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Chris Godwin WR | TB
Buccaneers' Chris Godwin: Doesn't practice Friday
Godwin (ankle) didn't practice Friday.
Godwin was limited Thursday in his first practice since suffering a dislocated left ankle Week 7 of last season, signaling that he was beginning to ramp up his conditioning. His next step in that regard likely will be taking part in drills on back-to-back days, which, because it didn't happen this week, may be an indication that he isn't a great candidate to return to action Monday at Houston. Ultimately, Tampa Bay can make a decision on Godwin's status for that contest when it posts its final Week 2 injury report Saturday.
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Mac Jones QB | SF
49ers' Mac Jones: Getting first start under Shanahan
Jones will start Sunday's game at New Orleans in place of Brock Purdy (toe), Adam Schefter of ESPN reports.
There have long been rumors about Kyle Shanahan preferring Jones to Trey Lance -- but getting overruled by GM John Lynch -- ahead of the 2021 NFL Draft. The ship that Jones is captaining now isn't nearly as pretty as the one he would've been joining back then, as the 49ers currently have TE George Kittle (hamstring) and WR Brandon Aiyuk (knee) on injured reserve, with LT Trent Williams (knee) and WR Jauan Jennings (shoulder) listed as questionable. Jones gets a decent matchup, at least, playing indoors against a Saints team that's less talented than even this injury-riddled version of the 49ers. Reports suggest Jones is likely to start multiple games, although the Niners waited until Friday to rule Purdy out for Week 2.
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Jordan Watkins WR | SF
49ers' Jordan Watkins: Clear for potential pro debut
Watkins (ankle) doesn't have a designation for Sunday's game in New Orleans, Noah Furtado of the San Francisco Chronicle reports.
Watkins thus is set to make his pro debut after capping Week 2 prep with a full practice Friday, per Vic Tafur of The Athletic. The rookie fourth-round initially sustained a high-ankle sprain Aug. 9, but slightly more than a month removed from the injury, he's been cleared for game action. Watkins' eventual workload Sunday could be tied to whether or not veteran WR Jauan Jennings (shoulder) is able to suit up, but he'd still be vying with Ricky Pearsall, Kendrick Bourne, Marquez Valdes-Scantling and Skyy Moore for snaps and targets.
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Malik Hooker FS | DAL
Cowboys' Malik Hooker: Good to go for Week 2
Hooker (foot) doesn't carry an injury designation into Sunday's game against the Giants, Ralph Vacchiano of Fox Sports reports.
After back-to-back limited practices to begin the week, Hooker logged a full session Friday. Hooker played all 63 defensive snaps in the Cowboys' Week 1 loss to the Eagles and recorded nine tackles (four solo).
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Braxton Berrios WR | NYG
Texans' Braxton Berrios: DNP again Friday
Berrios (hamstring) remained sidelined at Friday's practice.
Berrios has yet to practice this season and looks poised to miss his second straight game to open the 2025 campaign. With Christian Kirk (hamstring) also hobbled, the Texans once again may use a committee approach at wide receiver behind Nico Collins this coming Monday night versus Tampa Bay.
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Foye Oluokun LB | JAC
Jaguars' Foyesade Oluokun: Cleared to play
Oluokun (illness) doesn't carry an injury designation into Sunday's game against the Bengals, Mia O'Brien of 1010 XL 92.5 FM Jacksonville reports.
After logging a DNP on Thursday, Oluokun was upgraded to a full practice Friday and is good to go for Sunday's Week 2 contest. The linebacker played all 64 defensive snaps last Sunday against the Panthers and recorded 10 tackles (five solo) and one interception in the victory.
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Brock Purdy QB | SF
49ers' Brock Purdy: Officially ruled out
Purdy (toe) has been ruled out for Sunday's game at New Orleans, Matt Maiocco of NBC Sports Bay Area reports.
Reports suggest he'll likely miss multiple games, but the 49ers waited until Friday to rule Purdy out for Week 2. Mac Jones will step in as the starting quarterback, manning an offense that won't have TE George Kittle (hamstring) or WR Brandon Aiyuk (knee) and may also be missing LT Trent Williams (questionable, knee) and WR Jauan Jennings (questionable, shoulder). Purdy's next chance to play is Week 3 against the Cardinals, although it doesn't sound likely even if the Niners leave things open-ended.
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Jauan Jennings WR | MIN
49ers' Jauan Jennings: Questionable for Week 2
Jennings (shoulder) is listed as questionable for Sunday's game at New Orleans, Matt Maiocco of NBC Sports Bay Area reports.
Jennings didn't finish the Week 1 win over Seattle or practice Wednesday and Thursday, but he returned Friday in a limited capacity, giving himself at least some chance to play ahead of a 1:00 p.m. ET kickoff. With QB Brock Purdy (toe) and TE George Kittle (hamstring) both ruled out, Jennings will project for a large target share if he plays, but without many of the surrounding conditions that have made San Francisco players so valuable for fantasy football in recent years. Standout left tackle Trent Williams (knee) also is listed as questionable.
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Kalel Mullings RB | TEN
Titans' Kalel Mullings: Doubtful for Week 2
Mullings (ankle) is doubtful for Sunday's game against the Rams.
Mullings was injured on a punt return in the first quarter of the Titans' Week 1 loss to the Broncos last Sunday. Tony Pollard and Julius Chestnut will handle backfield duties for the Titans against Los Angeles if Mullings can't suit up.
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Zavier Scott RB | CHI
Vikings' Zavier Scott: Cleared to play
Scott (ankle) doesn't carry an injury designation into Sunday night's game against the Falcons.
Scott will be making his season debut after he missed Week 1 against the Bears. With Ty Chandler (knee) placed on injured reserve earlier this week and set to miss at least the next four games, Scott is in line for RB3 duties behind Aaron Jones and Jordan Mason, though that likely won't translate to many, if any, offensive opportunities.