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Two Super Bowl contenders will collide when Patrick Mahomes and the Kansas City Chiefs visit Josh Allen and the Buffalo Bills on Sunday. The Chiefs enter Week 11 as the NFL's only undefeated team. Kansas City has won nine consecutive games to open the season, but the Chiefs are just 5-4 against the spread. The Chiefs are 2.5-point underdogs in the Week 11 NFL odds after the line opened at Kansas City -1. Other notable NFL spreads on the Week 11 NFL schedule include Ravens vs. Steelers (+3, 48.5), Bengals vs. Chargers (-1.5, 48) on Sunday Night Football, and Texans vs. Cowboys (+7.5, 42) on Monday Night Football. 

Making NFL score predictions on all 14 Week 11 games can help form not only NFL spread picks, but also NFL over/under picks, NFL parlay picks, and even your NFL survivor strategy and NFL office pool picks. Which Week 11 NFL games will be lopsided, and which ones will play out closer to their NFL betting odds? Before you make any Week 11 NFL picks, make sure you see what SportsLine's advanced computer model has to say

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 11 of the 2024 NFL season on an incredible 17-7 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 197-136 roll on top-rated NFL picks that dates back to the 2017 season and a 51-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns at their best sports betting app.

Now, the model has simulated every Week 11 game 10,000 times. You can only see the model's Week 11 NFL exact score predictions at SportsLine.

Top Week 11 NFL picks

After diving into every game on the Week 11 NFL schedule, the model is backing the Minnesota Vikings (-6, 39.5) to beat the Tennessee Titans, 22-18, on the road. Minnesota overcame a sloppy offensive display to secure a 12-7 victory on the road against the Jacksonville Jaguars last week. The Vikings didn't score a touchdown in the win and quarterback Sam Darnold threw three interceptions. 

However, the Vikings walked away with a much-needed victory thanks to their suffocating defense. Minnesota's defense gave up just 143 total yards against Jacksonville while recording three sacks and two interceptions. The Vikings are giving up 17.4 points per game this season, which ranks third in the NFL. The Vikings opened the season with five straight ATS wins.

The Titans, meanwhile, limp into Sunday's showdown having lost four of their past five games. Tennessee has failed to score more than 20 points during that five-game stretch. In addition, the Titans are 2-6 in their last eight meetings against the Vikings. SportsLine's model projects Darnold will throw for 229 yards and two touchdowns, while Minnesota's defense racks up four sacks on average. See the model's other Week 11 NFL score predictions at SportsLine

How to make Week 11 NFL score predictions

In addition, the model has locked in exact score predictions for this week's biggest matchups including Chiefs vs. Bills, Ravens vs. Steelers and Bengals vs. Chargers. It's also calling for a hefty home underdog to win outright, shocking the NFL. Nailing these results is key to making profitable Week 11 NFL picks. You can only see them at SportsLine

Who wins each Week 11 NFL game, and which upset shocks the NFL? Visit SportsLine now to get the model's NFL Week 11 score predictions, all from the model on a 197-136 roll on top-rated NFL picks, and find out.