McLaughlin (coach's decision) is inactive for Sunday's game against the Titans, Aric DiLalla of the Broncos' official site reports.

The Broncos will go with a three-man backfield of J.K. Dobbins, RJ Harvey and Tyler Badie, which means McLaughlin will observe Sunday's regular-season opener in street clothes. McLaughlin's next opportunity to play is Week 2 against the Colts on Sunday, Sept. 14, though he's unlikely to see any playing time -- if any -- unless there's an injury in the Broncos' backfield.

McCaffrey (calf) is active for Sunday's game against the Seahawks.

McCaffrey's status heading into Week 1 was cloudy after he was limited in Thursday's practice due to the calf issue before sitting out Friday's session entirely. However, after Ian Rapoport of NFL Network reported that McCaffrey was a "big participant' in Saturday's team walk-through, the 49ers were apparently satisfied enough with the star tailback's condition to clear him for the season opener. Though McCaffrey looks poised to handle his usual lead role out of the backfield, the 49ers could still aim to ease him with a lighter workload than initially planned if the team still has any lingering concern about the health of his calf.

Nwangwu (hamstring) is questionable to return to Sunday's game against the Steelers.

Nwangwu picked up the injury in the first quarter and is being evaluated by trainers to determine the severity of the injury. Arian Smith would figure to join Xavier Gipson on kick returns if Nwangwu is unable to return.

The Texans envision Chubb serving as their "bell-cow running back" in Sunday's season opener versus the Rams, Ian Rapoport of NFL Network reports.

Joe Mixon (foot/ankle) racked up 12 touchdowns and 1,325 yards in 12 games as the Texans' lead back in 2024, but he'll miss at least the first four contests of 2025 after being placed on the reserve/non-football injury list Aug. 26. With Mixon out of the picture for at least the first quarter of the season, Chubb looks poised to have an extended runway to lead the Houston backfield. Chubb's final season in Cleveland was cut short by a foot fracture that he sustained Dec. 15, but he avoided surgery and has reportedly looked healthy and effective in training camp after joining Houston on a one-year deal in June. When available, Chubb has proven to be one of the NFL's most efficient runners, though he averaged a career-worst 3.3 yards per carry over his eight games in Cleveland a season ago. He could be in line for some improvement now that he's further removed from the major knee surgery he required in September 2023, and while he looks poised to dominate the early-down work out of the Houston backfield, Chubb has never been a major contributor in the passing game and could cede most of those reps to Dameon Pierce, Woody Marks or Dare Ogunbowale.

Knight (coach's decision) is inactive for Sunday's game against the Saints, Darren Urban of the Cardinals' official site reports.

Knight will not suit up Week 1, as the Cardinals will roll with a three-man backfield of James Conner, Trey Benson and Emari Demercado. Knight has not played in a regular-season game since 2023 with the Lions, and his next opportunity to see the field is Week 2 against the Panthers on Sunday, Sept. 14.

Carter is inactive for Sunday's regular-season opener against Tampa Bay, Tori McElhaney of the Falcons' official site reports.

Carter made Atlanta's initial 53-man roster following a strong preseason, but he's not expected to see much work on offense this season with Bijan Robinson and Tyler Allgeier heading the Falcons' backfield. Carlos Washington, who was elevated from the practice squad Saturday, will serve as the team's third RB in Week 1.

Rodriguez (coach's decision) is inactive for Sunday's game against the Giants.

Rodriguez thus is the odd man out in a Commanders backfield that will be playing without Brian Robinson following his trade to the 49ers on Aug. 22. Instead, some combination of Austin Ekeler, rookie seventh-round pick Jacory Croskey-Merritt and Jeremy McNichols will be Washington's available running backs Sunday. Rodriguez's next chance to suit up will be Thursday at Green Bay.

Mostert (coach's decision) is a healthy inactive for Sunday's game against New England.

Mostert's inactive status comes as a surprise, as he's not known to be dealing with an injury and was listed as the Raiders' RB2 or RB3 on the team's initial Week 1 depth chart, per Vincent Bonsignore of the Las Vegas Review-Journal. With Mostert out of action, Las Vegas will go with Zamir White and Dylan Laube as the active running backs behind rookie starter Ashton Jeanty.

Goodson (elbow) is inactive for Sunday's season opener against the Dolphins.

After being limited at practice this week, Goodson approached the contest listed as questionable. With his regular-season debut on hold, DJ Giddens and Ulysses Bentley are available Sunday to handle backfield snaps that don't go to Jonathan Taylor. Goodson's next chance to see action will occur next weekend against the Broncos.

Williams (coach's decision) is inactive for Sunday's game against the Falcons.

Williams managed to crack the Buccaneers' 53-man roster after a strong training camp, but the undrafted rookie out of LSU will be in street clothes for Week 1 as Tampa Bay goes with a three-man backfield of Bucky Irving, Rachaad White and Sean Tucker. Williams' next chance to make his NFL regular-season debut is Week 2 against the Texans on Monday, Sept. 15.