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Lamar Jackson QB | BAL
Ravens' Lamar Jackson: Hurts hamstring Sunday
Jackson is questionable to return to Sunday's game against Kansas City due to a hamstring injury.
Prior to his exit from Sunday's contest, Jackson completed 14 of his 20 passing attempts for 147 yards with a touchdown and interception while adding six carries for 48 yards. Cooper Rush has stepped in at quarterback for the Ravens in Jackson's stead.
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Justin Herbert QB | LAC
Chargers' Justin Herbert: Picked off twice in loss
Herbert completed 23 of 41 passes for 203 yards and a touchdown with two interceptions in Sunday's 21-18 loss to the Giants. He added 24 rushing yards on his only carry and ran for a two-point conversion.
The 27-year-old quarterback committed multiple turnovers for the first time in 2025 while throwing for a season low in passing yards as the Chargers took their first loss, but Herbert did salvage his day to some extent with a 36-yard TD to Quentin Johnston late in the second quarter. Herbert still has a respectable 7:3 TD:INT through four games heading into a Week 5 tilt against a Commanders defense that just gave up career-best numbers to the Falcons' Michael Penix.
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Tony Pollard RB | TEN
Titans' Tony Pollard: Totals 76 yards
Pollard rushed the ball 14 times for 64 yards in Sunday's 26-0 loss to the Texans. He caught all three of his targets for 12 yards.
Pollard had moments of effectiveness, recording his first rush of at least 20 yards with a gain of 21 early in the second quarter. He also had a decent chunk run of 11 yards one quarter later to reach at least 60 rushing yards for the third time in four games this season. While Pollard has played relatively well, the Tennessee offense is so ineffective that it's hard for any skill-position player to maintain consistent fantasy value, and the eventual return of Tyjae Spears (ankle) will likely cut into Pollard's touch volume.
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Chuba Hubbard RB | CAR
Panthers' Chuba Hubbard: Manages 69 total yards in loss
Hubbard rushed 10 times for 49 yards and brought in all three of his targets for 20 yards in Sunday's 42-13 loss to the Patriots.
Hubbard's rushing opportunities were unsurprisingly limited in the lopsided loss, but he made good use of them on his way to a team-high yardage total on the ground. The fifth-year pro's carry total tied for his lowest of the season, and he's now posted multiple receptions in all four contests to date in 2025. Hubbard should have a better chance at more rushing volume in a Week 5 home matchup against the Dolphins next Sunday afternoon, a game Miami's suspect defense will play on a short week.
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Omarion Hampton RB | LAC
Chargers' Omarion Hampton: Shines against Giants
Hampton carried the ball 12 times for 128 yards and a touchdown and caught all five of his targets for 37 yards in Sunday's 21-18 loss to the Giants.
The rookie running back capped his huge performance with a 54-yard touchdown run late in the fourth quarter as the Chargers tried to mount a comeback. Hampton has erupted for 294 yards from scrimmage and two TDs over the last two games as he takes over as the Chargers' unquestioned lead back in the absence of Najee Harris (Achilles), and he could be poised for big numbers once again Week 5 against a Commanders defense that just got steamrolled for 181 combined yards and a score by the Falcons' Bijan Robinson.
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Spencer Rattler QB | NO
Saints' Spencer Rattler: Logs season-low output versus Bills
Rattler completed 18 of 27 passes for 126 yards and one touchdown during Sunday's 31-19 loss against the Bills.
Rattler attempted fewer than 34 passes and threw for under 200 yards for the first time this season. The second-year quarterback has been underwhelming despite averaging 39.7 passing attempts through the first three regular-season games. Sunday's outing also marked the first time this season that the Saints have had more rushing attempts (34) than passing attempts (28). Rattler's production may suffer again if the Saints lean into the running game during their Week 5 matchup against the Giants, whose defense has allowed a league-worst 6.1 yards per carry.
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Marlon Humphrey CB | BAL
Ravens' Marlon Humphrey: Ruled out for rest of Week 4
Humphrey (calf) has been ruled out for the rest of Sunday's game against Kansas City, Matt Derrick of ChiefsDigest.com reports.
Humphrey sustained the calf injury in the first half, and after being evaluated by medical staff, the injury is considered too severe for him to return to Sunday's contest. Keyon Martin will continue to see additional snaps at corner in Humphrey's absence.
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Roquan Smith ILB | BAL
Ravens' Roquan Smith: Won't return vs. Kansas City
Smith (hamstring) has been ruled out for the rest of Sunday's game against the Chiefs, Matt Derrick of ChiefsDigest.com reports.
Smith suffered the injury in the second quarter of Sunday's game, and he will not return for the second half. Jay Higgins and Trenton Simpson will pick up the slack at inside linebacker the rest of the way due to Smith's injury.
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Ricky Pearsall WR | SF
49ers' Ricky Pearsall: Injures knee Sunday
Pearsall sustained a right knee injury during Sunday's contest against the Jaguars, Eric Branch of the San Francisco Chronicle reports.
After attempting to haul in a Brock Purdy pass early in the third quarter down the left sideline, Pearsall was shaken up and spent some time in the blue medical tent before the 49ers deemed him questionable to return. At the end of the same drive, Jauan Jennings appeared to injure his ribs as he gathered in a Purdy pass for a successful two-point conversion, so the statuses of the team's top wideouts are up in the air with more than a quarter left to play.