NFL Player News

James (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports.

The running back continues to be a healthy scratch for the 10th consecutive week. Christian McCaffrey, Brian Robinson and Isaac Guerendo remain ahead of James on the depth chart.

Nolen (knee) is active for Sunday's game against the 49ers, Darren Urban of the Cardinals' official site reports.

Nolen was limited in practice during Week 11 prep, but he has been given the green light to play Sunday after going through pregame warmups. The rookie first-rounder has posted six tackles (five solo), including 1.0 sacks, and one pass defense over his last two games.

Dike (concussion) won't return to Sunday's game against the Texans.

With Calvin Ridley (ankle) also ruled out for the rest of the contest, Elic Ayomanor, Van Jefferson and Mason Kinsey are now slated to handle the Titans' WR duties. Dike and Ridley will thus target a return to action next Sunday against the Seahawks.

Lenoir (calf) is active for Sunday's Week 11 matchup against Arizona, Eric Branch of the San Francisco Chronicle reports.

Lenoir dealt with a calf issue at the end of the week and was deemed questionable on Friday's final injury report. The Oregon product is ultimately going to play, which is a big development for the 49ers' secondary. Lenoir has logged every defensive snap for San Francisco each of the past seven weeks.

Bobo (coach's decision) is inactive for Sunday's game against the Rams, Brady Henderson of ESPN.com reports.

Bobo missed the Seahawks' last two games due to a calf injury. He was cleared of that injury during Week 11 prep, but he will still observe Sunday's game in street clothes as a healthy inactive. With Tory Horton (groin) also inactive, Cody White will serve in a rotational role at wide receiver behind Jaxon Smith-Njigba, Cooper Kupp and Rashid Shaheed.

Adams (oblique) is listed as active Sunday versus the Seahawks.

Adams initially was diagnosed with a back injury when he departed last Sunday's win at San Francisco in the fourth quarter. Coach Sean McVay told Nate Atkins of The Athletic afterward that Adams instead was dealing with an oblique issue but could have returned if the game was in question. When McVay told Lindsey Thiry of ESPN.com that Adams wouldn't practice Wednesday, he also said that he expected the veteran wide receiver to be available for Week 11 action. McVay relayed the same thing to Sarah Barshop of ESPN.com on Friday, and back-to-back limited sessions Thursday and Friday ended up being enough for Adams to suit up this weekend. Adams will be taking on a Seattle defense Sunday that has allowed the 20th-most catches (102) to opposing WRs but only 6.3 YPT (second in the NFL) in nine games this season.

Milroe (coach's decision) is inactive for Sunday's game against the Rams, but he will serve as the Seahawks' emergency third quarterback, Brady Henderson of ESPN.com reports.

Milroe will once again serve as the Seahawks' emergency QB3, which means he won't be allowed to play Sunday unless both Sam Darnold and Drew Lock leave the game due to injury, illness or ejection. Milroe last saw regular-season action in Week 5 against the Buccaneers.

Knight (ankle) is active for Sunday's game against the 49ers, Darren Urban of the Cardinals' official site reports.

Knight exited in the fourth quarter of last Sunday's loss at Seattle due to an ankle injury that left him limited on all three of the Cardinals' Week 11 practice reports. Adam Schefter of ESPN then reported Saturday evening that Knight was in line to play this weekend, which now will come to pass. Knight and Emari Demercado have split most of the touches afforded to the team's running backs over the last two games, with each earning 22 apiece. However, Demercado has been far more effective than Knight, out-producing him 182 to 80 in terms of yards from scrimmage during that span.

Newsome (ankle) has been ruled out for the rest of Sunday's game against the Chargers, John Shipley of SI.com reports.

Newsome sustained an ankle injury late in the first quarter, which is severe enough for him to not return to Sunday's game. Christian Braswell is slated to see more snaps at outside corner the rest of the way.

Smith was cleared to return to Sunday's game against the Bills after exiting the contest with a potential concussion.

Smith exited after a big stop in the second quarter with a potential concussion. The safety was able to clear the league's concussion protocol, passing an independent neurological evaluation to return to the game.