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Michael Carter RB | TEN
Cardinals' Michael Carter: Dominates opportunity
Carter rushed the ball 18 times for 51 yards and a touchdown in Sunday's 22-21 loss to the Titans. He added five receptions on five targets for 22 yards.
Carter was expected to step into an expanded role with both James Conner (foot) and Trey Benson (knee) sidelined, though it was unclear exactly how touches would be distributed. Carter resoundingly served as the lead back for Arizona, accounting for 23 total touches, while Emari Demercado and Bam Knight combined for nine. He wasn't particularly efficient with the touches, though he did manage to find the end zone on a one-yard plunge early in the first quarter. Carter's involvement as a receiver was also particularly notable, as Demercado was projected to take over duties as the primary pass catcher out of the backfield. Carter looks to have reliable volume heading into a Week 6 matchup against the Colts, though this situation could remain fluid.
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Keon Coleman WR | BUF
Bills' Keon Coleman: Tallies key score in loss
Coleman recorded four receptions on seven targets for 23 yards and a touchdown in Sunday's 23-20 loss to the Patriots.
Coleman finished second on the team with seven targets, though he struggled to an inefficient performance like many of Buffalo's skill-position players. Both of his notable catches came in the fourth quarter, starting with a two-yard touchdown reception midway through the period. One possession later, he made a leaping, contested grab that went for 13 yards to help set up a game-tying field goal. While Coleman made key contributions for the team, he now has fewer than 30 receiving yards in three of five games for the season.
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Jihaad Campbell LB | PHI
Eagles' Jihaad Campbell: Double-digit stops in loss
Campbell recorded 11 total tackles (six solo) in Sunday's 21-17 loss to the Broncos.
Campbell was able to reach double-digit takedowns for the first time in his young career, finishing second only to fellow linebacker Zack Baun (12) in tackles. Campbell has hit the ground running in his rookie campaign, compiling 33 total tackles (18 solo), while also adding an interception and a forced fumble over five games this season.
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Khalil Shakir WR | BUF
Bills' Khalil Shakir: Six catches in loss
Shakir recorded six receptions on nine targets for 45 yards in Sunday's 23-20 loss to the Patriots.
Shakir matched his season high of nine targets, though he wasn't able to turn that into much production. Four of his six catches went for six or fewer yards, leading to his third performance with less than 50 receiving yards on the campaign. Shakir will continue to be a key part of the Buffalo offense, but he's reliant primarily on yards after the catch or touchdowns for big fantasy performances, with the majority of his opportunity coming in the short areas of the field.
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Zack Baun LB | PHI
Eagles' Zack Baun: Secures 12 tackles in loss
Baun recorded 12 total tackles (seven solo), including 1.0 sacks, in Sunday's 21-17 loss to the Broncos.
Baun was able to reach double-digit stops for the first time this season after doing so eight times during the 2024 regular season. He was also able to get to Bo Nix in the fourth quarter, registering a sack for the second straight week. Through five games this season, the linebacker has compiled 42 total tackles (26 solo), including 2.0 sacks, while also adding an interception and a forced fumble.
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Sterling Shepard WR | NYJ
Buccaneers' Sterling Shepard: Nabs first TD reception of 2025
Shepard finished with four receptions on five targets for 24 yards and a touchdown while losing five yards on his only rushing attempt in Sunday's 38-35 win over Seattle.
Shepard overcame a minor foot injury early in the practice week in order to suit up without restrictions in Sunday's win. The 32-year-old continued serving as the Buccaneers' No. 3 receiver, occupying the vacancy left by Mike Evans (hamstring) in Weeks 4 and 5 after filling in for Chris Godwin over the team's first three contests. If Evans remains sidelined for next Sunday's tilt against the 49ers, Shepard can continue providing value in Week 6 for those in deeper formats.
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Brock Wright TE | DET
Lions' Brock Wright: Two catches in win
Wright caught two of three targets for nine yards and a touchdown in Sunday's 37-24 win over Cincinnati.
Wright was able to find the end zone for the second time this season, reeling in a three-yard score on a pass from running back David Montgomery in the second quarter. The tight end remained a distant No. 2 option at his position behind Sam LaPorta, who secured five receptions for 92 yards and a touchdown in the game. Wright had gone two consecutive games without a catch prior to Sunday, and he's now caught five of six targets for 37 yards and two touchdowns over five games this season.
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Dalton Kincaid TE | BUF
Bills' Dalton Kincaid: Career-best performance
Kincaid recorded six receptions on six targets for 108 yards in Sunday's 23-20 loss to the Patriots.
Buffalo's offense looked out of sync for much of the game, but Kincaid was a bright spot. He recorded the first 100-yard receiving performance of his career in both regular-season and postseason contests, powered by a very efficient effort on six targets. Kincaid caught three passes of at least 20 yards, matching his total from the first four games of the season. Kincaid has also earned exactly six targets in three of his last four games, making him reliably involved in one of the most efficient offenses in the league.
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Isaac TeSlaa WR | DET
Lions' Isaac TeSlaa: Finds paydirt in Week 5
TeSlaa caught his only target for a 12-yard touchdown in Sunday's 37-24 win over the Bengals.
TeSlaa wasn't a major part of the offense again in Week 5, but he was able to make the most of his only opportunity, reeling in a 12-yard score in the fourth quarter. Fellow wide receiver Kalif Raymond suffered a neck injury in the second quarter of the contest, and he was unable to return to the game. If Raymond is forced to miss any action moving forward, TeSlaa would likely see an uptick in workload behind Amon-Ra St. Brown and Jameson Williams as the team's No. 3 option at wideout.
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TreVeyon Henderson RB | NE
Patriots' TreVeyon Henderson: Leads team with 24 rushing yards
Henderson carried the ball six times for 24 yards and caught two of three targets for three yards in Sunday's 23-20 win over Buffalo.
Henderson finished as New England's leading rusher as part of a three-player committee, but it was Rhamondre Stevenson who cashed in both of the team's short rushing scores Sunday. The latter also coughed up his third fumble of the season, which could cut into Stevenson's playing time even after making two trips to the end zone. That potential scenario could open up more touches for Henderson going forward, though so far he has seen his fantasy value thwarted by the three-way timeshare. Until he has an uptick in usage, the second-round rookie will be stuck as a deep-league option.