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The Boston Celtics and Portland Trail Blazers will play for the first time this season on Wednesday. The Celtics are second in the Eastern Conference at 43-18 overall, including 19-11 at home this season. The Blazers (28-34) are four games out of the final spot in the Western Conference NBA Play-In Tournament, but they've been playing some of their best basketball of the season over their current road trip. Portland is 4-1 in the middle of a seven-game road trip entering Wednesday. Jayson Tatum (shoulder) and Jaylen Brown (illness) are questionable for Boston, while Jerami Grant (knee) is questionable for Portland.

Tipoff is set for 7 p.m. ET from TD Garden in Boston. This is the first matchup of the season between the two, but the Celtics have won each of the last four meetings between the teams. The Celtics are favored by 9.5 points in the latest Blazers vs. Celtics odds, according to the SportsLine consensus. The over/under is 225 points. The Celtics are at -412 on the money line (risk $412 to win $100), with the Blazers at +320 (risk $100 to win $320). Before entering any Celtics vs. Blazers picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 20 of the 2024-25 NBA season on a sizzling 147-107 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It's also an outstanding 18-10 (64%) on top-rated spread picks this season. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has set its sights on Boston vs. Portland. You can head to SportsLine to see its picks. Here are several NBA betting lines for Blazers vs. Celtics:

  • Celtics vs. Blazers spread: Celtics -9.5
  • Celtics vs. Blazers over/under: 225 points
  • Celtics vs. Blazers money line: Celtics -412, Blazers +320
  • POR: The Trail Blazers are 5-1 against the spread (ATS) over their last six games
  • BOS: The Celtics are 6-3 ATS over their last nine games
  • Celtics vs. Blazers picks: See picks at SportsLine
  • Celtics vs. Blazers streaming: FuboTV (Try for free) 
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Why the Blazers can cover

The Trail Blazers may never want to return to Portland with how well this road trip is going. The Blazers are 4-1 seven games into their road trip, including 3-1 against the Eastern Conference. Portland is 4-0 ATS against Eastern Conference teams during this road trip. Anfernee Simons had 34 points in a 119-102 win over the 76ers on Monday on 13 of 26 shooting, including making 6 of 11 3-pointers. 

Shaedon Sharpe, the No. 7 overall pick in the 2022 NBA Draft, has scored at least 18 points in four straight games and is averaging 24.8 ppg over that stretch. He is second on the team in scoring at 17.5 ppg, behind Simons' 19 ppg, as the primary pieces in the Portland offense. The Blazers are an incredible 16-3 ATS against the Eastern Conference this season, covering in 84.2% of games, and are 31-21-1 ATS (59.6%) as an underdog this season. The Celtics will likely be shorthanded as along with Tatum and Brown as questionable, Jrue Holiday (hand) and Kristaps Porzingis (illness) are doubtful. See which team to pick here.

Why the Celtics can cover

The defending NBA Champions could be on their way to a repeat as the Celtics have the third-best record in the league. Boston is 11-3 over its last 14 games and has covered the spread in six of its last seven victories. Tatum is having another MVP-caliber season, averaging 26.8 points, 8.8 rebounds and 5.8 assists per game, and will be a total difference maker if active. Tatum had 46 points, 16 rebounds and nine assists in a 123-116 loss to Cleveland on Friday but Boston answered with a 110-103 win over the Nuggets on Sunday in a potential NBA Finals preview.

The Celtics are just one of two teams with a top 10 scoring offense and defense in the NBA. Boston is eighth in scoring (116.8 ppg), while ranking third in points allowed (108.2 ppg) this season. Guards Payton Pritchard (hip) and Derrick White (back) are probable as Boston has the depth to withstand some players potentially missing Wednesday while still covering a double-digit spread. See which team to pick here.

How to make Celtics vs. Trail Blazers picks

The model has simulated Trail Blazers vs. Celtics 10,000 times and the results are in. The model is leaning Under, projecting 216 combined points, and it also says one side of the spread hits well over 50% of the time. You can only see the pick at SportsLine.

So who wins Celtics vs. Blazers, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Blazers vs. Celtics spread you need to jump on, all from the model that is on a 147-107 roll on top-rated NBA picks since last season, and find out.

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