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Week 4 of the NFL season brings plenty of tough questions for owners as they set their Fantasy football lineups. Should you go with a more proven option like 49ers quarterback Brock Purdy, who faces a tough New England Patriots defense, or roll the dice on a lower-owned, high-upside option like Panthers quarterback Andy Dalton, who threw for 319 yards and three touchdowns in last week's win over the Raiders? Is a player like Ravens tight end Mark Andrews, who didn't record a single catch last week, safe to rely on in Week 4 Fantasy football lineups?

These are the types of questions Fantasy football 2024 owners will have to answer before locking in their Week 4 Fantasy football picks. Owners around the country know a victory this early in the season could be the determining factor between their team making the playoffs or going home emptyhanded. Therefore, before you lock in your lineups, be sure to check out the Week 4 Fantasy football rankings from the proven computer model at SportsLine.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons, especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

The same model has a proven track record of providing Fantasy football tips, including being ahead of the curve on players like A.J. Brown, Jonathan Taylor, Derrick Henry, Christian McCaffrey, Alvin Kamara, and Jahmyr Gibbs. Anybody who banked on players like those made a run at their league title.

Now, SportsLine has simulated the entire Week 4 NFL schedule 10,000 times and released its latest Week 4 Fantasy football rankings. Head to SportsLine now to see them

Top Week 4 Fantasy football QB rankings

Here's a look at SportsLine's top Week 4 Fantasy football QB picks: 

1. Kyler Murray, Arizona Cardinals: Murray completed 21 of 34 passes for 207 yards with a touchdown and an interception in Arizona's loss against Detroit. He also added five rushes for 45 yards, which led the team. Murray has a mouthwatering matchup against the Commanders on Sunday, a defense that's giving up 377.3 yards per game on average. 

2. Jayden Daniels, Washington Commanders: Daniels had a breakout performance in Monday's victory over the Bengals. Daniels completed 21 of 23 pass attempts for 254 yards, setting an NFL rookie record for completion percentage at 91.3%. He threw two touchdown passes and also added a rushing score, showcasing his ability as a dual-threat QB. 

3. Joe Burrow, Cincinnati Bengals: Burrow completed 29 of 38 pass attempts for 324 yards and three touchdowns in Monday's loss to the Commanders. The former LSU standout put together his best Fantasy performance through three weeks, missing just nine passes in a high-scoring affair. Burrow will need to be at his best for the Bengals to secure their first victory of the season on Sunday. See more top QBs here.

Top Week 4 Fantasy football RB rankings

Here's a look at SportsLine's top Week 4 Fantasy football RB picks: 

1. De'Von Achane, Miami Dolphins: The Dolphins struggled mightily on offense last week, scoring only three points in a lopsided loss against the Seahawks. This week, Achane and the Dolphins square off against the Tennessee Titans on Monday, a defense that gave up 188 rushing yards last week. 

2. Breece Hall, New York Jets: Hall rushed 16 times for 54 yards and a touchdown and secured four of five targets for 29 yards in the Jets' 24-3 win over the Patriots last Thursday. Hall now has 16 catches on 19 targets through the first three games, providing Fantasy owners with tremendous upside ahead of a favorable Week 4 home matchup against the Broncos.

3. Saquon Barkley, Philadelphia Eagles: Barkley has been sensational for the Eagles in his first season in Philadelphia. He leads the NFL with 351 rushing yards and four rushing scores and has finished with 95 or more rushing yards in each of his first three games. See more top RBs here.

Top Week 4 Fantasy football WR rankings

Here's a look at SportsLine's top Week 4 Fantasy football WR picks: 

1. Nico Collins, Houston Texans: Collins has been extremely effective for the Texans through the first three weeks of the season. He leads the NFL with 338 receiving yards and averages a whopping 18.8 yards per reception. In last week's loss against the Vikings, Collins was targeted 10 times, securing four catches for 86 yards.

2. CeeDee Lamb, Dallas Cowboys: Lamb has finished with five or fewer receptions in each of his first three games this season. However, Lamb has a great chance to bounce back on Thursday when the Cowboys take on the Giants in an NFC East showdown. In his last meeting with New York, Lamb hauled in 11 receptions for 151 yards and two total touchdowns.

3. Marvin Harrison Jr., Arizona Cardinals: Harrison is having a stellar rookie season in Arizona. He's coming off another strong showing in Arizona's loss to the Lions, logging five catches for 64 yards and a touchdown. The rookie has now scored three touchdowns in his last two games and he'll look to continue his hot start against the Commanders on Sunday. See more top WRs here.

Top Week 4 Fantasy football TE rankings

Here's a look at SportsLine's top Week 4 Fantasy football TE picks:

1. Trey McBride, Arizona Cardinals: McBride has yet to find the end zone, but he remains one of Kyler Murray's favorite targets. He had a 28.8% target share through two weeks and will now get a favorable matchup against the Commanders on Sunday. 

2. Dallas Goedert, Philadelphia Eagles: Goedert was extremely effective in Philadelphia's victory over the Saints on Sunday, bringing in 10 of 11 targets for 170 yards. Both Goedert's reception and receiving yardage totals were career highs, and he could be in line for another busy outing when the Eagles take on the Tampa Bay Buccaneers on Sunday. 

3. Travis Kelce, Kansas City Chiefs: Kansas City's star tight end has a meager 69 receiving yards and has yet to score a touchdown heading into a Week 4 road game against the Chargers. However, Kelce remains a scoring threat in the red zone and one of Patrick Mahomes' favorite targets in the passing game. See more top TEs here.

Top Week 4 Fantasy football defense rankings 

Here's a look at SportsLine's top three Week 4 Fantasy football D/ST picks:

1. Jets D/ST: The Jets are extremely stingy against the pass, ranking fourth in the NFL in passing yards allowed per game (150.7). The Jets held the Patriots to just three points in their only home game this season and on Sunday, New York hosts the Denver Broncos, an offense that has six turnovers this season. 

2. Packers D/ST: Green Bay's defense dominated in last week's victory over the Titans, recording eight sacks and two interceptions. 

3. Dolphins D/ST: The Dolphins are giving up 294.7 yards per game this season, which ranks 11th in the NFL. Miami will now face a Titans team that leads the NFL with eight turnovers on offense. Tennessee also gave up eight sacks last week against the Packers. See more top D/ST here

How to get Week 4 Fantasy football rankings

Now that you know who the top three at each position are, you'll want to see the full Week 4 Fantasy football rankings from SportsLine. The model has identified a stunner in the top 10 at running back, and knowing who it is can give you a huge edge in your league. Head to SportsLine now to get Week 4 Fantasy football rankings

So who should you target in your Week 4 Fantasy football rankings, and which surprising RB could lead you to victory? Visit SportsLine now to get Week 4 Fantasy Football rankings for every single position, all from the model that has a history of making league-winning calls, and find out.