The Orioles designated Pennington for assignment Wednesday, Jake Rill of MLB.com reports.

Pennington has made two appearances in the minors this season, during which he's given up five earned runs in one combined inning between High-A Aberdeen and Triple-A Norfolk. While he continues to work on his mechanics in the minors, he'll give up his spot on the Orioles' 40-man roster for Luis F. Castillo, who was claimed off waivers from the Mariners on Wednesday.

Chapman earned the save in Wednesday's 6-4 win over the Rangers, allowing one solo home run and one walk while striking out one batter in the ninth inning.

Chapman was brought in for the ninth frame with the Red Sox up 6-3, but Boston's lead was quickly cut down to two when Josh Jung took the first pitch of the at-bat deep to left-center field for a solo home run. Chapman yielded a walk later in the frame, but the veteran closer was able to finish things off with an eight-pitch punchout of Blaine Crim, with two of the southpaw's sinkers touching 103 mph. Chapman has five saves in as many opportunities this season with a 2.19 ERA, 1.05 WHIP and 18:5 K:BB over 12.1 innings, though he's been a bit shakier lately with two runs allowed in his past four outings.

Munoz earned the save in Wednesday's 6-5 win over the A's, allowing one hit while striking out two in a scoreless ninth inning.

After taking his first blown save of the year in the 10th inning of his last appearance, Munoz responded with a strong effort Wednesday to close out a one-run victory, picking up his 13th save this season, good for second most in the majors. The 26-year-old Munoz has yet to allow an earned run through his first 18 innings, posting a pristine 0.83 WHIP with 25:8 K:BB.

The Blue Jays optioned Tate to Triple-A Buffalo on Wednesday.

Since being promoted from Triple-A on April 20, Tate has surrendered three runs while logging a 7:6 K:BB in 5.1 innings across five appearances. He'll now head back to Buffalo to make room for Braydon Fisher, who was selected to the active roster in a corresponding move.

Harvey (shoulder) came away from his most recent live batting practice session Tuesday with a bit of soreness, Anne Rogers of MLB.com reports.

Manager Matt Quatraro said the team is going to ease up a bit on Harvey's progression and will go back to having the 30-year-old righty throw standard bullpen sessions. Once he's able to pitch without triggering any soreness, he'll likely resume work against live hitters.

Yankees manager Aaron Boone said Wednesday that Loasiga (elbow) will likely remain on his rehab assignment through May 18, Max Goodman of NJ.com reports.

Loaisiga was moved up to Triple-A Scranton/Wilkes-Barre on Wednesday to continue his rehab assignment, and Boone is "really excited" with where the reliever is at in his recovery from the internal brace procedure he underwent last April. However, given how little the 30-year-old has pitched the last couple seasons, the Yankees want to proceed slowly with him. Loaisiga allowed one run with a 7:0 K:BB over 3.1 innings during three rehab appearances with Single-A Tampa. He's looking at an activation from the 15-day injured list May 20 if all continues to go well.

Clase gave up a hit and struck out one in a scoreless ninth inning Wednesday to record his eighth save of the season in an 8-6 win over the Nationals.

After some early-season struggles, Clase appears to be regaining his usual form. The right-hander has converted four straight save chances, and he's given up just one earned run over his last six appearances with a 7:0 K:BB. He still has some work to do to dig out from the statistical hole he dug, however -- through 16.1 innings on the season, Clase carries a 5.51 ERA and 1.71 WHIP.

Booser (0-3) allowed two runs (one earned) on three hits and one walk while recording only one out to blow the save and take the loss Tuesday against the Royals.

Booser was brought in to protect a one-run lead in the ninth inning and suffered from a combination of poor pitching and bad luck. He walked the leadoff man, but Chase Meidroth had a pop fly bounce off his head one batter later. A subsequent pair of singles -- one of which didn't leave the infield -- gave the Royals the walk-off win. Booser started the season decently but has allowed six earned runs across his last 4.1 innings of work and doesn't look likely to continue to see save chances.

Leasure retired the only batter he faced in the eighth inning to earn a hold Tuesday against the Royals.

Leasure entered the game with the tying run at second base in the eighth inning and retired the only batter he faced on three pitches to escape the jam. He was surprisingly not brought back out for the ninth inning despite the light workload, with Cam Booser instead blowing a save chance and taking the loss. This usage suggests that Leasure is the White Sox's preferred highest-leverage reliever -- rather than designated closer -- though it's difficult to speculate on the closer role given that the team has only one save for the season.

The Guardians optioned Kent to Triple-A Columbus on Wednesday.

As expected, Kent was sent back to Columbus after he was called up Tuesday to serve as the 27th man in the Guardians' doubleheader versus the Nationals. Kent tossed a scoreless ninth inning in the Guardians' 9-1 win in Game 2, giving up one hit while striking out a batter.