The Week 13 NFL schedule means the playoff races are heating up and the weather is cooling down. We saw our first snow game last Thursday in Cleveland, and the elements could come into play with several contests on a super-sized Week 13 slate. After losing to the Browns, Pittsburgh will make another trip to Ohio as a 2.5-point road underdog at Cincinnati in the Week 13 NFL odds. In other NFL games where NFL weather could be a factor, the Patriots host the Colts (-2.5), the Jets host the Seahawks (-1.5) and the Bills host the 49ers (+7). You'll need to keep weather in mind before making any NFL betting picks.
Speaking of the Browns, they will get an extended mini-bye as their Thursday victory is followed by a Monday Night Football appearance. Browns vs. Broncos features a pair of squads that are very familiar with wintery conditions, and Denver is favored by 5.5 points at home, according to the Week 13 NFL Vegas odds, one of the larger NFL spreads of the week. All of the updated Week 13 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 13 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 13 of the 2024 NFL season on an incredible 22-8 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 202-136 roll on top-rated NFL picks that dates back to the 2017 season and a 56-29 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns.
Now, it has turned its attention to the latest Week 13 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick.
Top Week 13 NFL predictions
We can tell you one of the model's strongest Week 13 NFL picks is that the Saints (+2.5, 46.5) cover the spread at home versus the Rams. The model has New Orleans not only covering, but outright winning, as it has the Saints prevailing versus the spread well over 70% of the time. New Orleans has a rest advantage, coming off its bye, and the Saints have been revitalized under interim coach Darren Rizzi. The team has three offensive touchdowns of 40-plus yards since he took over two games ago, after the Saints had just one such score over its previous seven games combined.
The defense has also noticeably improved and allowed fewer points in each of its last five games, holding opponents to 17 or fewer in Rizzi's two games. As for L.A., it's coming off a game in which it allowed two touchdowns of 70-plus yards as the Rams defense ranks 26th or worse in points allowed, yards allowed and rushing defense. When you factor in that the Saints have beaten the Rams in four straight regular-season matchups in New Orleans, you can see why the SportsLine model is so bullish on the Saints (+2.5) covering as underdogs. See which other teams to pick here.
Another one of its Week 13 NFL predictions: the Jets (+1.5, 42) cover at home versus the Seahawks. New York is coming off a bye, while the Seahawks will have a cross-country flight, which hasn't been very conducive to them having success recently. The Seahawks have covered just once over their last five games in the Eastern Time Zone. Additionally, Seattle is just 1-5 straight-up over its last six road games versus the Jets.
This game pits Seattle's No. 2 passing offense versus New York's second-ranked passing defense, so with those two cancelling each other out, the run game could make the difference. That's where the Jets have the edge as just six teams allow fewer yards per rush than New York, while the Seahawks rank 28th in both rushing yards per game and yards per carry. The model has New York covering in over 50% of simulations, and it also says the Under hits almost 60% of the time. See which other teams to pick here.
How to make Week 13 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 13 NFL schedule and just revealed four teams that outright win at least 70% of the time, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So what NFL picks can you make with confidence, and which four teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
Week 13 NFL betting odds, lines, spreads
Get Week 13 NFL picks at SportsLine
| Game | Spread | Total | Picks |
| Bears at Lions (Thursday) | DET -10.5 | 48.5 | SEE PICKS HERE |
| Giants at Cowboys (Thursday) | DAL -4 | 39 | SEE PICKS HERE |
| Dolphins at Packers (Thursday) | GB -3 | 47.5 | SEE PICKS HERE |
| Raiders at Chiefs (Friday) | KC -13 | 42.5 | SEE PICKS HERE |
| Chargers at Falcons | LAC -1.5 | 47 | SEE PICKS HERE |
| Steelers at Bengals | CIN -2.5 | 47 | SEE PICKS HERE |
| Texans at Jaguars | HOU -5.5 | 43 | SEE PICKS HERE |
| Cardinals at Vikings | MIN -4 | 45.5 | SEE PICKS HERE |
| Colts at Patriots | IND -2.5 | 42.5 | SEE PICKS HERE |
| Seahawks at Jets | SEA -1.5 | 42 | SEE PICKS HERE |
| Titans at Commanders | WAS -5.5 | 43.5 | SEE PICKS HERE |
| Buccaneers at Panthers | TB -6 | 46.5 | SEE PICKS HERE |
| Rams at Saints | LAR -2.5 | 46.5 | SEE PICKS HERE |
| Eagles at Ravens | BAL -2.5 | 50.5 | SEE PICKS HERE |
| 49ers at Bills | BUF -7 | 46 | SEE PICKS HERE |
| Browns at Broncos (Monday) | DEN -5.5 | 41.5 | SEE PICKS HERE |