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Derrick Henry RB | BAL
Titans' Derrick Henry: Held to season lows
Henry ran for seven yards on six carries in Sunday's 57-14 loss to Houston.
Tennessee's goal each week is to play smash-mouth football with Henry, DeMarco Murray and Marcus Mariota. That said, the offense couldn't remain that way down multiple scores in the second quarter Sunday. Henry has divided touches fairly evenly with Murray thus far this season (48 to 40 in favor of Murray). Expect them both to get more work if Matt Cassel is forced into a few starts in place of Mariota, who is dealing with a hamstring injury.
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D'Onta Foreman RB | CLE
Texans' D'Onta Foreman: Runs for 45 yards
Foreman rushed for 45 yards on 13 carries in Sunday's 57-14 win over Tennessee.
The performance was the best yet for the rookie back, but it was likely a product of Houston's healthy lead. Nine of Foreman's carries came in the third quarter with the Texans up multiple scores. A big power back, Foreman is an excellent complement for the speedy Lamar Miller, and he's made a few big plays himself thus far this season. However, don't expect him to top more than 10 or 12 touches on a week-to-week basis.
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Dalvin Cook RB | DAL
Vikings' Dalvin Cook: MRI on tap
Cook (left knee) needed crutches to leave the locker room after Sunday's 14-7 loss to the Lions, Tom Pelissero of NFL.com reports. "We're concerned about his ACL, but he's going to get a MRI in the morning," head coach Mike Zimmer said.
Cook went down early in the third quarter with a non-contact knee injury, which typically indicates ligament damage of some type. Clearly, a tear of his ACL would be accompanied by a lengthy absence, but Monday's examination will impart the severity of the ailment. If he requires time away from the field, Latavius Murray (seven carries for 21 yards and two receptions for eight yards Sunday) and Jerick McKinnon (no yards on two rushes) would combine to keep the Vikings' ground game afloat.
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Mike Gillislee RB | NE
Patriots' Mike Gillislee: Logs 12 carries Sunday
Gillislee carried 12 times for 49 yards in Sunday's 33-30 loss to the Panthers.
After scoring three TDs in Week 1 and one in Week 2, Gillislee has logged back-to-back 12-carry efforts without finding the end zone. He's not much of a factor in the Patriots' passing game, so he'll head into Week 5's contest against the Buccaneers on Thursday as a TD-dependent fantasy option.
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Dalvin Cook RB | DAL
Vikings' Dalvin Cook: Sustains left knee injury
Cook has been ruled out of Sunday's game against the Lions due to a knee injury.
On the first play of the Vikings' second possession after halftime, Cook galloped for 10 yards before going down with a non-contact injury to his left knee, per Courtney Cronin of ESPN.com. Cook immediately grabbed at his knee but was able to walk to the locker room under his own power. While the Vikings will surely touch on Cook's health in the aftermath of the game, Jerick McKinnon and Latavius Murray will head the backfield Sunday and perhaps beyond.
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Melvin Gordon RB | BAL
Chargers' Melvin Gordon: In uniform Sunday
Gordon (knee) is listed as active for Sunday's game against the Eagles.
Gordon, who the Chargers listed as a full practice participant Friday, will suit up Sunday, as expected. In the process, he'll take aim at an Eagles defense that has held opponents to an average of 75 rushing yards per game to date.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Force in passing game Sunday
Kamara rushed five times for 25 yards and brought in all 10 of his targets for 71 yards and a touchdown in Sunday's 20-0 win over the Dolphins in London. He also totaled 23 yards on his sole kickoff return.
After a trio of serviceable performances to start his career, Kamara's Week 4 tally could be considered a breakout effort, considering his reception total paced the Saints. The 22-year-old rookie was a trusted outlet option for QB Drew Brees throughout the afternoon and then capped off the scoring on the day with a 12-yard touchdown reception late in the fourth quarter. Kamara's usage in the passing game is naturally an encouraging development for fantasy owners, one that he'll look to uphold when the Saints take on the Lions in Week 6 following a Week 5 bye.
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Cameron Artis-Payne RB | CAR
Panthers' Cameron Artis-Payne: Available in Week 4
Artis-Payne is listed as active Sunday in New England, Joe Person of The Charlotte Observer reports.
Artis-Payne will be available on game day for the first time this season. With all four running backs on the 53-man roster active, though, it remains to be seen exactly how he'll be utilized. More than likely, Artis-Payne is slated for special-teams duty.
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Melvin Gordon RB | BAL
Chargers' Melvin Gordon: Expected to play Sunday
Gordon (knee) will play Sunday against the Eagles, a source told Adam Schefter of ESPN.
Gordon was able to practice fully Friday and head coach Anthony Lynn said he expected him to play. Still, this report would seem to remove any questions if he'll be ready for Sunday's game.
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Rob Kelley RB | NO
Redskins' Rob Kelley: Listed as questionable
The Redskins have officially listed Kelley (ribs) as questionable for Monday night's game against the Chiefs, John Keim of ESPN reports.
Kelley, who has been limited at practice since a suffering a rib cartilage injury Week 2 against the Rams, appears on track to be a true game-time decision Monday night. Should the 24-year-old ultimately be ruled out for a second straight week, Samaje Perine would presumably remain the team's primary early-down runner in his place, while Chris Thompson would continue getting reps in passing situations.