NFL Player News

Winfrey (back) has been ruled out for Thursday's contest against the Eagles, Mike Garafolo of NFL Network reports.

Winfrey suffered a lower back injury at practice Aug. 31, and he will now be forced to miss the team's regular-season opener in Philadelphia. In his absence, Jay Toia and Solomon Thomas could see an increase in workload at defensive tackle in Week 1.

Okuayinonu (shoulder) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.

Okuayinonu was sidelined for training camp practices due to a groin issue and was most recently working through a shoulder injury, but his full practice participation Wednesday indicates that he's on track to play Week 1 against the Seahawks on Sunday. Okuayinonu is slated to work in rotation at defensive end with Bryce Huff, Yetur Gross-Matos (knee), Nick Bosa and rookie first-rounder Mykel Williams.

Gross-Matos (knee) did not participate in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.

Gross-Matos opened training camp on the active/PUP list due to what was reported at the time as an undisclosed issue. He's no longer on the PUP list, but Wednesday's practice report revealed that the 2020 second-rounder has been working through a knee injury. Gross-Matos would need to return to practice in at least a limited capacity over the next two days to have a chance at playing in Sunday's regular-season opener against Seattle.

Young (hamstring) was a limited participant in Seattle's practice Wednesday, John Boyle of the team's official site reports.

Young's status for Sunday's season opener against the 49ers is now up in the air after he popped up on the team's injury report Wednesday. His availability in practice Thursday and Friday will provide more clarity on whether the 26-year-old will be able to suit up versus San Francisco.

Gardner-Johnson (knee) did not appear on the Texans' injury report Wednesday.

Gardner-Johnson suffered a knee injury in early August, but he avoided any major damage and will now be active for the team's regular-season opener against the Rams on Sunday. The 27-year-old is expected to operate as Houston's starting free safety in 2025.

West (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.

The rookie fourth-rounder hyper-extended his knee in mid-August, which prevented him from playing in the 49ers' final two preseason games. West was able to open the week with a full practice, which puts him on track to play in Sunday's regular-season opener against the Seahawks. He's expected to serve in a rotational role at defensive tackle with Alfred Collins, Kalia Davis and Jordan Elliott.

Stout (calf) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.

A calf injury prevented Stout from playing in any of San Francisco's preseason games. However, his full participation in Wednesday's practice indicates that the rookie-third rounder has recovered from the injury and is on track to play in Sunday's regular-season opener against Seattle. Stout should see a significant amount of playing time in the secondary with the 49ers' first-team defense alongside Deommodore Lenoir, Renardo Green, Ji'Ayir Brown and Jason Pinnock.

Williams (knee) practiced in full Wednesday, Cam Inman of The San Jose Mercury News reports.

The rookie first-rounder ended up missing all three of the 49ers' preseason games due to a knee injury that he suffered in early August. Williams was able to log a full practice to open the week, indicating that he is on track to make his NFL regular-season debut against the Seahawks on Sunday. He's expected to see a prominent role on the 49ers' defensive front alongside Nick Bosa, Kalia Davis and Jordan Elliott.

Pinnock (heel) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.

Pinnock did not play in the Niners' last two preseason games due to a lingering heel injury, but he appears to be past the issue and on track to play against the Seahawks on Sunday. With Malik Mustapha (knee) beginning the season on the reserve/PUP list, Pinnock is slated to serve in a starting role at safety alongside Ji'Ayir Brown.

Howden (oblique) was a limited participant in New Orleans' practice Wednesday.

Howden popped up on the injury report, leaving his status for Sunday's season opener versus the Cardinals up in the air. Once healthy, the 25-year-old is expected to serve as the team's backup strong safety behind Justin Reid and he likely will contribute on special teams as well.