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Jamaal Williams RB | NO
Lions' Jamaal Williams: Expected to play Sunday
Williams (hip), who is listed as questionable for Sunday's game against Minnesota, is expected to play, Adam Schefter of ESPN reports.
Williams was a limited practice participant Wednesday through Friday, which should be enough for him to get the green light to play. Meanwhile, top back D'Andre Swift (groin) is also listed as questionable, but he should also avoid the inactive list. Detroit will clarify the statuses of both running backs approximately 90 minutes prior to Sunday's 1 p.m. ET kickoff.
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Ezekiel Elliott RB | LAC
Cowboys' Ezekiel Elliott: Likely suiting up
Elliott (knee), currently listed as questionable, is expected to play in Sunday's matchup against the Giants, Adam Schefter of ESPN reports.
Elliott logged two limited practices to close out the week, creating optimism that he'll be active for Sunday's game. While that still isn't official, all signs seemingly point to Elliott leading the Cowboys' backfield against the Giants. Elliott is coming off of a strong Week 4 performance, during which he posted a season-best 20 rush attempts and 143 rushing yards in a win over Carolina.
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Nyheim Miller-Hines RB | NO
Colts' Nyheim Hines: Cleared for MNF
Hines (shoulder) doesn't carry an injury designation for Monday night's game against the Ravens after being listed as a full practice participant Saturday.
Now that he's cleared for Week 5 action, Hines will continue to work in a change-of-pace role behind Indy's top back Jonathan Taylor. It's an assignment that has led to hit-or-miss fantasy production for Hines out of the gate. In the Colts' Week 4 win over the Dolphins, Hines logged two carries for six yards and two catches for five yards on two targets. Looking ahead, Hines figures to be more involved in games where the team needs to throw more, which keeps the 24-year-old on the PPR radar.
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David Montgomery RB | HOU
Bears' David Montgomery: Lands on IR
Chicago placed Montgomery (knee) on injured reserve Saturday, Larry Mayer of the Bears' official site reports.
Montgomery will be sidelined for at least three games due to the sprained left knee after being placed on IR, with Ian Rapoport of NFL Network relaying that the Bears are eyeing a 3-to-5-week window for the running back's return. Damien Williams is poised to head Chicago's backfield for the time being, with rookie sixth-round pick Khalil Herbert also a candidate to see his role grow in the coming weeks.
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Melvin Gordon RB | BAL
Broncos' Melvin Gordon: Expected to play Sunday
Broncos head coach Vic Fangio expressed confidence Gordon (lower leg) will play Sunday against the Steelers, despite the running back being listed as questionable after practicing in a limited fashion Thursday and Friday, George Stoia III of The Denver Gazette reports.
Official confirmation of Gordon's Week 5 status will arrive prior to the first wave of games Sunday, with the Broncos kicking off at 1 p.m. ET. Assuming he suits up, as expected, Gordon will continue to operate in a backfield timeshare with rookie Javonte Williams.
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Joe Mixon RB | HOU
Bengals' Joe Mixon: Trending toward suiting up Sunday
Mixon (ankle), who is listed as questionable for Sunday's game against the Packers, went through a workout Saturday and is trending toward playing "in some capacity" Week 5, Tom Pelissero of NFL Network reports.
The running back failed to practice Wednesday through Friday, but he evidently looked good enough during Saturday's workout to have a chance to suit up versus Green Bay. If Mixon avoids the inactive list in advance of Sunday's 1 p.m. ET kickoff, it's unclear if he would be in line for his usual workload. With that in mind, if Mixon is limited at all, Samaje Perine and Chris Evans would be in store for added backfield work.
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Jordan Wilkins RB | CLE
Colts' Jordan Wilkins: Misses practice
Wilkins was a non-participant at Friday's practice due to an illness.
Wilkins was a full participant at Thursday's practice, so he presumably began feeling under the weather after that time. More clarity on his status will be gained via Saturday's practice report.
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Eno Benjamin RB | NO
Cardinals' Eno Benjamin: Nursing injury in Week 5
Benjamin is listed as questionable for Sunday's game against the 49ers due to a hamstring injury, Darren Urban of the Cardinals' official site reports.
Benjamin has either been a healthy inactive or has dressed without playing in each of the Cardinals' 20 regular-season games since he was drafted in the seventh round in 2020, but for the first time in his career, he could be at risk of missing a contest for an injury-related reason. He was a limited participant throughout the week due to the hamstring issue.
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Chuba Hubbard RB | CAR
Panthers' Chuba Hubbard: Likely getting another start Week 5
Hubbard is expected to remain the Panthers' starting running back for Sunday's game against the Eagles with top option Christian McCaffrey (hamstring) listed as doubtful for the contest, David Newton of ESPN.com reports.
Though McCaffrey and head coach Matt Rhule consistently expressed optimism throughout the week about the former's recovery from the hamstring injury, McCaffrey looks set to miss his second straight game after he managed only limited participation in practices Wednesday through Friday. Unless McCaffrey exhibits remarkable progress heading into Sunday, he'll yield starting duties to Hubbard, who played 47 percent of the offensive snaps in the Panthers' Week 4 loss to the Cowboys and finished with 71 yards on 15 touches (13 carries, two catches). A negative game script for most of that contest resulted in Hubbard losing some passing-down work to Rodney Smith, but the rookie could be in better position to deliver a more useful fantasy line Week 5. Not only are the Panthers home favorites in the contest, but Hubbard will also be facing off against the NFL's 31st-ranked run defense.