Ravens coach John Harbaugh said Wednesday that Mitchell "has a chance" to play Sunday versus the Texans, Cordell Woodland of 105.7 The Fan Baltimore reports.

Mitchell has been a healthy scratch for each of Baltimore's first four regular-season games, but with Lamar Jackson (hamstring) expected to sit out Week 5 against Houston, the team could deploy a different backfield approach. If active Sunday, Mitchell will be in position to compete for complementary snaps behind Derrick Henry and Justice Hill on offense, as well as with Rasheen Ali on special teams.

Jefferson signed with the Cardinals' practice squad Wednesday.

With both James Conner (foot) and Trey Benson (knee) being placed on injured reserve, Jefferson's signing provides a depth option at running back. He last played for the Lions in 2024, taking six carries for 22 yards over 12 offensive snaps. Jefferson could be elevated to the Cardinals' active roster as soon as the Week 5 matchup against the Titans.

The Cardinals officially placed Benson (knee) on injured reserve Wednesday.

Arizona has lost its top two running backs in back-to-back weeks -- first James Conner to season-ending foot surgery following Week 3 and now Benson to a knee injury for at least the next four games after Week 4. Adam Schefter of ESPN reported earlier Wednesday that Benson underwent arthroscopic surgery for a meniscus injury and was slated to be out 4-to-6 weeks, so even if he isn't able to return from IR when first eligible Sunday, Nov. 9 in Seattle, he should be back in the fold not long after that. For the foreseeable future, Emari Demercado and Michael Carter line up as the best bets to pace the Cardinals backfield, while Bam Knight also is on the active roster and D'Ernest Johnson and Jermar Jefferson are candidates to be elevated from the practice squad.

Spears (ankle) was designated to return from injured reserve Wednesday, Jim Wyatt of the Titans' official site reports.

The designation opens up a three-week window for Spears, who remains on IR, to practice with the team. In the meantime, he won't count against the team's 53-man roster, but barring any setbacks, Spears -- who is eligible to return to practice Wednesday -- is moving toward bolstering the Titans backfield, which has been led by Tony Pollard through the first four weeks of the season.

Benson underwent arthroscopic surgery for a meniscus injury and will be placed on injured reserve, keeping him sidelined for 4-to-6 weeks, Adam Schefter of ESPN reports.

Earlier Wednesday, Schefter reported that Benson banged his knee near the end of last Thursday's loss to the Seahawks, and coach Jonathan Gannon followed up that report with news that the running back was heading to injured reserve but that he should return at some point this season, per Dani Sureck of the Cardinals' official site. Now that a timetable for Benson to recover has been outlined, he'll still miss at least the next four games while on IR, meaning his first chance for game action will be Sunday, Nov. 9 at Seattle. In the meantime, the Cardinals will roll with Emari Demercado and Michael Carter out of the backfield.

Demercado is slated for expanded backfield opportunities, beginning Sunday versus the Titans, with Trey Benson (knee) in line to be placed on IR, Darren Urban of the Cardinals' official site reports.

Demercado looked solid in a change-of-pace role behind Benson during last Thursday's 23-20 loss to Seattle, in which he rushed twice for eight yards and secured both of his targets for 13 yards and a touchdown. With Benson now out at 4-to-6 weeks, per Adam Schefter of ESPN, and James Conner (foot) already lost for the season, Demercado and Michael Carter now become positioned to lead Arizona's backfield, while Bam Knight steps into the No. 3 role. It's possible that Demercado still primarily operates as a pass-catching specialist, but at 215 pounds he's more suitable than the 201-pound Carter for between-the-tackles work. Especially in PPR formats, this development places Demercado firmly on the fantasy radar, though the Cardinals now become strong candidates to pursue further backfield additions.

Gaskin signed with the Seahawks' practice squad Wednesday, Adam Schefter of ESPN reports.

Gaskin was cut by the Ravens in late August after failing to make the team's initial 53-man roster, but he's since found a new home in Seattle. The Washington product last played for the Vikings in 2024, logging 31 total snaps (six offensive, 25 on special teams) while touching the ball four times for 10 yards.

Tracy (shoulder) is not practicing Wednesday, Dan Duggan of The Athletic reports.

Tracy's shoulder injury forced him to sit out Week 4, and reports suggest that he'll be sidelined multiple games. With all expectations being that Tracy again sits out Week 5, Devin Singletary will get another opportunity to contribute as the No. 2 running back behind rookie Cam Skattebo. After that, Tracy will face a short turnaround to attempt to take the field on Thursday Night Football against the Eagles in Week 6.

Cardinals head coach Jonathan Gannon said Wednesday that Benson (knee) will be placed on IR, Dani Sureck of the Cardinals' official site reports.

Gannon said Benson is expected to return this season, but the second-year pro will now be forced to sit out at least four games while recovering from the knee injury he sustained Week 4 versus Seattle. Benson's loss is a tremendous blow for Arizona's offense, one magnified by already having lost James Conner (foot) for the year. Beginning Sunday versus the Titans, and through at least Sunday, Nov. 9 against the Cowboys, Emari Demercado and Michael Carter will be positioned to lead the Cardinals' backfield, with Bam Knight mixing in as the No. 3 option.

Tyus signed with the Panthers' practice squad Wednesday, Darin Gantt of the team's official site reports.

The Ohio product was dropped from Seattle's practice squad in late August but has now found a new home in Carolina. Tyus has yet to appear in an NFL game after rushing 237 times for 1,215 yards and nine touchdowns during his final collegiate season in 2024.