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Boston Scott RB | PIT
Eagles' Boston Scott: Set for major workload
Scott is expected to see a major uptick in snaps after Miles Sanders (hamstring) was ruled out ahead of Sunday's game, Adam Schefter of ESPN reports.
The last time Scott sat atop Philadelphia's depth chart, the 25-year-old recorded 23 total touches, 138 total yards and three touchdowns in last year's Week 16 win over the Giants. While Scott will at least have Corey Clement and Jason Huntley to split some snaps with this time, it's entirely possible the backup could see a similar workload with Sanders set to miss Sunday's game. Washington's front four could pose some problems for Scott on between-the-tackles runs, but his ability to be a difference maker out of the backfield could make for a trendy play in PPR formats.
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Miles Sanders RB | DAL
Eagles' Miles Sanders: Ruled out Sunday
Sanders (hamstring) will not make the trip to Washington and is out for Sunday's game, Adam Schefter of ESPN reports.
Sanders missed much of the later stages of training camp due to a hamstring injury, and after being called "day-to-day" Wednesday by coach Doug Pederson, the running back proceeded to log three consecutive limited practices. However, the Eagles have decided to play it safe and hold him out this week. Pederson will turn to some combination of Boston Scott, Corey Clement (quadriceps) and Jason Huntley to pick up the slack in the Philly backfield.
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Darrynton Evans RB | BUF
Titans' Darrynton Evans: Not playing Monday
Evans (hamstring) will not play Monday against the Broncos, Jim Wyatt of the Titans' official site reports.
Evans was a limited participant in practice all week but the Titans evidently didn't feel comfortable with Evans as the primary backup to Derrick Henry. Senorise Perry will act in the capacity Monday, although it's possible the Titans could also bring up a running back from the practice squad to provide depth. The team has until Monday to make that roster decision.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Locks in massive extension
Kamara signed a five-year, $75 million extension Saturday which includes just over $34 million in guarantees, Ian Rapoport of NFL Network reports.
The move comes only moments after Vikings running back Dalvin Cook reportedly agreed to a five-year extension in the range of $62 million. It's a massive windfall for Kamara given the running back market in past seasons, though with a number of major backs already locked into new deals, it makes sense that the Saints were so aggressive in re-signing their star running back. Kamara missed multiple practices during the latter stages of training camp with a minor back issue, one which was reportedly perceived as a holdout of sorts, but that was quickly denied by the running back, according to Mike Triplett of ESPN.com. Expect the newly minted $75 million man to be a major fantasy asset Week 1 in a major divisional tilt against the Buccaneers.
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Dalvin Cook RB | DAL
Vikings' Dalvin Cook: Inks five-year extension
Cook came to terms Saturday with the Vikings on a five-year, $63 million contract extension, which includes $28 million guaranteed, Tom Pelissero of NFL Network reports.
With Cook signed to an extension, there's no longer any risk that he'll hold out this season. Cook now looks set to be the main running back in the Minnesota backfield for this season and beyond. With his contract situation resolved, Cook will turn his focus to the Vikings' season-opening matchup with Green Bay on Sunday. He had a career-high 154 rushing yards in his lone outing against the Packers in 2019, breaking free for a 75-yard touchdown in the Week 2 loss.
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Jerick McKinnon RB | KC
49ers' Jerick McKinnon: Could see elevated role Week 1
McKinnon could be in line for primary backup duties behind Raheem Mostert if Tevin Coleman (health concern) is held out due to poor air conditions against the Cardinals on Sunday.
Coleman has sickle cell trait, which puts him at increased risk for contracting breathing problems in unhealthy air conditions like the current one in Santa Clara. The air quality index (AQI) sat between 150-200 Friday at Levi's Stadium, which is extremely poor for even a healthy human. Assuming the game doesn't get postponed, McKinnon would stand to benefit the most if Coleman is held out of the contest. Head coach Kyle Shanahan routinely uses a tandem backfield approach, so whichever player backs up Raheem Mostert should see touches in the low double-digits. McKinnon hasn't logged an official snap since signing a big free-agent contract with San Francisco in 2018, but the 28-year-old could flourish in Shanahan's zone-run scheme that utilizes speedy backs who can catch. Expect a final decision on Coleman's status between now and kickoff Sunday.
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Darwin Thompson RB | LV
Chiefs' Darwin Thompson: Limited to special teams
Thompson did not take the field on offense during the opener versus the Texans.
A sixth-round pick by the Chiefs last season, Thompson managed to hold on to a roster spot behind Clyde Edwards-Helaire and Darrel Williams possibly due, in part, to his familiarity with the playbook. Regardless, he seems to be the clear No. 3 in the rotation and will presumably be limited to special teams as long as the other two are healthy.
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Darrel Williams RB | NO
Chiefs' Darrel Williams: Nine touches in opener
Williams logged seven carries for 23 yards and hauled in two passes for seven yards on two targets in the opener versus the Texans on Thursday.
While Williams was a clear No. 2 behind Clyde Edwards-Helaire, no other running back even aw the field in the opener. This likely points to Williams taking over the lead role should Edwards-Helaire miss time, but he may not see enough action on a weekly basis to justify usage under normal circumstances.
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La'Mical Perine RB | PIT
Jets' La'Mical Perine: Won't make debut versus Bills
Perine (ankle) is ruled out for Sunday's divisional tilt against Buffalo, Rich Cimini of ESPN.com reports.
Perine has yet to resume practicing since suffering a low-ankle sprain during the last week of training camp, so he may not yet be close to a return. That the Jets haven't placed Perine on injured reserve for a minimum of three weeks seems to indicate that the rookie will retake the field at some point this month, but even when healthy he's unlikely to handle significant carries behind Le'Veon Bell and Frank Gore.