After eight outright upsets in Week 3, anybody making NFL picks in Week 4 is sure to be wary of hungry NFL underdogs. The Panthers convincingly beat the Raiders as 5.5-point underdogs last week, but they're 4.5-point dogs against the winless Bengals in the Week 4 NFL odds. Can the Panthers pull off another upset and how should you handle every game on the Week 4 NFL schedule as you make your Week 4 NFL score predictions and NFL picks?

Understanding NFL matchups and NFL trends can help ensure you're finding value as you make against the spread, money line and over/under bets. So before you make any Week 4 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

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In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine's AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 4 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. You can only see the AI predictions for the Week 4 NFL schedule here.

Top Week 4 NFL AI picks

After analyzing every game in Week 4, the AI PickBot says the Jaguars cover as 6.5-point road underdogs against the Texans. Both teams are coming off major letdowns in Week 3, with the Jaguars getting smashed, 47-10, by the Bills and the Texans losing 34-7 against the Vikings. Houston only rushed for 38 yards with Joe Mixon sidelined and the star running back is questionable for Week 4. 

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Meanwhile, the Jaguars got a huge day from Trevor Lawrence when they went to Houston last season. He threw 364 yards and a touchdown in a 24-21 win over the Texans. Jacksonville has won and covered two of its last three head-to-head matchups with Houston, a big reason why the AI PickBot grades the Jaguars against the spread as an A-rated pick. See its other Week 4 football predictions and football picks at SportsLine.

How to make Week 4 NFL picks

In addition, the AI PickBot has generated 11 other A-rated picks for Week 4. You need to see the AI PickBot's picks before making any Week 4 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 4 NFL game, and which A-rated picks should you target?  Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.

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