Holmes struck out nine and walked one over five scoreless, no-hit innings in Thursday's Grapefruit League game against the Pirates.

The right-hander built up to 64 pitches (41 strikes) as he dominated a Pittsburgh lineup that featured most of its likely Opening Day starters, including Bryan Reynolds, Ryan O'Hearn and Marcell Ozuna. Holmes has yet to allow an earned run this spring, posting a 16:6 K:BB through 12.1 innings, and he's locked into an Opening Day rotation spot due to injuries to Spencer Schwellenbach (elbow), Hurston Waldrep (elbow) and Joey Wentz (knee).

With Matthew Boyd named Chicago's Opening Day starter, Imanaga could be the team's No. 3 pitcher behind Cade Horton, Jordan Bastian of MLB.com reports.

Imanaga was seen as an option for the Opening Day assignment, but Chicago will instead turn to Boyd for the third time in his career and first with the Cubs. The team hasn't officially announced its plans behind Boyd, though slotting Horton second and Imanaga third would allow Chicago to go lefty-righty-lefty. If Imanaga is the No. 3 starter, his first appearance of the regular season would be March 29 against the Nationals at Wrigley Field.

Hoeing (elbow) will undergo flexor tendon surgery and miss the entire 2026 season, Kevin Acee of the San Diego Union-Tribune reports.

Hoeing was shut down from throwing earlier this month and has now opted for season-ending surgery. The 29-year-old right-hander spent the bulk of his 2025 campaign with Triple-A El Paso but pitched in seven games out of the bullpen for the Padres, turning in a 3.38 ERA, 1.50 WHIP and 5:3 K:BB across eight innings.

Ferguson will open the season on the injured list due to an oblique injury, Gordon Wittenmyer of The Cincinnati Enquirer reports.

Manager Terry Francona said that it is a mild oblique injury and that Ferguson will be out "a couple of weeks" and that "he has to heal the way it heals," per Charlie Goldsmith of Fox 19 Now Cincinnati. The southpaw was signed by the Reds in December and is likely to fill a middle-relief role when healthy.

Manaea gave up three runs on six hits with four strikeouts and one walk over 2.2 innings during Thursday's Grapefruit League game against the Cardinals. According to Max Goodman of NJ.com, the left-hander averaged 89 mph with his fastball but said he isn't concerned by the lower velocity.

Manaea averaged 91.9 mph with his fastball last season, but he was limited to 15 appearances due to elbow issues and struggled to a 5.64 ERA. Pitchers will often experience a lower velocity during spring training while building up, so it's not necessarily a major concern. However, seeing Manaea's fastball regain some zip before Opening Day would go a long toward reassuring fantasy GMs thinking about using a late-round pick on the veteran southpaw.

Kerkering (hamstring) will throw a live batting practice session Saturday, Scott Lauber of The Philadelphia Inquirer reports.

The right-handed reliever has been slowed since the start of camp by a Grade 1 right hamstring strain, and this will be the second time he's faced hitters since the injury. If things go off without a hitch Saturday, Kerkering's Grapefruit League debut should be around the corner. Phillies manager Rob Thomson said Thursday that Kerkering will "possibly" have enough time to be ready for Opening Day.

The Cubs optioned Little to Triple-A Iowa on Thursday.

Little was unable to find his footing during spring training with four earned runs allowed over 4.2 frames, so he won't make Chicago's Opening Day bullpen. The 25-year-old made just two big-league appearances last season but had a 3.46 ERA across 26 innings with the Cubs in 2024.

The Cubs optioned Rolison to Triple-A Iowa on Thursday.

The left-hander was claimed off waivers by the Cubs in January, but he'll be cut from big-league camp after giving up seven runs over 4.1 innings during spring training. Rolison made his MLB debut with 31 appearances for Colorado last year and finished with a 7.02 ERA. 1.77 WHIP and 25:20 K:BB across 42.1 innings.

Beeter struck out three batters and walked one during his lone inning of work in Tuesday's Grapefruit League win over the Marlins.

After being traded from the Bronx to Washington last season, Beeter turned in a 2.49 ERA and 1.02 WHIP to go with a 32:14 K:BB over 21.2 innings. He's followed up his impressive start with the Nats by allowing two runs (both unearned) across three frames in spring training, collecting five strikeouts in the process. The Nationals entered spring camp without a clear go-to choice for ninth-inning work, but the 27-year-old righty seems like a strong contender to open the season as the team's preferred closer based on his recent performance.

Atlanta reassigned Karinchak to minor-league camp Wednesday.

Karinchak did all he could to earn a spot as a non-roster invitee, striking out nine while yielding just one hit and two walks over four scoreless spring frames, but it wasn't enough. The 30-year-old hasn't seen action at the big-league level since 2023, but he could get a chance with Atlanta this season if he gets off to a good start at Triple-A Gwinnett.