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Isiah Pacheco RB | DET
Chiefs' Isiah Pacheco: Leads backfield in Week 16 loss
Pacheco carried the ball eight times for 34 yards and caught six of seven targets for 41 yards in Sunday's 26-9 loss to the Titans.
Kareem Hunt saw only three carries on the day, and one of them turned into a two-yard loss for a safety in the second quarter. As a result, Pacheco saw his biggest touch volume since Week 7 and put together season-high numbers as a receiver. The Kansas City offense is in shambles with Patrick Mahomes and Gardner Minshew going down with knee injuries in consecutive weeks, leaving Chris Oladokun as the likely starting QB for what's left of a lost season. With the team already eliminated from playoff contention, the veteran Hunt could be phased out of the offense, with Pacheco and even 2025 seventh-round pick Brashard Smith seeing more work over the final two weeks, including in a Week 17 battle against the Broncos.
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Zavier Scott RB | MIN
Vikings' Zavier Scott: Three touches as Mason goes down
Scott rushed twice for four yards and caught his only target for eight yards in Sunday's 16-13 win over the Giants.
Scott looked poised to work as Minnesota's lead back after both Aaron Jones and Jordan Mason exited due to first-quarter ankle injuries, but Jones returned and handled a workhorse role, finishing with 23 touches to Scott's three. If Jones' injury impacts his availability for Thursday's game against the Lions and Mason remains sidelined, Scott could find himself handling an increased workload.
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Devin Singletary RB | NYG
Giants' Devin Singletary: Gets 11 carries to Tracy's 16
Singletary rushed 11 times for 47 yards and caught his only target for minus-1 yard in Sunday's 16-13 loss to the Vikings.
Singletary played second fiddle to Tyrone Tracy, who turned 16 carries and two targets into 78 scrimmage yards. Despite Tracy working in the lead role, Singletary has notched double-digit touches in six of the past seven games in the Giants' run-heavy offense. Both running backs could find success in Week 17 against the vulnerable Raiders defense.
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Audric Estime RB | NO
Saints' Audric Estime: Eight touches working behind Hill
Estime rushed five times for 19 yards and caught three of four targets for 17 yards in Sunday's 29-6 win over the Jets.
The Saints were missing Alvin Kamara (knee/ankle) and Devin Neal (hamstring, IR), but Taysom Hill stepped up as the top option at running back. Hill paced the team with 12 carries while Estime and Evan Hull each had five. Even if Kamara remains sidelined in Week 17 against the Titans, Estime will likely remain limited to a complementary role.
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Omarion Hampton RB | LAC
Chargers' Omarion Hampton: Significant workload in win
Hampton carried the ball 16 times for 85 yards and a touchdown in the 34-17 win over the Cowboys on Sunday. He also recorded one reception for 10 yards.
Hampton got a significant workload after Kimani Vidal left the contest due to a neck injury. Head coach Jim Harbaugh declined to give an update on the status of Vidal, but if he's out next Sunday, Hampton could see another game with significant volume as the Chargers attempt to limit a fearsome Houston pass rush come Week 17. The rookie has double-digit carries in each of the past three weeks since returning from a long-term ankle injury, but he could see a bump in targets too given Hampton had 17 receptions early in the season before the emergence of Vidal.
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Javonte Williams RB | DAL
Cowboys' Javonte Williams: Bottled up by Bolts
Williams carried the ball nine times for 34 yards and caught two of three targets for nine yards in Sunday's 34-17 loss to the Chargers.
The 43 scrimmage yards represented his second-lowest output of the season, ahead of only the 34 yards he eked out against the Panthers in Week 6. Williams has already put together the best season of his career with 1,147 yards and 10 TDs on the ground and a 35-137-2 line on 49 targets through the air, and he'll look to add to those totals in Week 17 against the Commanders.
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Bucky Irving RB | TB
Buccaneers' Bucky Irving: Eclipses 70-yard mark in loss
Irving rushed 19 times for 71 yards and wasn't targeted in the Buccaneers' 23-20 loss to the Panthers on Sunday.
Irving easily led the Buccaneers' ground attack in rush attempts and rushing yardage, but he had a long run of just 12 yards and didn't draw a single target for the first time all season. While Irving's rushing yardage tally did match his season high, he also saw Sean Tucker vulture another goal-line opportunity that the latter successfully converted into a touchdown. Irving will aim to exploit a vulnerable Dolphins run defense in a Week 17 road matchup next Sunday.
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Breece Hall RB | NYJ
Jets' Breece Hall: Gets 18 touches in Week 16
Hall rushed 16 times for 54 yards and caught two of three targets for nine yards in Sunday's 29-6 loss to the Saints.
Hall has notched at least 14 rushing attempts in 10 of the last 12 games as the most consistent option in the Jets' lackluster offense. He needs 46 rushing yards over the final two games of the regular season to reach 1,000 for the first time in his four-year NFL career. Hall will try to hit that benchmark in Week 17 against the Patriots.
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De'Von Achane RB | MIA
Dolphins' De'Von Achane: Long rushing TD in loss
Achane rushed 15 times for 81 yards and a touchdown and brought in all three targets for nine yards in the Dolphins' 45-21 loss to the Bengals on Sunday.
The highlight of Achane's afternoon came on his 48-yard scoring scamper late in the first quarter, which served as his third-longest run of the season. Achane's touchdown was his eighth on the ground in 2025, with five of those coming within the last six contests. Achane also now has multiple catches in consecutive contests heading into a Week 17 home matchup against the Buccaneers next Sunday.
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Chase Brown RB | CIN
Bengals' Chase Brown: Finds paydirt three times in Miami
Brown carried the ball 12 times for 66 yards and a touchdown and caught all four of his targets for 43 yards and two more scores in Sunday's 45-21 win over the Dolphins.
All three of Brown's trips to the end zone came in the third quarter, making him the first player in the NFL this season with three TDs in the same period. It was the third time in 2025 that the third-year back has scored multiple touchdowns, but he's got only eight TDs in total (four rushing, four receiving) through 15 contests. Brown lines up for another juicy matchup in Week 17 against the Cardinals.