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Rasheen Ali RB | BAL
Ravens' Rasheen Ali: Not returning Sunday
Ali (concussion) is out for the rest of Sunday's game against the Browns, Brian Wacker of The Baltimore Sun reports.
The running back and special-teams asset was evaluated for a possible concussion during the first quarter. Ali recorded one solo tackle before exiting. Justice Hill is next in line to take over his kickoff-return duties.
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Rasheen Ali RB | BAL
Ravens' Rasheen Ali: Might have concussion
Ali is getting evaluated for a possible concussion during Baltimore's matchup with Cleveland on Sunday.
The running back and special-teamer exited in the first quarter, but he did record a solo tackle before leaving the contest. Ali finished with 167 kickoff-return yards in the Ravens' 41-40 loss to the Bills in Week 1, and in his absence, Justice Hill might be next in line to return kicks.
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Jordan James RB | SF
49ers' Jordan James: Healthy scratch vs. NOLA
James (coach's decision) is inactive for Sunday's game against the Saints, Briana Jeannel of the 49ers' official site reports.
The rookie fifth-rounder broke his finger in early August and was not cleared to play against the Seahawks in Week 1. James was able to fade an injury designation ahead of Sunday's game after logging a full practice Friday, but he'll observe the contest in street clothes while the 49ers roll with a three-man backfield of Brian Robinson, Isaac Guerendo and starter Christian McCaffrey. James' next chance to make his NFL regular-season debut is Week 3 against the Cardinals on Sunday, Sept. 21.
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Sione Vaki RB | DET
Lions' Sione Vaki: Inactive for Week 2
Vaki (hamstring) is inactive for Sunday's game against the Bears.
The running back was listed as doubtful for the matchup after missing Week 1 with the same injury. Vaki played mostly as a special teamer in 2024, as Detroit's crowded backfield of Jahmyr Gibbs, David Montgomery and Craig Reynolds made it hard to get offensive snaps. The second-year pro is in line for a similar role once he returns.
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Raheim Sanders RB | CLE
Browns' Raheim Sanders: Sitting out in Week 2
Sanders (coach's decision) is inactive for Sunday's game against the Ravens.
Sanders suited up as the Browns' No. 3 running back in the team's 17-16 loss to the Bengals in the season opener and was able to make an impact in his limited snaps, finishing with three yards and a touchdown on three carries. However, with rookie second-round pick Quinshon Judkins (not injury related) having been reinstated from the commissioner's exempt list and added back to the 53-man roster after turning in full practices Thursday and Friday, Sanders will slide to fourth on the depth chart at running back and won't dress Sunday. Unless the Browns lose Judkins, Jerome Ford or Dylan Sampson to an injury in a given week, inactive statuses could start to become the norm for Sanders, an undrafted rookie out of South Carolina.
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Kalel Mullings RB | TEN
Titans' Kalel Mullings: Inactive Sunday
Mullings (ankle) is inactive for Sunday's game against the Rams, Jim Wyatt of the Titans' official site reports.
The running back injured his ankle on a punt return during Tennessee's season-opening loss to the Broncos and proceeded to miss practice in the week leading up to this contest. With Tony Pollard and Julius Chestnut leading the Titans' backfield, Jordan Mims, who was elevated Saturday from the practice squad, will step in as the third option.
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Jaydon Blue RB | DAL
Cowboys' Jaydon Blue: Inactive for second straight game
Blue (coach's decision) is inactive for Sunday's game against the Giants.
The rookie fifth-round draft pick will have to wait at least one more week to make his NFL debut, as Dallas will proceed with Javonte Williams and Miles Sanders as its lone active running backs for the second straight game. Though Williams looks to be locked in as Dallas' lead back after producing two touchdowns and 64 total yards on 17 touches in the Week 1 loss to the Eagles, Blue could eventually unseat Sanders -- who committed a costly fumble in the opener -- for the No. 2 role as the season unfolds.
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Roschon Johnson RB | CHI
Bears' Roschon Johnson: Officially active
Johnson (foot) is active for Sunday's Week 2 matchup against the Lions.
Johnson missed the regular-season opener due to a foot injury, which allowed rookie Kyle Monangai to operate as the backup behind D'Andre Swift. Johnson returned to practice during Week 2 prep and didn't have an injury designation heading into Sunday, so he should be full-go against Detroit. However, Swift handled 81 percent of the offensive snaps against Minnesota, so there may not be many opportunities to go around, especially if Monangai remains part of the mix.
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Jaylen Wright RB | MIA
Dolphins' Jaylen Wright: Not playing Sunday
Wright (knee) is inactive for Sunday's game against the Patriots.
Wright will miss his second straight game to begin the season, but he appears to have made some tangible progress in his recovery from the minor right knee procedure he required in late August. After practicing in a limited fashion Thursday and Friday, Wright was able to take a doubtful designation into the weekend prior to being included on the Dolphins' Week 2 inactive list. The Dolphins will face a quick turnaround in Week 3 with a Thursday matchup in Buffalo, but the second-year running back could have a chance at making his 2025 debut in that contest if he's able to increase his practice activity within the next few days.
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Quinshon Judkins RB | CLE
Browns' Quinshon Judkins: Ready for NFL debut
Judkins (not injury related) is active for Sunday's game in Baltimore, Daniel Oyefusi of ESPN.com reports.
After missing all of training camp and the preseason while his legal status was in limbo following a July 12 arrest in Florida, Judkins was formally cleared of all charges in August, but he remained unsigned until Sept. 6. Due to Judkins' late signing, the Browns were granted a two-game roster exemption for the rookie, but the 21-year-old running back will end up missing just one contest after he was able to practice in full Thursday and Friday following a meeting with NFL officials Wednesday. According to Ian Rapoport of NFL Network, the Browns eventually expect Judkins to emerge as their lead running back "sooner rather than later," but because of the extensive practice time he's missed over the last few months, he'll be eased in with a light workload. Rapoport suggests that Judkins will see something resembling "backup running back snaps" in Week 2, perhaps somewhere in the range of 10-to-15 plays. With that in mind, Dylan Sampson and Jerome Ford are both expected to have roles in Cleveland's backfield Sunday, though it may not be long before Judkins ultimately leapfrogs both players on the depth chart.