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James Cook RB | BUF
Bills' James Cook: Trending toward playing Monday
Cook (toe) is expected to practice in limited fashion Saturday and is trending toward playing Monday against the Jets, Adam Schefter of ESPN reports.
Schefter seems plugged into this situation given the Bills technically haven't practiced yet Saturday. Cook was a DNP for both Thursday and Friday practices, so any upgrade seems to be a solid affirmation of the aforementioned report. Expect more confirmation to arrive in the coming days, but should Cook play, both Ty Johnson and Ray Davis would likely continue to operate as a backup platoon out of the backfield.
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James Cook RB | BUF
Bills' James Cook: Expected to be questionable for MNF
Head coach Sean McDermott expects Cook (toe) to be listed as questionable for Monday's contest against the Jets, Adam Schefter of ESPN reports.
This news tidbit comes before the Bills will practice Saturday, so it's fair to say there's likely more context to come after this initial announcement. Expect further information later in the day.
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Jaylen Warren RB | PIT
Steelers' Jaylen Warren: Cleared to face Raiders
Warren (knee) has been upgraded from his prior listed questionable status and will not carry an injury designation ahead of Sunday's game against the Raiders, Burt Lauten of Steelers.com reports.
After logging limited practices Wednesday and Thursday, Warren practiced fully Friday, with coach Mike Tomlin noting afterward that the running back headed into the weekend on a "good trajectory on the upswing." Now that Warren -- who had missed two straight games -- has been cleared to face Las Vegas on Sunday, he's in a position to reclaim a portion of the Steelers' backfield duties alongside Najee Harris, a context that makes him a lineup consideration for those in deeper formats or who are in need of Week 6 RB help due to injuries or bye week issues.
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Patrick Taylor RB | SF
49ers' Patrick Taylor: Extra work Thursday
Taylor rushed five times for 16 yards and caught his lone target for 12 yards in Thursday's 36-24 win over Seattle.
Starter Jordan Mason (shoulder) missed chunks of Thursday's victory due to injury, opening the door for Isaac Guerendo (10-99-0) and Taylor to split snaps in the interim. The 49ers' fourth-round rookie had the standout performance in the starter's absence, while Taylor produced just 3.2 yards per tote in his first action on offense this season. The 26-year-old Taylor could maintain a small role in San Francisco's Week 7 game plan if Mason is forced to sit against Kansas City due to the AC joint injury he sustained Thursday.
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Rasheen Ali RB | BAL
Ravens' Rasheen Ali: Deemed questionable
Ali (neck) is questionable for Sunday's game against the Commanders.
Ali has practiced in full for the last two weeks, but the Ravens don't need to rush him back thanks to a stable backfield of Derrick Henry and Justice Hill. If he is activated from injured reserve, Ali should be set for his NFL debut.
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Audric Estime RB | NO
Broncos' Audric Estime: Week 6 status TBD
Estime (ankle) practiced fully this week and is listed as questionable for Sunday's game against the Chargers, Susanna Weir of the Broncos' official site reports.
Estime was designated for return from injured reserve Wednesday, so he'll need to be activated to the 53-man roster by Saturday afternoon in order to be available for Sunday's contest. If the 2024 fifth-rounder does suit up this weekend, he'd be in line to provide Denver with backfield depth behind Javonte Williams and Jaleel McLaughlin.
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Dameon Pierce RB | PHI
Texans' Dameon Pierce: No Week 6 injury designation
Pierce (hamstring) doesn't carry an injury designation ahead of Sunday's game against the Patriots.
Pierce, who hasn't played since Week 1, is poised to return to action Sunday after logging full practices Thursday and Friday. In his looming return, Pierce's Week 6 fantasy upside hinges largely on the availability of Joe Mixon (ankle), who is listed as questionable but trending toward being available versus New England, per Aaron Wilson of KPRC 2 Houston.
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Zamir White RB | NO
Raiders' Zamir White: Questionable after return to practice
White (groin) is listed as questionable for Sunday's game against the Steelers after returning to a limited practice Friday.
White, who missed last Sunday's loss to the Broncos, didn't practice Wednesday or Thursday, but his limited session Friday could potentially open the door for him to return to action this weekend. If, however, White remains sidelined versus Pittsburgh for Las Vegas' 4:05 p.m. ET kickoff, Alexander Mattison would be in line to continue to work as the Raiders' lead back Week 6, with Ameer Abdullah available to handle a key change-of-pace role.
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Pierre Strong Jr. RB | GB
Browns' Pierre Strong: Ready to rock
Strong (hamstring) has no injury designation ahead of Sunday's matchup against the Eagles, Daniel Oyefusi of ESPN.com reports.
The South Dakota State product upgraded to full practice Friday after logging limited sessions both Wednesday and Thursday, suggesting that he's moved past his hamstring issue. Expect Strong to serve as the Browns' No. 3 running back Week 6, playing behind both Jerome Ford and D'Onta Foreman.
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Gus Edwards RB | LAC
Chargers' Gus Edwards: Won't play Sunday
Edwards (ankle) has been ruled out for Sunday's game against the Broncos.
With Edwards out versus Denver, Hassan Haskins and Kimani Vidal are candidates to see added complementary snaps this weekend behind top RB J.K. Dobbins. Edwards thus will target a potential return to action Monday, Oct. 21 against the Cardinals.