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Pearson allowed four hits and a single run, fanning eight, over 3.2 innings is his season debut at Triple-A Buffalo on Tuesday.

Pearson walked just one batter, throwing 53 of his 78 pitches for strikes, and will likely be looking to build up his pitch count in his next appearance. He could be a candidate for a rotation spot with the Blue Jays after a few more starts in Buffalo.

De Leon was optioned to Triple-A Louisville on Wednesday.

De Leon had allowed at least two runs in each of his last three relief outings, and he has an 8.35 ERA and 1.80 ERA in 18.1 innings to begin the season. The right-hander lost out on his rotation spot in early April when Sonny Gray returned to action, and he's now off the big-league roster altogether for the time being. De Leon will attempt to sort things out in the minors after left-hander Cionel Perez was recalled Wednesday.

Perez was recalled by the Reds on Wednesday.

Perez made 10 relief appearances for Cincinnati to begin the year and posted an 8.31 ERA and 1.62 WHIP in 8.2 innings. The southpaw pitched in Tuesday's season opener for Triple-A Louisville and allowed no hits and a walk while striking out two in one scoreless inning. He'll now return to the major-league bullpen after right-hander Jose De Leon was sent down in a corresponding move.

Kittredge will work as the Rays' opening pitcher in front of bulk reliever Ryan Yarbrough in Wednesday's game against the Angels, Adam Berry of MLB.com reports.

Kittredge hasn't surpassed two innings or 26 pitches in any of his nine outings this season, so he shouldn't be expected to push far past those levels before giving way to Yarbrough. The 31-year-old right-hander has posted a 1.54 ERA and 0.77 WHIP across 11.2 innings in 2021.

Yarbrough will work as the Rays' primary pitcher behind opener Andrew Kittredge in Wednesday's game against the Angels, Adam Berry of MLB.com reports.

Yarbrough has operated as a traditional starter in four of his first six starts, but he'll be following an opener for the third time in his last four turns through the rotation. He's enjoyed far better results in his two outings as a primary pitcher, limiting opposing batters to a .411 OPS while going 1-0 with 10 strikeouts across 10.2 innings.

Ginkel (0-1) took the loss Tuesday, allowing three runs on three hits while striking out one over a third of an inning in a 9-3 loss to Miami.

The Diamondbacks had just clawed their way back to tie the game in the top of the eighth, but it took just two batters in the bottom half of the inning for Miami to reclaim the lead off the usually reliable Ginkel. Throw in some shoddy defense and the Marlins pushed six runs across the plate. Ginkel entered the game with a 3.27 ERA and 1.27 WHIP before picking up his first loss of the season.

Kay (0-2) allowed four runs on four hits and two walks while striking out four over four innings to take the loss against Oakland on Tuesday.

The left-hander's second appearance of the season went much like his first, as Kay was unable to pitch beyond the fourth inning and allowed four earned runs. All of the damage against him came in the second frame, when Oakland struck for a two-run double and a two-run home run. Kay has now allowed eight earned runs over 7.1 innings this season while compiling a 7:2 K:BB. He could get another start this weekend at Houston, but Kay will likely eventually cede his rotation spot to Nate Pearson (groin).

Wittgren (1-1) pitched a perfect seventh inning to earn the win in Tuesday's 7-3 victory over Kansas City.

Wittgren became the pitcher of record when Cleveland rallied for four runs in the top of the eighth inning. The right-hander has kept runs off the scoreboard in five of his last six outings. He's had a rough start to the year with a 6.48 ERA, 1.44 WHIP and 7:4 K:BB across 8.1 innings, but he's been more effective in recent outings. He's picked up one save and three holds in nine appearances, although Wittgren seems to do better in a lower-leverage role.

Hentges gave up two runs on six hits and two walks with a pair of strikeouts in 3.1 innings in Tuesday's 7-3 win over Kansas City. He did not factor in the decision.

Hentges was a little too generous with baserunners, although he largely got away with it. Salvador Perez got the better of the southpaw twice, hitting an RBI single in the third inning and a solo home run in the fifth. Hentges has a 5.00 ERA, 1.78 WHIP and 8:2 K:BB across nine innings this season. He has a loose grip on the fifth starter role and tentatively lines up to face Cincinnati at home this weekend if he remains in the rotation.

Maton allowed a run on two hits and a walk with three strikeouts in Tuesday's 7-3 win over Kansas City. He did not factor in the decision.

Maton worked as an opener Tuesday, and the only run he allowed came on a Michael Taylor single in the second inning. Through 10 innings this season, Maton owns a 4.50 ERA, 1.30 WHIP and 13:5 K:BB. He'll likely return to a low-leverage role in the bullpen.