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Alvin Kamara RB | NO
Saints' Alvin Kamara: Returns to practice
Kamara (knee) is participating in practice Wednesday, Luke Johnson of The New Orleans Times-Picayune reports.
He'll presumably be a limited participant after missing each of the Saints' three practices last week and eventually being ruled out ahead of the team's loss to the Titans. Even so, Kamara's presence on the field to begin Week 11 prep suggests he has a shot to return a game in Philadelphia on Sunday.
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Elijah Mitchell RB | PHI
49ers' Elijah Mitchell: Expected to play Sunday
Mitchell (finger) isn't practicing Wednesday, but 49ers head coach Kyle Shanahan said he expects the running back to play in Sunday's game against Jacksonville, Nick Wagoner of ESPN.com reports.
Shanahan's comments suggest the surgery Mitchell underwent Tuesday to repair a fractured finger went well, with the running back now hoping to avoid missing time with the injury. Theres some chance the finger issue affects his workload, though it's arguably less of a concern for Mitchell than it would be for other running backs, as he's been targeted in the passing game just nine times across 270 snaps in seven games. With JaMycal Hasty (ankle) also missing practice Wednesday, the healthy running backs in San Francisco are Jeff Wilson, Trey Sermon and Trenton Cannon.
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James Robinson RB | NO
Jaguars' James Robinson: Sits out practice Wednesday
Robinson didn't practice Wednesday due to a bruised heel and a knee injury.
While Robinson continues to manage the heel issue that caused him to sit out Week 9, Ian Rapoport of NFL Network suggests that the running back's knee injury is minor and his absence from practice Wednesday was mostly precautionary. That's a notion that would be solidified if Robinson is able to practice in any capacity Thursday. Robinson is coming off a Week 10 outing against the Colts in which he played 39 of the Jaguars' 66 offensive snaps and finished with 12 carries for 57 yards and a score to go with four receptions for 27 yards.
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Nick Chubb RB | HOU
Browns' Nick Chubb: Not a lock for Week 11
Chubb (illness) remains on the reserve/COVID-19 list as of Wednesday, making him uncertain to play in Sunday's game against Detroit, Nate Ulrich of the Akron Beacon Journal reports.
Chubb still has time to return a pair of negative tests on consecutive days to gain clearance from the list before Sunday, but there's at least some chance of D'Ernest Johnson taking on a huge role again Week 11. In addition to the uncertainty of Chubb's status, Kareem Hunt (calf) has already been ruled out from making a return from injured reserve this weekend. Wednesday marks eight days since Chubb initially was placed on the list following a positive test for the virus.
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Patrick Taylor RB | SF
Packers' Patrick Taylor: May not handle backup role Week 11
Packers head coach Matt LaFleur said Wednesday that Taylor will need to be ready for the No. 2 running back role while Aaron Jones (knee) is unavailable, but the coach also suggested the Packers may look at other options for backup duties behind fill-in starter AJ Dillon, Tom Silverstein of the Milwaukee Journal Sentinel reports.
With Jones expected to miss only a week or two, LaFleur likely is referring to a potential practice squad promotion to challenge Taylor, rather than bringing in a free agent from outside the organization. The Packers have Ryquell Armstead and Kerrith Whyte on their practice squad, while Taylor has been active as the No. 3 back ever since Kylin Hill suffered an ACL tear Week 8. The No. 3 role wasn't expected to come with any work outside of garbage time, but Taylor took two carries for seven yards after Jones made an early exit from Sunday's 17-0 win over the Seahawks. With that in mind, Taylor is the most likely candidate to handle No. 2 duties Sunday against Minnesota, though it may not come with many touches behind Dillon.
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Antonio Gibson RB | NE
Football Team's Antonio Gibson: Remains limited at practice
Gibson (shin) was a limited participant at Wednesday's practice, Nicki Jhabvala of The Washington Post reports.
Playing through a shin stress fracture since Week 4, Gibson came out of the team's recent bye and logged his second-high snap share (61 percent) of the season en route to 24 carries for 64 yards and two touchdowns to go with two catches (on two targets) for 14 yards. The efficiency wasn't there, but he outproduced backup running back J.D. McKissic by a wide margin (26 versus six touches). As such, Gibson is the preferred Washington back, even though he'll continue to operate under practice limitations.
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Clyde Edwards-Helaire RB | KC
Chiefs' Clyde Edwards-Helaire: Week 11 status uncertain
Chiefs head coach Andy Reid said Wednesday that the team wants to see how Edwards-Helaire (knee) performs in practice this week before making a decision on whether to activate the running back from injured reserve prior to Sunday's game against the Cowboys, Herbie Teope of The Kansas City Star reports.
Though Edwards-Helaire is clearly trending in the right direction, Reid acknowledges that there's a chance the Chiefs could hold the running back out for another game, with the team's upcoming Week 12 bye in mind. If that ends up being the case, Darrel Williams would continue to head Kansas City's backfield Week 11, with Jerick McKinnon and Derrick Gore available for complementary work.
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Jermar Jefferson RB | MIN
Lions' Jermar Jefferson: Not practicing
Jefferson (ankle) isn't practicing Wednesday, Tim Twentyman of the Lions' official site reports.
Jefferson's absence to begin Week 11 prep was expected after he scored his first NFL touchdown and then suffered an ankle injury during Sunday's 16-16 tie with Pittsburgh. While Jefferson likely will miss this weekend's game in Cleveland, the Lions at least got Jamaal Williams (thigh) back on the practice field Wednesday, suggesting that D'Andre Swift's top backup is trending in the right direction after a two-game absence.
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Latavius Murray RB | BUF
Ravens' Latavius Murray: Resumes practicing
Murray (ankle) will practice Wednesday, Jamison Hensley of ESPN.com reports.
The running back has missed three straight games with an ankle sprain, but his looming return to practice -- as well as the Ravens' decision to waive Le'Veon Bell on Tuesday -- bodes well for Murray's chances of suiting up Sunday against the Bears. If he's able to return to the lineup Week 11, Murray would likely work in a timeshare with Devonta Freeman, with Ty'Son Williams in reserve.
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Cordarrelle Patterson RB | PIT
Falcons' Cordarrelle Patterson: Likely game-time call for TNF
Falcons head coach Arthur Smith said Patterson (ankle) will be a game-time decision for Thursday's matchup with the Patriots, Michael Rothstein of ESPN.com reports.
Patterson sprained his ankle during the first half of Sunday's blowout loss to Dallas and didn't play at all in the second half. While no injury was reported initially, he's now in some danger of missing additional time, potentially opening up a spot for Wayne Gallman to rotate with Mike Davis in the Atlanta backfield. The Falcons might also elect to expand Davis' role rather than getting Gallman heavily involved, but Davis hasn't exactly made the best case to see more work, having averaged just 3.3 yards per carry and 3.5 yards per target this season The Falcons listed Patterson as a limited practice participant both Monday and Tuesday, suggesting he's got a real shot to suit up despite the short week.