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Dylan Sampson RB | CLE
Browns' Dylan Sampson: Hurts knee, iffy to return
Sampson sustained a knee injury in the first quarter of Sunday's game against the Jaguars and is considered questionable to return, Mary Kay Cabot of The Cleveland Plain Dealer reports.
Sampson didn't receive any touches on offense but returned two kickoffs for 64 yards before exiting the contest. The second-year running back headed to the locker room and will be evaluated further before the Browns decide whether he'll be able to return to the game.
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Nicholas Singleton RB | TEN
Titans' Nicholas Singleton: Inactive for Week 1
Singleton (coach's decision) is inactive for Sunday's game against the Jets.
The rookie fifth-rounder will be a healthy scratch Week 1 while the Titans role with three active running backs in Tony Pollard, Tyjae Spears and Julius Chestnut. Singleton's next opportunity to make his NFL regular-season debut is Week 2 against the Eagles on Sunday, Sept. 20, though he's unlikely to suit up for that contest unless one of Pollard, Spears or Chestnut is sidelined.
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DJ Giddens RB | IND
Colts' DJ Giddens: Healthy inactive for Week 1
Giddens (coach's decision) is inactive for Sunday's game against the Ravens.
Giddens missed a big chunk of training camp and the preseason due to a hamstring injury, and he was passed on the depth chart by rookie Seth McGowan as the RB2 behind workhorse back Jonathan Taylor.
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LeQuint Allen RB | JAC
Jaguars' LeQuint Allen: Suiting up in Week 1
Allen (hip) is active for Sunday's Week 1 matchup against the Browns.
The change-of-pace back carried a questionable tag into Sunday morning after putting in limited sessions Thursday and Friday, but Allen is all set to suit up versus Cleveland. The second-year pro logged a modest 33 touches from scrimmage across 17 regular-season games during his 2025 rookie campaign, and despite Travis Etienne's departure in free agency this offseason, Allen is slated to remain in a reserve role behind the top RB duo of Bhayshul Tuten and Chris Rodriguez to open the season.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Inactive for Week 1
Kamara (knee) is inactive for Sunday's game against the Lions, Nick Underhill of NewOrleans.Football reports.
It was reported earlier Sunday that Kamara was unlikely to suit up for the opener, and he has indeed been ruled out for Week 1, leaving the New Orleans backfield to starter Travis Etienne, fellow reserve Kendre Miller and practice squad call-up CJ Donaldson. Kamara was able to practice fully Friday, which bodes well for his chances of being ready to go for a Week 2 road matchup against the Ravens next Sunday.
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Sean Tucker RB | TB
Buccaneers' Sean Tucker: Inactive Sunday
Tucker (hamstring) is inactive for Sunday's game at Cincinnati, Scott Smith of the Buccaneers' official site reports.
Tucker followed up a DNP on Wednesday due to a hamstring injury with limited sessions both Thursday and Friday before the Buccaneers listed him as doubtful for Week 1 action. Now that Tucker will be in street clothes Sunday, Josh Williams will be the sole active running back behind the team's top duo of Bucky Irving and Kenny Gainwell. Tucker's next chance to suit up is Sunday, Sept. 20 versus the Browns.
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Ty Johnson RB | BUF
Bills' Ty Johnson: No-go Week 1
Johnson (hamstring) is inactive Week 1 against the Texans.
Johnson was able to log only a single limited practice this week, and the 28-year-old back entered Sunday with a "questionable" tag. He'll ultimately sit against Houston, leaving a few more backfield snaps to starter James Cook and backup Ray Davis. Johnson and the Bills have a short week ahead, as they're set to take on the Lions in a Week 2 matchup Thursday night. If Johnson does end up suiting up then, he'll likely return to his role as a passing down specialist and special-teamer, similar to his last few seasons in Buffalo.
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Josh Jacobs RB | GB
Packers' Josh Jacobs: Time on exempt list could equal time served
Jacobs (personal) remains on the Commissioner's Exempt List, but the NFL may count time on the list as time served if it eventually issues a suspension to the running back, Adam Schefter of ESPN reports.
Jacobs made an appearance in court Thursday and pleaded no contest to misdemeanor charges of battery and criminal damage to property in a case stemming from a May domestic violence incident. There still are some moving parts related to the case, so it's unclear when exactly the NFL may issue a suspension, but Jacobs will continue to miss practices and games as long as he's on the Commissioner's Exempt List.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Not expected to play Week 1
Kamara (knee), who is listed as questionable for Sunday's game in Detroit, isn't in line to play in the season opener and is instead slated to make his 2026 debut Week 2 at Baltimore, Nick Underhill of NewOrleans.Football reports.
Kamara departed a joint practice with the Cowboys on Aug. 18 early and was diagnosed with an MCL sprain that was expected to sideline him for one month. While he followed up back-to-back limited sessions to begin Week 1 prep with a full practice Friday, the Saints will exercise caution with the 10th-year pro and allow him another week to get healthier. In Kamara's anticipated absence Sunday, New Orleans will roll with Travis Etienne as its lead runner, with Kendre Miller and practice-squad call-up CJ Donaldson the other candidates for backfield reps.
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Jeremiyah Love RB | ARI
Cardinals' Jeremiyah Love: Expected to make NFL debut Sunday
Love (ankle) remains listed as questionable but is expected to play in Sunday's game at the Chargers, Ian Rapoport of NFL Network reports.
Love initially suffered a high-ankle sprain during preseason Week 1, and after practicing in a limited fashion from Wednesday through Friday, he entered the weekend as questionable to suit up. Josh Weinfuss of ESPN.com reported Friday that Love was trending toward making his debut Sunday, and Rapoport's report indicates that the rookie third overall pick indeed will avoid the Cardinals' list of Week 1 inactives. Such a decision will become known about 90 minutes before a 4:25 p.m. ET kickoff, but considering his lack of activity over the last month, Love may well be eased into his first NFL action while working in tandem with fellow running back Tyler Allgeier.