the Bengals, but he was without a walking boot in the locker room Friday, the St. Paul Pioneer Press reports. "We're kind of through the initial wave of that, as far as getting the swelling down and all those things," said head coach Kevin O'Connell.

McCarthy suffered a right high-ankle sprain in last week's loss to Atlanta, and reports have him missing 2-to-4 weeks. He won't be placed on injured reserve, according to the Pioneer Press, but the timetable for his return is uncertain. While his walking without a boot on his ankle is an encouraging sign, he could be held out until Week 7 if the team wants to be cautious, with the Vikings playing overseas Weeks 4 (Sept. 28 versus the Steelers in Dublin) and 5 (Oct. 5 versus the Browns in London) before heading into a bye. It's also possible he will play earlier if he's able to return to practice as early as next week.

Jones is on track for another start, with 49ers coach Kyle Shanhan saying Friday that Brock Purdy (toe/shoulder) is "highly unlikely" to start Sunday's game against Arizona, Adam Schefter of ESPN reports.

The Niners list Purdy as questionable, but Shanahan's comments suggest it's only to leave the door open for a backup role. Jones is preparing for another start, after completing 26 of 39 passes for 279 yards and three touchdowns in a 26-21 win over the Saints last week.

Purdy (shoulder/toe) is listed as questionable for Sunday's game against the Cardinals, even though 49ers coach Kyle Shanahan considers the quarterback "highly unlikely" to play, Adam Schefter of ESPN reports.

The 49ers reportedly are thinking about having Purdy available as the No. 2 or 3 quarterback, while Mac Jones is preparing for another start. The fact that Purdy is being listed as questionable for Week 3 suggests that he's on track to return to the lineup soon, especially if he ends up in uniform this Sunday as a backup.

McKee (thumb) is questionable for Sunday's game against the Rams.

McKee remained limited in practice this week. If he's unable to suit up for Sunday's game, Sam Howell will once again serve as the QB2 behind Jalen Hurts.

Mariota will replace Jayden Daniels (knee) as Washington's starting quarterback Sunday against the Raiders, Jonathan Jones of CBSSports.com reports.

Daniel returned to practice Friday as a limited participant, suggesting he may be ready for Week 4 at Atlanta on Sun., Sept. 28. In the meantime, Mariota will try to replicate his level of play from last season, when he completed 34 of 44 passes for 364 yards and four touchdowns, with 92 yards and another TD on the ground. While unlikely to maintain that type of efficiency, Mariota does seem to be a good fit in Kliff Kingsbury's offense, and with enough running ability to offer fantasy value even if his passing stats are merely average.