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Saquon Barkley RB | PHI
Eagles' Saquon Barkley: Injures hamstring in Week 4
Barkley suffered a hamstring injury during Sunday's game against the Rams, Olivia Reiner of the Philadelphia Inquirer reports.
Barkley walked slowly to the sideline after a six-yard run in the first quarter and visited the medical tent before making his way to the locker room. During Barkley's absence, Tank Bigsby and Will Shipley are the candidates for reps out of the Eagles backfield.
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Saquon Barkley RB | PHI
Eagles' Saquon Barkley: Enters medical tent in first quarter
Barkley (lower body) made his way to the sideline slowly and then entered the medical tent during the first quarter of Sunday's game against the Rams, Olivia Reiner of the Philadelphia Inquirer reports.
After a six-yard run on the Eagles' second possession, the aforementioned situation befell Barkley. For as long as Barkley is sidelined, Tank Bigsby and Will Shipley will man Philadelphia's backfield.
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Joe Mixon RB | HOU
Joe Mixon: Meeting on tap with Seattle
Mixon (foot) is set to visit with the Seahawks during the upcoming week, Jay Glazer of Fox Sports reports.
After missing the entire 2025 season due to a foot injury and then being released by Houston in March, Mixon looked like he might have been headed for retirement. However, the 30-year-old Mixon seems to have made enough progress in his recovery over the last few months to entertain a return to the NFL, and the running back-needy Seahawks will bring him in for a look. Even if he ends up signing with Seattle, Mixon could need some time to get back up to full speed after having not played or practiced with a team since 2024.
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Reggie Gilliam RB | NE
Patriots' Reggie Gilliam: Good to go against Buffalo
Gilliam (knee) is active against the Bills on Sunday.
The veteran fullback has been working through a knee injury, but he's been cleared by medical staff to play after going through pregame warmups. Gilliam spent the first six years of his NFL career with the Bills before signing a three-year contract with the Patriots in March.
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Michael Carter RB | TEN
Titans' Michael Carter: Healthy scratch Week 4
Carter (coach's decision) is inactive for Sunday's tilt against the Ravens.
Carter was elevated from the practice squad for last Sunday's game against the Giants but ended up being a healthy scratch. The veteran running back then signed to the Titans' 53-man roster Tuesday, yet he's inactive on game day for a second straight week. It appears Carter is essentially insurance in case one of the four running backs ahead of him in the pecking order becomes unavailable.
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Ray Davis RB | BUF
Bills' Ray Davis: Active in Week 4
Davis (hamstring) is expected to play against the Patriots on Sunday.
Davis was questionable heading into Sunday's game after participating as a limited participant in Friday's practice. The 26-year-old has one rushing attempt through three regular-season games for three yards.
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Devin Singletary RB | NYG
Giants' Devin Singletary: Healthy scratch again
Singletary (coach's decision) is inactive for Sunday's game against the Cardinals, Dan Salomone of the Giants' official site reports.
Singletary will be a healthy scratch for a second consecutive week while the Giants roll with Tyrone Tracy and Najee Harris as the backup options in the backfield behind Cam Skattebo. Singletary's next opportunity to suit up is Week 5 against the Commanders on Sunday, Oct. 11.
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Emari Demercado RB | DAL
Cowboys' Emari Demercado: Won't play against Houston
Demercado (coach's decision) is inactive for Sunday's game against the Texans, Joe Hoyt of The Dallas Morning News reports.
Demercado will be a healthy scratch for a second consecutive week, which leaves Tyler Goodson as the lone backup option to Javonte Williams. Demercado's next chance to play is Thursday against the Buccaneers, although he doesn't have a clear path to playing time unless one or both of Williams and Goodson were to miss time.
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Tyjae Spears RB | TEN
Titans' Tyjae Spears: Good to go Sunday
Spears (ankle) is active for Sunday's game against the Ravens.
While managing the ankle injury, Spears managed just one full practice this week and took a questionable tag into Sunday, but he looks like he'll be available to handle his usual No. 2 role behind Tony Pollard. Through Tennessee's first three games, Spears has carried 13 times for 58 yards (4.5 YPC) to go with four receptions for 41 yards on six targets.
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Tyjae Spears RB | TEN
Titans' Tyjae Spears: In line to play in Week 4
Spears (ankle), who is listed as questionable for Sunday's game at Baltimore, is slated to play, Ian Rapoport of NFL Network reports.
Spears was able to play through his ankle injury last Sunday at the Giants, and while he earned a 47 percent snap share, he mustered just three carries for five yards and wasn't targeted in the passing game. Fellow RB Tony Pollard handled the other 53 percent and turned his 21 touches into 96 yards from scrimmage. Considering Spears progressed from DNP on Wednesday to limited Thursday and full Friday, he appears set to serve in a similar role alongside Pollard on Sunday, assuming the former is active.