Nationals vs. Pirates odds, line, prediction, time: 2025 MLB picks, April 15 best bets from proven model

The Pittsburgh Pirates and Washington Nationals will continue their four-game series in Pittsburgh on Tuesday after the Pirates defeated the Nationals, 10-3, on Monday in the series opener. The Pirates improved to 6-11 overall this season and snapped a three-game losing streak with the victory. The Nationals fell to 6-10 overall and have lost three straight games. Paul Skenes held Washington to just three base runners and two runs (one earned) with six strikeouts over six innings on Monday. The Pirates went 4-3 against Washington last season and have won the season series in each of the previous three years.

First pitch from PNC Park in Pittsburgh, Pa., is set for 6:40 p.m. ET. Pittsburgh is a -137 favorite on the money line (risk $137 to win $100) in the latest Pirates vs. Nationals odds, while Washington is a +116 underdog. The over/under is 8.5 in the latest MLB odds via SportsLine consensus. Before making any Nationals vs. Pirates picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 4 of the 2025 MLB season on an 8-3 run on MLB money-line betting picks (+340). Anybody following at sportsbooks and on betting apps could have seen strong returns.

Now, the model has set its sights on Pirates vs. Nationals and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Now, here are several MLB odds and betting lines for Nationals vs. Pirates:

• Pirates vs. Nationals money line: Pittsburgh -137, Washington +116 at Caesars Sportsbook
• Pirates vs. Nationals over/under: 8.5 runs
• Pirates vs. Nationals run line: Pittsburgh -1.5 (+156)
• WAS: The Over has hit in eight straight Nationals games
• PIT: Only three of Pittsburgh's six wins have come by multiple runs
• Pirates vs. Nationals picks: See picks at SportsLine
• Pirates vs. Nationals streaming: FuboTV (Try for free)

Read Review

Bet $1, Double Your Winnings Your Next 10 Bets

Up to $25 Max Bet Per Boost, code: CBSDYW

Must be 21+ and physically present in AZ, CO, DC, IA, IL, KY, LA, MD, ME, NY, OH, TN, VA, or WY. New users only. Must register using eligible promo code. Min. qualifying bet amount: $1. Tokens max. bet amount: $25 per token. Tokens bet max. add'l winnings: $2,500 per token. Token(s) expire 14 days after receipt. Not reissued for voided/pushed bets. Void where prohibited. See Caesars.com/promos for full terms. Know When To Stop Before You Start®. Gambling Problem? CO, IL, KY, MD, MI, NJ, OH, TN, VA, WV, WY, Washington, D.C. (OLG Class A licensed Operator), KS (Affiliated with Kansas Crossing Casino), LA (Licensed through Horseshoe Bossier City and Caesars New Orleans), ME (Licensed through the Mi’kmaq Nation, Penobscot Nation, and Houlton Band of Maliseet Indians, federally recognized tribes located in the State of Maine), NC (Licensed through Tribal Casino Gaming Enterprise), PA (Affiliated with Harrah's Philadelphia): If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) or MD: visit mdgamblinghelp.org or WV: visit 1800gambler.net; AZ: Call 1-800-NEXT-STEP; IN: Call 1-800-9-WITH-IT; IA: Call 1-800-BETSOFF. Data & text rates may apply. Gambling Problem? Call 1-800-GAMBLER, MA: Call 1-800-327-5050 or visit gamblinghelplinema.org, NY: Call 877-8-HOPENY or text HOPENY (467369).Must be 21+ and physically present in AZ, CO, DC, IA, IL, KY, LA, MD, ME, NY, OH, TN, VA, or WY. New users only. Must register using eligible promo code. Min. qualifying bet amount: $1. Tokens max. bet amount: $25 per token. Tokens bet max. add'l winnings: $2,500 per token. Token(s) expire 14 days after receipt. Not reissued for voided/pushed bets. Void where prohibited. See Caesars.com/promos for full terms. Know When To Stop Before You Start®. Gambling Problem? CO, IL, KY, MD, MI, NJ, OH, TN, VA, WV, WY, Washington, D.C. (OLG Class A licensed Operator), KS (Affiliated with Kansas Crossing Casino), LA (Licensed through Horseshoe Bossier City and Caesars New Orleans), ME (Licensed through the Mi’kmaq Nation, Penobscot Nation, and Houlton Band of Maliseet Indians, federally recognized tribes located in the State of Maine), NC (Licensed through Tribal Casino Gaming Enterprise), PA (Affiliated with Harrah's Philadelphia): If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) or MD: visit mdgamblinghelp.org or WV: visit 1800gambler.net; AZ: Call 1-800-NEXT-STEP; IN: Call 1-800-9-WITH-IT; IA: Call 1-800-BETSOFF. Data & text rates may apply. Gambling Problem? Call 1-800-GAMBLER, MA: Call 1-800-327-5050 or visit gamblinghelplinema.org, NY: Call 877-8-HOPENY or text HOPENY (467369).Must be 21+ and physically present in AZ, CO, DC, IA, IL, KY, LA, MD, ME, NY, OH, TN, VA, or WY. New users only. Must register using eligible promo code. Min. qualifying bet amount: $1. Tokens max. bet amount: $25 per token. Tokens bet max. add'l winnings: $2,500 per token. Token(s) expire 14 days after receipt. Not reissued for voided/pushed bets. Void where prohibited. See Caesars.com/promos for full terms. Know When To Stop Before You Start®. Gambling Problem? CO, IL, KY, MD, MI, NJ, OH, TN, VA, WV, WY, Washington, D.C. (OLG Class A licensed Operator), KS (Affiliated with Kansas Crossing Casino), LA (Licensed through Horseshoe Bossier City and Caesars New Orleans), ME (Licensed through the Mi’kmaq Nation, Penobscot Nation, and Houlton Band of Maliseet Indians, federally recognized tribes located in the State of Maine), NC (Licensed through Tribal Casino Gaming Enterprise), PA (Affiliated with Harrah's Philadelphia): If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) or MD: visit mdgamblinghelp.org or WV: visit 1800gambler.net; AZ: Call 1-800-NEXT-STEP; IN: Call 1-800-9-WITH-IT; IA: Call 1-800-BETSOFF. Data & text rates may apply. Gambling Problem? Call 1-800-GAMBLER, MA: Call 1-800-327-5050 or visit gamblinghelplinema.org, NY: Call 877-8-HOPENY or text HOPENY (467369).

Why the Nationals can cover

James Wood, who was the No. 1 prospect in baseball in July, is proving why he was the top prospect after making his first Opening Day roster. The 22-year-old outfielder has five home runs, 11 RBIs, 10 runs scored and three stolen bases with a .977 OPS over his first 15 games of the season. He has at least one hit in six of his last seven games while reaching base safely multiple times in each of those seven contests as someone who can be an offensive catalyst for Washington in multiple ways. 

The Nationals are scheduled to start right-handed pitcher Jake Irvin. The 28-year-old has a 5.63 ERA over three starts this season after posting a 4.41 ERA and 1.20 WHIP over 33 starts last year. His first three starts this season came against the Phillies, Diamondbacks and Dodgers, three of the strongest offenses in baseball, and he could perform closer to last year's season-long success against the Pirates, who rank last in baseball in batting average at .199 this season. See which team to back at SportsLine.

Why the Pirates can cover

Pittsburgh scored 10 runs off the Nationals on Monday, including six runs over 3 2/3 innings against a Washington bullpen that ranks last in baseball in ERA (6.92) and WHIP (1.92). The Pirates had five different players record multiple hits on Monday, including shortstop converted into outfielder Oneil Cruz. The 26-year-old was also considered one of the top prospects in baseball before making his MLB debut in 2021. Cruz had 21 home runs and 22 stolen bases last season and leads baseball with eight stolen bases over his first 13 games this season.

The Pirates are scheduled to start RHP Mitch Keller, who is 1-1 with a 4.24 ERA and 1.35 ERA this season. Keller hasn't allowed a home run over three starts this season and is coming off throwing 7 1/3 scoreless innings, scattering four hits with one walk with six strikeouts in a 2-1 victory over the Cardinals on Wednesday. He allowed just one run over six innings against the Marlins in his first start of the season and he's had a 4.25 ERA or less in each of the previous three seasons. See which team to back at SportsLine.

How to make Nationals vs. Pirates picks

SportsLine's model is leaning Over on the total, and it says one side of the money line is the better value. You can head to SportsLine to see the model's MLB picks. 

So who wins Pirates vs. Nationals, and which side is the better value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.

Where to bet on MLB games

Here are some of the sportsbooks to bet on MLB games today, along with the various MLB sportsbook promos they currently offer.