Aaron Rodgers and the New York Jets have lost seven of their last eight games and now will host the Seattle Seahawks for a cross-conference matchup in Week 13. The Seahawks have won five straight against the Jets and Seattle is a 1.5-point favorite according to the latest Week 13 NFL odds. The Jets are also 3-8 against the spread this season, a trend many bettors will take into account before locking in their Week 13 NFL picks.

The Week 13 NFL schedule also features other cross-conference matchups like Eagles vs. Ravens (-2.5, 50.5) and 49ers vs. Bills (-7, 46) that could have a major impact on the NFL playoff picture. If you're looking for a big return on your football betting picks, nailing NFL score predictions can be highly profitable. Using a computer model's Week 13 NFL score predictions can help you crush your Week 13 NFL bets. Before you make any Week 13 NFL picks, make sure you see what SportsLine's advanced computer model has to say

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 of the 2024 NFL season on an incredible 22-8 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 202-136 roll on top-rated NFL picks that dates back to the 2017 season and a 56-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns at their best sports betting app.

Now, the model has simulated every Week 13 game 10,000 times. You can only see the model's Week 13 NFL exact score predictions at SportsLine.

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Top Week 13 NFL picks

After diving into every game on the Week 13 NFL schedule, the model is backing the Tampa Bay Buccaneers (-6, 46.5) to beat the Carolina Panthers, 29-18, on the road. The Buccaneers are coming off a dominant 30-7 victory over the Giants, while the Panthers suffered their eighth loss of the season in last week's setback against the Chiefs

Tampa Bay has also dominated this NFC South rivalry over the years, winning eight of the last 10 meetings against Carolina. The Bucs are 5-1 in their previous six games played in December and 12-3 against the spread in their past 15 games on the road. Tampa Bay features a top-10 rushing attack, averaging 128.1 yards per game, and now the Bucs will face a Carolina defense that's giving up 160.5 rushing yards per game, which ranks dead-last in the NFL. The model projects the Buccaneers to finish with well over 100 yards rushing, while Tampa Bay's defense racks up 2.78 sacks on average. See the model's other Week 13 NFL score predictions at SportsLine

How to make Week 13 NFL score predictions

In addition, the model has locked in exact score predictions for this week's biggest matchups including Steelers vs. Bengals, Eagles vs. Ravens and 49ers vs. Bills. It's also calling for multiple underdogs to pull off shocking NFL upsets. Nailing these results is key to making profitable Week 13 NFL picks. You can only see them at SportsLine

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Who wins each Week 13 NFL game, and which underdogs pull off shocking NFL upsets? Visit SportsLine now to get the model's NFL Week 13 score predictions, all from the model on a 202-136 roll on top-rated NFL picks, and find out.