Santana (groin) will remain in Arizona and undergo an MRI on Monday, Alex Weiner of ArizonaSports.com reports.

Santana was forced to leave Sunday's extra-inning win over Atlanta in the bottom of second inning after pulling up lame with a right groin injury while legging out a single. The first baseman will now stick around Arizona for an extra day to undergo additional imaging while the rest of the squad travels to New York ahead of the team's three-game set against the Mets beginning Tuesday. Ildemaro Vargas replaced Santana at first base Sunday, and he could be the next man up if Santana is forced to miss any action moving forward.

O'Hearn went 2-for-5 with a double, a two-run home run and four RBI in Sunday's game against the Orioles.

O'Hearn kicked off the scoring with a two-run home run in the first inning, his third long ball of the season. He added a two-RBI double one frame later, his third multi-RBI effort of the campaign. O'Hearn has had a strong start to the season by collecting at least one hit in seven of eight games, and he's even started two of three contests against lefties.

Kayfus started in left field and went 1-for-2 with a double in a 1-0 loss to the Cubs in the first game of Sunday's doubleheader. He came off the bench in the nightcap and went 2-for-2 with a solo home run, two RBI and an additional run scored.

Kayfus recorded his first hit of the season and the Guardians' lone knock in the opening game. In the nightcap, he singled and drove in a run as a pinch hitter in the sixth inning, stayed in the game to play right field and tied the game in the eighth inning with a home run. The offensive production could lead to more opportunities for Kayfus, who entered Sunday having been held out of the starting lineup in the previous four games.

Santana left Sunday's game against Atlanta with right groin tightness.

Santana recorded a hit in his lone plate appearance Sunday and is hitting .083 in 26 plate appearances this season. It's unclear how much time Santana will miss with the injury. Ildemaro Vargas replaced Santana at first base.

Santana was removed from Sunday's game against Atlanta due to an apparent injury, Alex Weiner of ArizonaSports.com reports.

The veteran first baseman appeared to tweak something during his first plate appearance but remained in the game, only to be replaced by a pinch runner after hitting a single. Santana can be considered day-to-day for now, but his status should be updated in the near future.

Manzardo is out of the lineup for Game 2 of Sunday's doubleheader against the Cubs.

Manzardo went 0-for-3 with a walk during the matinee, extending his hitless streak to six games. He'll head to the bench for Game 2 while Chase DeLauter serves as the designated hitter, opening up right field for David Fry.

Smith is out of the lineup for Sunday's game against the Diamondbacks, Chad Bishop of The Atlanta Journal-Constitution reports.

Smith's three previous absences from the lineup this year came against lefty starters, but he's sitting Sunday despite the fact that right-hander Brandon Pfaadt is pitching for Arizona. Ronald Acuna is resting his legs as the DH, which allows Eli White to pick up a start in right field.

Hoskins is out of the lineup for Game 1 of Sunday's doubleheader against the Cubs, Tim Stebbins of MLB.com reports.

It's the second straight game on the bench for Hoskins despite the fact he's enjoyed a strong start to the campaign with four walks, two doubles and an .873 OPS through 18 plate appearances. Jose Ramirez is resting his legs as the designated hitter while CJ Kayfus enters the lineup in place of Hoskins, who will likely be back in action for Game 2.

Freeman went 2-for-5 with two doubles and four RBI in Saturday's win over the Nationals.

The All-Star first baseman has now totaled four bases in three straight games to begin April. Freeman has four extra-base hits over that span and has also collected seven RBI. He'd gone a quiet 4-for-20 in March, so Freeman is certainly starting to pick things up this month.

Aranda went 1-for-5 with a double, two RBI and three strikeouts in Saturday's win over the Twins.

Aranda made his presence felt in the top of the second inning with a bases-loaded double that scored both Ben Williamson and Richie Palacios. Aranda has gone just 1-for-13 in his last three games, but he's done damage when he makes contact this year with two doubles, two homers and seven RBI with an .818 OPS through 39 plate appearances.