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Jamari Thrash WR | CLE
Browns' Jamari Thrash: Out for Week 12
Thrash (foot) has been ruled out ahead of Sunday's matchup against the Raiders, Daniel Oyefusi of ESPN.com reports.
The 24-year-old wideout from Louisville didn't practice Thursday due to a foot injury and is now in line to miss his second game of the season in Week 12. Thrash has appeared in nine games this year, catching 10 of 15 targets for 107 yards over 216 offensive snaps. While he's out Sunday, Gage Larvadain could have an expanded role in Cleveland's wide receiver corps.
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Bailey Zappe QB | NYJ
Bailey Zappe: Operating as No. 2 QB
Zappe will operate as the Browns' No. 2 quarterback in Sunday's matchup against the Raiders, Daniel Oyefusi of ESPN.com reports.
With Dillon Gabriel (concussion) being ruled out for the Week 12 matchup, the Western Kentucky product will back up Shedeur Sanders in his first career NFL start. Zappe started one game for the Browns in 2024, completing 16 of 31 passes for 170 yards, one touchdown and two interceptions.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Listed as questionable
Kamara (ankle) will be listed as questionable for Sunday's game against the Falcons, Luke Johnson of The New Orleans Times-Picayune reports.
Kamara's presence on injury reports has been a constant for New Orleans since he hurt his ankle during a practice in early October. A Week 11 bye apparently didn't change anything, with the Saints now listing Kamara as questionable for a third straight game. He's yet to actually miss a game this year, and he even took a season-high 22 carries his last time out, finishing with 115 total yards on 25 touches in the Week 10 win over Carolina.
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Isiah Pacheco RB | DET
Chiefs' Isiah Pacheco: Ruled out for Week 12
Coach Andy Reid ruled out Pacheco (knee) for Sunday's game against the Colts, Jesse Newell of The Athletic reports.
Pacheco has been sidelined since Week 8 due to a sprained MCL, but he was able to practice fully Wednesday and log a limited session Thursday, marking the first notable progress in his recovery. Reid also told Charles Goldman of AtoZSports.com that Pacheco didn't have a setback, and his return to practice this week was "literally to see where he's at." Pacheco thus will turn his focus to a Thanksgiving Day game at Dallas, while Kareem Hunt will continue to lead the Chiefs backfield this weekend.
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DeForest Buckner DT | IND
Colts' DeForest Buckner: Coach optimistic for return in 2025
Head coach Shane Steichen said Friday that he's optimistic Buckner (neck) will return during the 2025 season, James Boyd of The Athletic reports.
Buckner has been on injured reserve since Nov. 7 due to a neck injury, but he has been in the building with teammates as the veteran defensive tackle works his way back from the injury. The earliest Buckner will be eligible to return is Dec. 14 against the Seahawks in Week 15.
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Jamel Dean CB | PIT
Buccaneers' Jamel Dean: Out for Week 12
Dean (hip) has been ruled out ahead of Sunday's matchup against the Rams, Greg Auman of Fox Sports reports.
The Auburn product is now in line to miss his second game of the season after sustaining a hip injury in the Week 11 loss to the Bills. Dean is an integral part of Tampa Bay's secondary, recording 28 total tackles, including 1.0 sacks, and six passes defensed, with three interceptions, over just nine appearances this season. While he's out in Week 12, expect rookie Benjamin Morrison to operate as one of the Bucs' top boundary corners.
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Haason Reddick OLB | TB
Buccaneers' Haason Reddick: Won't play Sunday
Reddick (ankle/knee) has been ruled out ahead of Sunday's matchup against the Rams, Greg Auman of Fox Sports reports.
The 31-year-old didn't practice Wednesday or Thursday and is now in line to miss his fourth consecutive game due to ankle and knee injuries. While Reddick remains sidelined, expect Anthony Nelson to continue starting opposite Yaya Diaby in the Buccaneers' linebacker corps.
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Savion Williams WR | GB
Packers' Savion Williams: Not practicing Friday
Williams (foot) isn't practicing Friday, Mike Spofford of the Packers' official site reports.
Williams will likely be listed as questionable, at best, when the Packers release their injury report later Friday, as the rookie third-round pick managed just one limited practice Thursday sandwiched between two absences. Green Bay is banged up at wide receiver, but even in the off chance Williams gets the green light Sunday against the Vikings, his contributions would likely be limited primarily to returning kickoffs on special teams.
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Drake London WR | ATL
Falcons' Drake London: Officially ruled out
London (knee) has been ruled out for Sunday's game at New Orleans, Tori McElhaney of the Falcons' official site reports.
He didn't practice at all this week, after suffering a PCL sprain toward the end of an overtime loss to the Panthers on Sunday. With London out for at least one game and QB Michael Penix (knee) done for the season, Atlanta will rely on the likes of QB Kirk Cousins and WRs KhaDarel Hodge and David Sills.