Cook took 20 carries for 74 yards and had one reception on four targets for three yards in Sunday's 13-12 loss to Philadelphia.

Cook reached the 20-carry mark for the sixth time this season, but unlike the previous five occurrences, he failed to hit the century mark in rushing yards against the Eagles. It was also just the fourth time in 2025 that the star running back was held below 4.0 yards per carry. While the Georgia product isn't known for his work as a receiver, finishing with more targets (four) than receiving yards (three) certainly feels like a letdown. It has been an incredible overall campaign from Cook so far through 16 starts (307-1,606-12), so he will look to finish the regular season on a high note in a soft matchup against the Jets in Week 18.

Gainwell rushed the ball seven times for 26 yards in Sunday's 13-6 loss to the Browns. He added three receptions on four targets for 12 yards.

The entire Steelers' offense was inefficient, and Gainwell's production similarly suffered. Positively, he maintained his role as Pittsburgh's primary pass catcher out of the backfield and ended the game with only two touches fewer than Jaylen Warren. However, Gainwell was held to his fewest yards from scrimmage since Week 10 heading into a pivotal Week 18 showdown with the Ravens that will decide the AFC North.

Guerendo (coach's decision) is inactive for Sunday night's contest against Chicago.

Guerendo will be a healthy scratch for the second straight week after having played in the team's previous 14 contests. Jordan James will get another nod as the 49ers' No. 3 running back behind Christian McCaffrey and Brian Robinson in Week 17.

Warren rushed the ball 12 times for 64 yards in Sunday's 13-6 loss to the Browns.

The Steelers' backfield usage remained consistent from the last few weeks, with Warren serving as the primary rusher but losing out on opportunities as a pass catcher. He managed to make the most of his opportunity with long rushes of 15 and 13 yards, and his 5.3 yards per attempt marked one of his more efficient performances of the season. However, given the split backfield in Pittsburgh, Warren is reliant on finding the end zone to have a strong fantasy performance. He has a good chance of recording double-digit carries in a win-or-go-home matchup with the Ravens in Week 18.

Hubbard carried the ball four times for 12 yards and caught all three of his targets for six yards in Sunday's 27-10 loss to the Seahawks.

The Panthers' offense couldn't get anything going Sunday until it was too late, and Hubbard wound up with his lowest scrimmage yards total since Week 10, when the Saints held him to just 15 yards. Hubbard hasn't seen double-digit touches in three straight games since Carolina's bye while Rico Dowdle fills the No. 1 role in the backfield, but he may need to step up in Week 18 against the Buccaneers with the NFC South, and a playoff spot, on the line with a Carolina win. Note that the Panthers can also win the division if the Falcons win their next two games, no matter what Carolina does in the finale.

Dowdle carried the ball 12 times for 59 yards and caught three of five targets for four yards in Sunday's 27-10 loss to the Seahawks.

The Panthers' offense couldn't get anything going Sunday until it was too late, and Dowdle wound up falling short of 60 rushing yards for the seventh straight game. Despite the late-season slump, the fifth-year back is still just 14 rushing yards short of setting a new career high after amassing 1,079 yards with the Cowboys in 2024. Dowdle may need to find another gear in Week 18 against the Buccaneers with the NFC South title, and a playoff spot, on the line with a Carolina win. Note that the Panthers can also win the division if the Falcons win their next two games, no matter what Carolina does in the finale.

Wright rushed five times for 56 yards in the Dolphins' 20-17 win over the Buccaneers on Sunday.

The backup running back flashed with a 32-yard run, the longest of his two-year career. Wright also had scored a touchdown in two of the previous three contests and eclipsed 100 yards in one of them, so he's delivered some deep-league, late-season utility behind De'Von Achane. Wright could be the beneficiary of some extra run if head coach Mike McDaniel opts to reduce the snaps of some of his top players in a Week 18 road matchup against the Patriots.

Charbonnet carried the ball 18 times for 110 yards and two touchdowns and caught both his targets for 12 yards in Sunday's 27-10 win over the Panthers.

The 110 rushing yards were a season high for Charbonnet, and he put together his second two-TD performance of 2025 with a two-yard plunge in the third quarter and a one-yard score in the fourth. Charbonnet has gotten into the end zone six times in the last eight games, amassing 426 rushing yards over that stretch with a 4.9 YPC. The Seahawks are headed toward the No. 1 seed in the NFC with one more win, so Charbonnet figures to remain heavily involved in Week 18 against the 49ers.

Estime rushed 14 times for 94 yards and a touchdown while bringing in his only target for four yards in the Saints' 34-26 win over the Titans on Sunday.

After both Estime and fellow back Evan Hull ceded plenty of work to jack-of-all-trades veteran Taysom Hill in a Week 16 win over the Jets, head coach Kellen Moore opted for a more traditional ground attack Sunday. Estime was the primary beneficiary, outpacing Hill and Hull by three and two carries, respectively, and recording a career-best rushing yardage total in the process. The 2024 fifth-round pick of the Broncos ripped off a 32-yard touchdown run to seal the win with just under four minutes remaining, and given his production, Estime looks like a strong candidate to helm the running game again in a Week 18 road matchup against the Falcons, assuming Alvin Kamara (knee) remains out.

Henderson (concussion) rushed 19 times for 82 yards and wasn't targeted in Sunday's 42-10 win over the Jets.

Henderson had a 19-8 edge in carries over Rhamondre Stevenson, but Stevenson had all five of the targets between the two and scored both of the touchdowns among New England's running backs. Henderson cleared concussion protocol prior to Sunday's win and avoided any setbacks, so the rookie second-round pick will continue to operate as the 1A option in New England's productive running back platoon in Week 18 against the Dolphins. The Patriots would secure the top seed in the AFC with a win over Miami and a Broncos loss to the Chargers.