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Dameon Pierce RB | PHI
Eagles' Dameon Pierce: Elevated to 53-man roster
The Eagles elevated Pierce from the practice squad to the 53-man roster Wednesday, Jeremy Fowler of ESPN.com reports.
With the Eagles' practice week kicking off Wednesday, Pierce is getting the nod over Jaydon Blue, as Saquon Barkley deals with a hamstring injury that he suffered in last Sunday's loss to the Rams. Tank Bigsby (abdomen) was placed on injured reserve Tuesday, so there's a real chance Philly's backfield consists of Will Shipley and Pierce against the Jaguars in London on Sunday. Shipley is the hot addition off the waiver wire in fantasy this week, but it's no guarantee that he handles the majority of the rushing work ahead of Pierce, who is a prototypical early-down rusher. Shipley has been the team's preferred passing-down back this season. Pierce is certainly worth a speculative add in most fantasy formats.
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Cash Jones RB | ATL
Cash Jones: Cut loose by Atlanta
The Falcons cut Jones from the practice squad Tuesday, Aaron Wilson of KPRC 2 Houston reports.
Jones stuck around with the Falcons on the practice squad after failing to make the team's 53-man roster at the end of training camp. The undrafted rookie is now a free agent, and he should garner some interest from teams looking to add depth to the backfield.
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Kendre Miller RB | NO
Saints' Kendre Miller: Six carries in defeat
Miller rushed six time for nine yards and caught two of three targets while losing a fumble in Monday night's 45-24 loss to Atlanta.
Miller was rumored to be on track for a larger workload in Week 4 after starting running back Travis Etienne (hamstring) was placed on injured reserve. Miller was only on the field for 26 percent of the team's offensive snaps, which could have been as a result of a first-quarter fumble that Atlanta ultimately recovered. Veteran Alvin Kamara was on the field for 41 percent of the offensive snaps, turning seven carries into 23 yards and two scores while also reeling in five of seven targets for 35 yards in the contest. It appears as if Miller will operate as the No. 2 option behind Kamara in Etienne's absence, making him a low-upside fantasy option.
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CJ Donaldson RB | NO
Saints' CJ Donaldson: Sees extra work in garbage time
Donaldson logged three carries for 18 yards and caught both of his targets for five yards during the Saints' 45-24 loss to the Falcons on Monday. He also added a tackle on special teams.
All of Donaldson's offensive production came on the Saints' final drive of the contest, when the game was already well out of reach. His 28 offensive snaps ended up being tied with Alvin Kamara for most among Saints running backs, with Kendre Miller (19) not far behind. Donaldson was more efficient with his touches than both Kamara and Miller, but for as much as the Saints' run game struggled in the absence of Travis Etienne (hamstring), it's hard to envision Donaldson as the lead back in New Orleans for the foreseeable future. That said, if Donaldson is trusted by head coach Kellen Moore as a backfield blocker on pass protection, then he could operate in an elevated role in Week 5 against the Vikings and their blitz-happy defense under defensive coordinator Brian Flores.
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Jam Miller RB | ATL
Jam Miller: Joins Atlanta's practice squad
Miller was signed to the Falcons' practice squad Tuesday, Matt Zenitz of CBSSports.com reports.
Miller worked out with Atlanta on Sept. 29, and he will now join the team's practice unit. The Patriots drafted the running back in the seventh round of the 2026 NFL Draft, but he waived by the team after reaching an injury settlement following an undisclosed injury in late August. Miller spent his entire four-year collegiate career at Alabama, and he'll look to earn an elevation to the active roster down the road this season.
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Anthony Tyus III RB | CAR
Anthony Tyus: Cut loose by Carolina
The Panthers waived Tyus on Tuesday, Darin Gantt of the team's official site reports.
Tyus was signed to the Panthers' active roster Sept. 30, but he's now off the 53-man roster as the team anticipates the return of Trevor Ettiene (ankle) from injured reserve following the Week 5 bye. Assuming he clears waivers, Tyus will explore his next options and should garner interest from teams looking for backfield depth and a returner on kickoffs.
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Damon Bankston RB | GB
Damon Bankston: Back with Packers' practice squad
Bankston was signed to the Packers' practice squad Tuesday.
Bankston will return to the practice squad with Green Bay after being released by the team Sept. 29. The running back has yet to be elevated to the active roster for a contest this season, and he could get his chance Week 5 against the Bears if Chris Brooks (ankle) is unavailable.
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Dontae McMillan RB | BAL
Dontae McMillan: Signed to Seattle's practice squad
McMillan was signed to the Seahawks' practice squad Tuesday.
McMillan will replace fellow running back Jacardia Wright (foot) on the team's practice squad following Wright's placement on the practice squad injured list Tuesday. The team decided to sign McMillan over veteran Joe Mixon (foot) after Mixon failed a physical.
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Tank Bigsby RB | PHI
Eagles' Tank Bigsby: Placed on IR
The Eagles placed Bigsby (abdomen) on injured reserve Tuesday, Zach Berman of The Athletic reports.
Bigsby will require core muscle surgery for an abdominal injury that he picked up during the Eagles' Week 4 loss to the Rams. The fourth-year pro will be required to miss at least the next four games, so the earliest he can return is Week 9 against the Giants on Sunday, Nov. 8. Saquon Barkley (hamstring) is considered week-to-week, and with Bigsby on IR, Will Shipley could be the Eagles' starting running back for Week 5 against the Jaguars on Sunday in London.
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Jacardia Wright RB | SEA
Jacardia Wright: Placed on injured list
The Seahawks placed Wright (foot) on the practice squad injured list Tuesday.
Wright was the only remaining running back on Seattle's practice squad, per Brady Henderson of ESPN.com. The 26-year-old is ineligible to be elevated to the active roster for the next four games, adding to an already injured running back group, with Zach Charbonnet (Knee - ACL) and Jadarian Price (chest) both on injured reserve.