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Sam Darnold QB | SEA
Seahawks' Sam Darnold: Won't play in Week 2
Coach Mike Macdonald said Darnold (glute) won't play in Sunday's game at Arizona, Curtis Crabtree of Fox 13 Seattle reports.
Darnold lasted just five plays into the Seahawks' Super Bowl defense before leaving last Wednesday's Week 1 matchup with the Patriots due to what was initially described as a hip injury. After a series of updates since then, Darnold is believed to be tending to a "very unique" glute injury that is accompanied by a recovery timetable of four weeks, per Mike Garafolo of NFL Network. For as long as Darnold is sidelined, Drew Lock will direct Seattle's offense.
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Drew Lock QB | SEA
Seahawks' Drew Lock: Will start Week 2
Lock will start Week 2 against the Cardinals with Sam Darnold (glute) unavailable, Curtis Crabtree of Fox 13 in Seattle reports.
Darnold will miss Week 2 as expected, prompting the Seahawks to tab Lock as the starter. Lock was competent in relief of Darnold in the season opener, completing 16 of 22 passes for 187 yards and a touchdown. Importantly, Lock was clean on the turnover front. He will lead the Seahawks for at least the upcoming road game against the Cardinals, which puts him on the radar in superflex and two-quarterback formats.
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Kyler Murray QB | MIN
Vikings' Kyler Murray: Will be limited Wednesday
Coach Kevin O'Connell said Murray (concussion) will be limited at Wednesday's practice, Dane Mizutani of the St. Paul Pioneer Press reports.
Murray lasted 11 offensive snaps before suffering a concussion this past Sunday against the Packers when he was sandwiched between two defenders. Carson Wentz came on in relief of Murray and helped lead the Vikings to a 39-22 victory. O'Connell told Alec Lewis of The Athletic on Monday that Murray would be evaluated day by day as the team prepares for Sunday's road matchup with the Bears, but if the quarterback doesn't make the requisite progress and gain clearance from an independent neurologist, Wentz again will be under center for Minnesota.
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Joe Burrow QB | CIN
Bengals' Joe Burrow: May be dealing with injury
Burrow wasn't involved in the team stretch and didn't make any throws of substance during Wednesday's practice, Kelsey Conway of The Cincinnati Enquirer reports.
Prior to the stretch, Burrow made throws of roughly 15 yards apart along with backup QB Joe Flacco, per Paul Dehner Jr. of The Athletic. Dehner added that head coach Zac Taylor said Monday that some Bengals would be limited in practice this week, but none of those health concerns were major. Burrow is scheduled to speak with the media Wednesday afternoon, while Cincinnati will post its first Week 2 injury report imminently, so clarity on his situation should arrive in the near future.
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Tua Tagovailoa QB | ATL
Falcons' Tua Tagovailoa: Not practicing Wednesday
Coach Kevin Stefanski said Tagovailoa (oblique) won't take part in Wednesday's practice, Marc Raimondi of ESPN.com reports.
Tagovailoa missed the Falcons' Week 1 loss at Pittsburgh due to an oblique strain that he suffered in practice last Thursday. He hasn't practiced in the meantime, but he still will have two more sessions this week to mix into drills and potentially gain clearance to play Sunday against the Panthers. If Tagovailoa isn't able to do so and Michael Penix (knee) remains sidelined, Cooper Rush likely would be the Falcons' starting QB in Week 2.
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Carson Wentz QB | MIN
Vikings' Carson Wentz: To start if Murray unavailable
Wentz "is likely to start" Sunday against the Bears if Kyler Murray does not clear concussion protocol, Dan Graziano of ESPN.com reports.
Wentz was named the backup quarterback last week and led the Vikings to a Week 1 comeback victory over the Packers, so although fellow reserve J.J. McCarthy would also be an option, Wentz appears to be the favorite to get the nod should Murray be unable to go.
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Miller Moss QB | CHI
Miller Moss: Reverts to Chicago's practice squad
Moss reverted to the Bears' practice squad Tuesday, per the NFL's transaction log.
Moss was inactive for the Bears' 59-37 win over the Panthers last Sunday. The quarterback was elevated to the active roster as the emergency third quarterback if Tyson Bagent (back) was unable to fulfill the role due to injury. Bagent ended up recovering enough from his back injury to be listed as the No. 3 quarterback, and Moss was just inactive for the game.
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Sam Darnold QB | SEA
Seahawks' Sam Darnold: Could have four-week timeline
Darnold (glute) is "looking at about a four-week return to play" but could return "a little bit sooner than that," Mike Garafolo of NFL Network reports.
Reports on Darnold's return date have varied, but the latest one indicates he could miss a bit more time than initially anticipated. What's certain is he's dealing with what the Seahawks are calling a "very unique" soft-tissue injury, but one that is expected to lead to a long-term absence. Drew Lock should continue to start at quarterback for however long Darnold remains sidelined.
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Bo Nix QB | DEN
Broncos' Bo Nix: Miserable showing in Week 1 loss
Nix completed 17 of 28 passes for 131 yards with one touchdown and one interception while adding three carries for two yards in the Broncos' 31-10 loss to the Chiefs on Monday night. He also committed three fumbles, losing one and recovering one of the two others that remained with Denver.
Nix's season and night immediately got off on the wrong foot when he threw an ill-advised interception into blanket coverage on the part of rookie cornerback Mansoor Delane (shoulder) on the Broncos' opening drive of 2026, setting up the Chiefs' first touchdown of the night. When Nix wasn't turning the ball over -- he also lost the handle on a late third-quarter sack to give Kansas City possession at the Broncos' 34-yard line -- he was having significant trouble producing any noteworthy gains with his arm, averaging just 4.7 yards per attempt overall. Nix did connect with Evan Engram in the first quarter for a 19-yard scoring strike that answered the Chiefs' first touchdown, but he'll have plenty of room for improvement in a Week 2 home matchup against the Jaguars on Sunday.
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Patrick Mahomes QB | KC
Chiefs' Patrick Mahomes: Three total TDs in season debut
Mahomes completed 15 of 27 passes for 184 yards with two touchdowns and one interception while adding seven rushes for 23 yards and another score in the Chiefs' 31-10 win over the Broncos on Monday night. He also recovered two fumbles.
Making good on his long-standing pledge to be available for Monday night's game following last December's season-ending knee injury, Mahomes endured a cold start from a statistical standpoint while completing only two of his first 10 passes. However, the two-time regular-season MVP capped off Kansas City's first drive of the season with a 15-yard touchdown run that allayed any fears about his health, and which he punctuated with a dive into the end zone. Mahomes also picked up the pace through the air after his ragged start, and he ended up connecting with Rashee Rice (13 yards) and Kenneth Walker (two yards) for his pair of scoring tosses. The one major blemish on the veteran signal-caller's night came when he air-mailed a pass into the middle of the field early in the second half that was picked off by Brandon Jones at the Chiefs' 29-yard line and set up a Denver field goal. Now with a solid victory over a talented division rival under his belt, Mahomes and the Chiefs head into a Week 2 home matchup against the Colts on Sunday night with plenty of momentum.